Please use this identifier to cite or link to this item:
https://ah.lib.nccu.edu.tw/handle/140.119/128685
DC Field | Value | Language |
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dc.contributor | 神科所 | |
dc.creator | 趙知章 | |
dc.creator | Chao, Chih-Chang | |
dc.creator | MH, Wu | |
dc.creator | CW, Tsai | |
dc.creator | DT*, Bau | |
dc.creator | YW, Hung | |
dc.creator | CL, Gong | |
dc.creator | TC, Yueh | |
dc.creator | SC, Wang | |
dc.creator | YL, Lai | |
dc.creator | SW, Hsu | |
dc.creator | WS, Chang | |
dc.date | 2019-06 | |
dc.date.accessioned | 2020-02-20T03:56:01Z | - |
dc.date.available | 2020-02-20T03:56:01Z | - |
dc.date.issued | 2020-02-20T03:56:01Z | - |
dc.identifier.uri | http://nccur.lib.nccu.edu.tw/handle/140.119/128685 | - |
dc.description.abstract | BACKGROUND/AIM:The aim of this study was to examine the role of caspase-8 rs3834129 polymorphism on colorectal cancer (CRC) risk in Taiwanese CRC patients and healthy controls.MATERIALS AND METHODS:The caspase-8 rs3834129 (-652 6N insertion/deletion) polymorphic genotypes were analyzed in 362 patients with CRC and the same number of age- and gender-matched healthy subjects. The interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinicopathological features were also examined.RESULTS:The percentage of variants ID and DD for caspase-8 rs3834129 genotype were 37.6 and 5.8% in CRC group and 39.0 and 6.6% in the control group, respectively (p for trend=0.7987). The allelic frequency distribution analysis showed that caspase-8 rs3834129 D allele conferred a non-significant lower susceptibility for CRC compared with I allele (OR=0.92, 95%CI=0.74-1.20, p=0.5063). There was no obvious link between caspase-8 rs3834129 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No statistically significant correlation was observed between caspase-8 rs3834129 genotypic distribution and age, gender, tumor size, location or metastasis status.CONCLUSION:Overall, caspase-8 rs3834129 genotypes may not serve as predictors for CRC risk or prognosis. | |
dc.format.extent | 108 bytes | - |
dc.format.mimetype | text/html | - |
dc.relation | Anticancer Research, Vol.39, No.6, pp.2791-2797 | |
dc.subject | Case–control study; Taiwan; caspase-8; colorectal cancer; genotype; polymorphism | |
dc.title | Contribution of caspase-8 genotypes to colorectal cancer risk in Taiwan | |
dc.type | article | |
dc.identifier.doi | 10.21873/anticanres.13406 | |
dc.doi.uri | https://doi.org/10.21873/anticanres.13406 | |
item.fulltext | With Fulltext | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | restricted | - |
Appears in Collections: | 期刊論文 |
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