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題名: | Serotonin receptor HTR6 mediates dietary restriction-induced memory enhancement | 作者: | 廖瑞銘 Liao, Ruey-Ming Teng, Ling-Ling Lu, Guan-Ling Chiou, Lih-Chu Lin, Wei-Sheng |
貢獻者: | 心理系 | 日期: | Apr-2019 | 上傳時間: | 21-Nov-2019 | 摘要: | Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan—a precursor amino acid for serotonin biosynthesis in the brain—and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced longterm potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake. | 關聯: | PLOS Biology, Vol.17, No.3, pp.e2007097 | 資料類型: | article | DOI: | https://doi.org/10.1371/journal.pbio.2007097 |
Appears in Collections: | 期刊論文 |
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