Please use this identifier to cite or link to this item:
https://ah.lib.nccu.edu.tw/handle/140.119/127386
DC Field | Value | Language |
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dc.contributor | 心理系 | - |
dc.creator | 廖瑞銘 | - |
dc.creator | Liao, Ruey-Ming | - |
dc.creator | Teng, Ling-Ling | - |
dc.creator | Lu, Guan-Ling | - |
dc.creator | Chiou, Lih-Chu | - |
dc.creator | Lin, Wei-Sheng | - |
dc.date | 2019-04 | - |
dc.date.accessioned | 2019-11-21T02:40:57Z | - |
dc.date.available | 2019-11-21T02:40:57Z | - |
dc.date.issued | 2019-11-21T02:40:57Z | - |
dc.identifier.uri | http://nccur.lib.nccu.edu.tw/handle/140.119/127386 | - |
dc.description.abstract | Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan—a precursor amino acid for serotonin biosynthesis in the brain—and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced longterm potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake. | - |
dc.format.extent | 3528055 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.relation | PLOS Biology, Vol.17, No.3, pp.e2007097 | - |
dc.title | Serotonin receptor HTR6 mediates dietary restriction-induced memory enhancement | - |
dc.type | article | - |
dc.identifier.doi | 10.1371/journal.pbio.2007097 | - |
dc.doi.uri | https://doi.org/10.1371/journal.pbio.2007097 | - |
item.grantfulltext | restricted | - |
item.openairetype | article | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | 期刊論文 |
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