Please use this identifier to cite or link to this item:
https://ah.lib.nccu.edu.tw/handle/140.119/111259
DC Field | Value | Language |
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dc.contributor | 心理系 | |
dc.creator | Lin, Chih-Lin;Kao, Jia-Horng | en-US |
dc.creator | 林志陵 | zh-tw |
dc.date | 2017 | |
dc.date.accessioned | 2017-07-20T07:20:28Z | - |
dc.date.available | 2017-07-20T07:20:28Z | - |
dc.date.issued | 2017-07-20T07:20:28Z | - |
dc.identifier.uri | http://nccur.lib.nccu.edu.tw/handle/140.119/111259 | - |
dc.description.abstract | Molecular epidemiologic studies reveal remarkable differences in the geographical distribution of hepatitis B virus (HBV) genotypes. The frequency of mutants among HBV genotypes also varies. The role of HBV genotypes/mutants in the pathogenesis of HBV infection and natural history of HBV infection has been extensively investigated. The distribution of HBV genotypes in acute hepatitis B patients reflects the predominant genotypes in a given geographic area. In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B. HBV genotypes C, D and F carry a higher lifetime risk of cirrhosis and HCC development than genotype A and B. HBV pre-S/S gene mutations were associated with immune escape of hepatitis B immunoglobulin or vaccine-induced immunity. Mutations in the pre-S, core promoter and X regions correlate with an increased risk of cirrhosis and HCC. In summary, HBV genotypes and mutants are associated with the disease progression and long-term outcome of HBV infection. They may serve as viral genetic markers for risk stratification of chronic hepatitis B patients in clinical practice. © 2017 Elsevier Ltd. | |
dc.format.extent | 590362 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.relation | Best Practice and Research: Clinical Gastroenterology, Available online 5 May 2017 | |
dc.title | Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants | en-US |
dc.type | article | |
dc.identifier.doi | 10.1016/j.bpg.2017.04.010 | |
dc.doi.uri | http://dx.doi.org/10.1016/j.bpg.2017.04.010 | |
item.openairetype | article | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | restricted | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | 期刊論文 |
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