Please use this identifier to cite or link to this item:
https://ah.lib.nccu.edu.tw/handle/140.119/115565
DC Field | Value | Language |
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dc.contributor | 心理學系 | zh_TW |
dc.creator | 藍亭 | zh_TW |
dc.creator | Martino, Matteo | en_US |
dc.creator | Magioncalda, Paola | en_US |
dc.creator | Yu, Hua | en_US |
dc.creator | Li, Xiaojing | en_US |
dc.creator | Wang, Qiang | en_US |
dc.creator | Meng, Yajing | en_US |
dc.creator | Deng, Wei | en_US |
dc.creator | Li, Yinfei | en_US |
dc.creator | Li, Mingli | en_US |
dc.creator | Ma, Xiaohong | en_US |
dc.creator | Lane, Timothy | en_US |
dc.creator | Duncan, Niall W. | en_US |
dc.creator | Northoff, Georg | en_US |
dc.creator | Li, Tao | en_US |
dc.date | 2018-02 | - |
dc.date.accessioned | 2018-01-15T03:39:34Z | - |
dc.date.available | 2018-01-15T03:39:34Z | - |
dc.date.issued | 2018-01-15T03:39:34Z | - |
dc.identifier.uri | http://nccur.lib.nccu.edu.tw/handle/140.119/115565 | - |
dc.description.abstract | Objective: The dopamine hypothesis is one of the most influential theories of the neurobiological background of schizophrenia (SCZ). However, direct evidence for abnormal dopamine-related subcortical-cortical circuitry disconnectivity is still lacking. The aim of this study was therefore to test dopamine-related substantia nigra (SN)-based striato-thalamo-cortical resting-state functional connectivity (FC) in SCZ. Method: Based on our a priori hypothesis, we analyzed a large sample resting-state functional magnetic resonance imaging (fMRI) dataset from first-episode drug-naïve SCZ patients (n = 112) and healthy controls (n = 82) using the SN as the seed region for an investigation of striato-thalamo-cortical FC. This was done in the standard band of slow frequency oscillations and then in its subfrequency bands (Slow4 and Slow5). Results: The analysis showed in SCZ: (1) reciprocal functional hypo-connectivity between SN and striatum, with differential patterns for Slow5 and Slow4; (2) functional hypo-connectivity between striatum and thalamus, as well as functional hyper-connectivity between thalamus and sensorimotor cortical areas, specifically in Slow4; (3) correlation of thalamo-sensorimotor functional hyper-connectivity with psychopathological symptoms. Conclusions: We demonstrate abnormal dopamine-related SN-based striato-thalamo-cortical FC in slow frequency oscillations in first-episode drug-naive SCZ. This suggests that altered dopaminergic function in the SN leads to abnormal neuronal synchronization (as indexed by FC) within subcortical-cortical circuitry, complementing the dopamine hypothesis in SCZ on the regional level of resting-state activity. | en_US |
dc.format.extent | 103 bytes | - |
dc.format.mimetype | text/html | - |
dc.relation | Schizophrenia Bulletin, Volume 44, Issue 2, Pages 419–431 | en_US |
dc.subject | schizophrenia:substantia nigra:resting-state, fMRI:functional connectivity:slow frequency bands:neural synchronization | en_US |
dc.title | Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia. | en_US |
dc.type | article | - |
dc.identifier.doi | 10.1093/schbul/sbx067 | - |
dc.doi.uri | http://dx.doi.org/10.1093/schbul/sbx067 | - |
item.grantfulltext | restricted | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | 期刊論文 |
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