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題名: | Betaine enhances antidepressant-like, but blocks psychotomimetic effects of ketamine in mice | 作者: | 詹銘煥 Lin, Jen-Cheng;Lee, Mei-Yi;Chan, Ming-Huan;Chen, Yi-Chyan;Chen, Hwei-Hsien |
貢獻者: | 神科所 | 關鍵詞: | Behavior ; NMDA receptor ; Depression ; Schizophrenia ; Prepulse inhibition | 日期: | Sep-2016 | 上傳時間: | 5-Jun-2017 | 摘要: | Ketamine is emerging as a new hope against depression, but ketamine-associated psychotomimetic effects limit its clinical use. An adjunct therapy along with ketamine to alleviate its adverse effects and even potentiate the antidepressant effects might be an alternative strategy. Betaine, a methyl derivative of glycine and a dietary supplement, has been shown to have antidepressant-like effects and to act like a partial agonist at the glycine site of N-methyl-D-aspartate receptors (NMDARs). Accordingly, betaine might have potential to be an adjunct to ketamine treatment for depression. The antidepressant-like effects of ketamine and betaine were evaluated by forced swimming test and novelty suppressed feeding test in mice. Both betaine and ketamine produced antidepressant-like effects. Furthermore, we determined the effects of betaine on ketamine-induced antidepressant-like and psychotomimetic behaviors, motor incoordination, hyperlocomotor activity, and anesthesia. The antidepressant-like responses to betaine combined with ketamine were stronger than their individual effects. In contrast, ketamine-induced impairments in prepulse inhibition, novel object recognition test, social interaction, and rotarod test were remarkably attenuated, whereas ketamine-induced hyperlocomotion and loss of righting reflex were not affected by betaine. These findings revealed that betaine could enhance the antidepressant-like effects, yet block the psychotomimetic effects of ketamine, suggesting that betaine can be considered as an add-on therapy to ketamine for treatment-resistant depression and suitable for the treatment of depressive symptoms in patients with schizophrenia. | 關聯: | Psychopharmacology, Vol.233, Issue 17, pp.3223-35 | 資料類型: | article | DOI: | http://dx.doi.org/10.1007/s00213-016-4359-x |
Appears in Collections: | 期刊論文 |
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