Please use this identifier to cite or link to this item:
https://ah.lib.nccu.edu.tw/handle/140.119/120974
DC Field | Value | Language |
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dc.contributor | 神科所 | |
dc.creator | Wang, Pei-Yu;Protheroe, Anna;Clarkson, Andrew N.;Imhoff, Floriane;Koishi, Kyoko;McLennan, Ian S. | |
dc.creator | 王培育 | |
dc.creator | Wang, Pei-Yu | |
dc.date | 2009-04 | |
dc.date.accessioned | 2018-11-21T08:24:01Z | - |
dc.date.available | 2018-11-21T08:24:01Z | - |
dc.date.issued | 2018-11-21T08:24:01Z | - |
dc.identifier.uri | http://nccur.lib.nccu.edu.tw/handle/140.119/120974 | - |
dc.description.abstract | Many behavioral traits and most brain disorders are common to males and females but are more evident in one sex than the other. The control of these subtle sex-linked biases is largely unstudied and has been presumed to mirror that of the highly dimorphic reproductive nuclei. Sexual dimorphism in the reproductive tract is a product of Müllerian inhibiting substance (MIS), as well as the sex steroids. Males with a genetic deficiency in MIS signaling are sexually males, leading to the presumption that MIS is not a neural regulator. We challenge this presumption by reporting that most immature neurons in mice express the MIS-specific receptor (MISRII) and that male Mis−/− and Misrii−/− mice exhibit subtle feminization of their spinal motor neurons and of their exploratory behavior. Consequently, MIS may be a broad regulator of the subtle sex-linked biases in the nervous system. | en_US |
dc.format.extent | 757283 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.relation | Proceedings of the National Academy of Sciences of the United States of America, Vol.106, No.17, pp.7203-7208 | |
dc.relation | PMID: 19359476 | |
dc.subject | anti-Müllerian hormone; exploratory behavior; motor neuron; sexual dimorphism | en_US |
dc.title | Mullerian Inhibiting Substance contributes to sex-linked biases in the brain and behavior | en_US |
dc.type | article | |
dc.identifier.doi | 10.1073/pnas.0902253106 | |
dc.doi.uri | https://doi.org/10.1073/pnas.0902253106 | |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | restricted | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | 期刊論文 |
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File | Description | Size | Format | |
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zpq7203.pdf | 739.53 kB | Adobe PDF2 | View/Open |
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