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https://ah.lib.nccu.edu.tw/handle/140.119/120974
題名: | Mullerian Inhibiting Substance contributes to sex-linked biases in the brain and behavior | 作者: | Wang, Pei-Yu;Protheroe, Anna;Clarkson, Andrew N.;Imhoff, Floriane;Koishi, Kyoko;McLennan, Ian S. 王培育 Wang, Pei-Yu |
貢獻者: | 神科所 | 關鍵詞: | anti-Müllerian hormone; exploratory behavior; motor neuron; sexual dimorphism | 日期: | Apr-2009 | 上傳時間: | 21-Nov-2018 | 摘要: | Many behavioral traits and most brain disorders are common to males and females but are more evident in one sex than the other. The control of these subtle sex-linked biases is largely unstudied and has been presumed to mirror that of the highly dimorphic reproductive nuclei. Sexual dimorphism in the reproductive tract is a product of Müllerian inhibiting substance (MIS), as well as the sex steroids. Males with a genetic deficiency in MIS signaling are sexually males, leading to the presumption that MIS is not a neural regulator. We challenge this presumption by reporting that most immature neurons in mice express the MIS-specific receptor (MISRII) and that male Mis−/− and Misrii−/− mice exhibit subtle feminization of their spinal motor neurons and of their exploratory behavior. Consequently, MIS may be a broad regulator of the subtle sex-linked biases in the nervous system. | 關聯: | Proceedings of the National Academy of Sciences of the United States of America, Vol.106, No.17, pp.7203-7208 PMID: 19359476 |
資料類型: | article | DOI: | https://doi.org/10.1073/pnas.0902253106 |
Appears in Collections: | 期刊論文 |
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