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https://ah.lib.nccu.edu.tw/handle/140.119/128685
題名: | Contribution of caspase-8 genotypes to colorectal cancer risk in Taiwan | 作者: | 趙知章 Chao, Chih-Chang MH, Wu CW, Tsai DT*, Bau YW, Hung CL, Gong TC, Yueh SC, Wang YL, Lai SW, Hsu WS, Chang |
貢獻者: | 神科所 | 關鍵詞: | Case–control study; Taiwan; caspase-8; colorectal cancer; genotype; polymorphism | 日期: | Jun-2019 | 上傳時間: | 20-Feb-2020 | 摘要: | BACKGROUND/AIM:The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls.MATERIALS AND METHODS:The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined.RESULTS:The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status.CONCLUSION:Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis. | 關聯: | Anticancer Research, Vol.39, No.6, pp.2791-2797 | 資料類型: | article | DOI: | https://doi.org/10.21873/anticanres.13406 |
Appears in Collections: | 期刊論文 |
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