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題名: | The group II metabotropic glutamate receptor agonist LY379268 reduces toluene-induced enhancement of brain-stimulation reward and behavioral disturbances | 作者: | Chan, Ming-Huan;Tsai, Yi-Ling;Lee, Mei-Yi;Stoker, Astrid;Markou, K. Athina;Chen, Hwei-Hsien 詹銘煥;蔡依玲 |
貢獻者: | 神經科學研究所;心腦學研究中心 | 關鍵詞: | Toluene;mGluR2/3;Motor coordination;Object recognition;Social interaction;Intracranial self-stimulation | 日期: | Jun-2015 | 上傳時間: | 5-Aug-2015 | 摘要: | Rationale Toluene, a widely abused solvent with demonstrated addictive potential in humans, hasbeen reported to negatively modulate N-methyl-D-aspartate receptors (NMDARs) and alter glutamatergicneurotransmission. The group II metabotropic glutamate receptor (mGluR) agonist LY379268 has beenshown to regulate glutamate release transmission and NMDAR function and block toluene-induced locomotorhyperactivity. However, remaining unknown is whether group II mGluRs are involved in the toluene-induced reward-facilitating effect and other behavioral manifestations. Objectives The present study evaluated the effects of LY379268 on toluene-induced reward enhancement, motor incoordination, recognition memory impairment, and social interaction deficits. Results Our data demonstrated that LY379268 significantly reversed the toluene-induced lowering of intracranial selfstimulation (ICSS) thresholds and impairments in novel objectrecognition, rotarod performance, and social interaction with different potencies. Conclusions These results indicate a negative modulatory role of group II mGluRs in acute toluene-induced reward-facilitating and behavioral effects and suggest that group II mGluR agonists may have therapeutic potential for toluene addiction and the prevention of toluene intoxication caused by occupational or intentional exposure. | 關聯: | Psychopharmacology | 資料類型: | article | DOI: | http://dx.doi.org/10.1007/s00213-015-3973-3 |
Appears in Collections: | 期刊論文 |
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