Please use this identifier to cite or link to this item:
https://ah.lib.nccu.edu.tw/handle/140.119/120101
DC Field | Value | Language |
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dc.contributor | 神科所 | |
dc.creator | Lin, Yi-Ruu;Peng, Kou-Cheng;Chan, Ming-Huan;Peng, Huan-Lin;Liu, Shu-Ying | en_US |
dc.creator | 詹銘煥 | zh_TW |
dc.creator | Chan, Ming-Huan | en_US |
dc.date | 2017-12 | |
dc.date.accessioned | 2018-09-17T10:03:18Z | - |
dc.date.available | 2018-09-17T10:03:18Z | - |
dc.date.issued | 2018-09-17T10:03:18Z | - |
dc.identifier.uri | http://nccur.lib.nccu.edu.tw/handle/140.119/120101 | - |
dc.description.abstract | To document the safety of pachybasin, a secondary metabolite of Trichoderma harzianum, for use as a bioagricultural agent, it was subjected to general toxicological testing in mice and developmental toxicity in zebrafish. With either 5 or 20 mg kg-1 pachybasin i.p. injection, mice behavioral responses such as motor coordination, spontaneous locomotor activity, or nociceptive pain were not influenced. In long-term effect (daily injection for 14 days), the physiological, hematological, liver, and kidney functions were not altered either. Evidence for the developmental toxicity of pachybasin (10-100 μM) in 72-h exposure period was shown in zebrafish larvae, based on developmental retardation, impairment of chorion, and increase of mortality. In summary, there are no significant general toxicities presented in the pachybasin-treated adult male mice. However, the embryo-toxicity in aquatic biota should be taken into consideration during bioagricultural agent application. | en_US |
dc.format.extent | 108 bytes | - |
dc.format.mimetype | text/html | - |
dc.relation | J. Agric. Food Chem. 65, 48, 10489-10494 | |
dc.relation | PMID: 29111710 | |
dc.subject | Trichoderma harzianum; developmental toxicity; general toxicity; pachybasin | en_US |
dc.title | Effect of Pachybasin on General Toxicity and Developmental Toxicity in Vivo | en_US |
dc.type | article | |
dc.identifier.doi | 10.1021/acs.jafc.7b03879 | |
dc.doi.uri | https://doi.org/10.1021/acs.jafc.7b03879 | |
item.fulltext | With Fulltext | - |
item.grantfulltext | restricted | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | 期刊論文 |
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