Please use this identifier to cite or link to this item:
https://ah.lib.nccu.edu.tw/handle/140.119/111259
題名: | Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants | 作者: | Lin, Chih-Lin;Kao, Jia-Horng 林志陵 |
貢獻者: | 心理系 | 日期: | 2017 | 上傳時間: | 20-Jul-2017 | 摘要: | Molecular epidemiologic studies reveal remarkable differences in the geographical distribution of hepatitis B virus (HBV) genotypes. The frequency of mutants among HBV genotypes also varies. The role of HBV genotypes/mutants in the pathogenesis of HBV infection and natural history of HBV infection has been extensively investigated. The distribution of HBV genotypes in acute hepatitis B patients reflects the predominant genotypes in a given geographic area. In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B. HBV genotypes C, D and F carry a higher lifetime risk of cirrhosis and HCC development than genotype A and B. HBV pre-S/S gene mutations were associated with immune escape of hepatitis B immunoglobulin or vaccine-induced immunity. Mutations in the pre-S, core promoter and X regions correlate with an increased risk of cirrhosis and HCC. In summary, HBV genotypes and mutants are associated with the disease progression and long-term outcome of HBV infection. They may serve as viral genetic markers for risk stratification of chronic hepatitis B patients in clinical practice. © 2017 Elsevier Ltd. | 關聯: | Best Practice and Research: Clinical Gastroenterology, Available online 5 May 2017 | 資料類型: | article | DOI: | http://dx.doi.org/10.1016/j.bpg.2017.04.010 |
Appears in Collections: | 期刊論文 |
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.