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https://ah.lib.nccu.edu.tw/handle/140.119/65230
題名: | Metabotropic glutamate receptor 5 modulates behavioral and hypothermic responses to toluene in rats | 作者: | Chan, Ming-Huan ; Lee, Chia-Chi ; Lin, Bih-Fen ; Wu, Chia-Yen ; Chen, Hwei-Hsien 詹銘煥 |
貢獻者: | 神科所 | 關鍵詞: | Toluene; mGluR5; NMDA receptor; Motor coordination; Learning; Hypothermia | 日期: | 2012 | 上傳時間: | 9-Apr-2014 | 摘要: | Toluene, a widely used and commonly abused organic solvent, produces various behavioral disturbances in both humans and animals. Blockade of N-methyl-d-aspartate (NMDA) receptors has been suggested to play a critical role in acute toluene-induced behavioral manifestations. Activation of type 5 metabotropic glutamate receptors (mGluR5) attenuates behavioral responses induced by NMDA receptor blockade. The present study elucidated the role of mGluR5 on toluene-induced behavioral and hypothermic responses. Male Sprague–Dawley rats received the mGluR5 agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) or antagonist 6-methyl-2-[phenylethynyl]-pyridine (MPEP) prior to toluene administration. Rotarod test, step-down inhibitory avoidance learning task, and rectal temperature were monitored. Pretreatment of CHPG and MPEP attenuated and potentiated these toluene-induced responses, respectively. In addition, the inhibitory effects of CHPG on toluene-induced motor incoordination, learning impairment, and hypothermia were reversed by the protein kinase C (PKC) inhibitor chelerythrine chloride. These findings suggest that mGluR5 may modulate the neural circuits responsible for motor incoordination, learning impairment, and hypothermic action of toluene through a PKC-dependent signal transduction pathway. | 關聯: | Pharmacology, biochemistry and behavior,103(2), 418-424 | 資料來源: | http://dx.doi.org/10.1016/j.pbb.2012.09.019 | 資料類型: | article |
Appears in Collections: | 期刊論文 |
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