政大學術集成


Please use this identifier to cite or link to this item: https://ah.nccu.edu.tw/handle/140.119/137549


Title: Inositol hexaphosphate modulates the behavior of macrophages through alteration of gene expression involved in pathways of pro- and anti-inflammatory responses, and resolution of inflammation pathways
Authors: 陳紹寬
Chen, Shau-Kwaun
Wee, Yinshen
Yang, Chieh-Hsiang
Yen, Yu-Chun
Wang, Ching-Shuen
Contributors: 神科所
Date: 2021-06
Issue Date: 2021-10-27 10:56:50 (UTC+8)
Abstract: Inositol hexaphosphate (IP6) is a dietary compound commonly obtained from corn, rice, etc. Although we may consume significant amount of IP6 daily, it is unclear whether this diet will impact macrophages’ fate and function. Therefore, we characterized the underlying relationship between IP6 and macrophage polarization in this study. We specifically examined the signature gene expression profiles associated with pro- and anti-inflammatory responses, and resolution of inflammation pathways in macrophages under the influence of IP6. Interestingly, our data suggested that IP6 polarizes bone marrow-derived macrophages (BMDM) into an M2a-like subtype. Our results also demonstrated that IP6 reduces lipopolysaccharide-induced apoptosis and pro-inflammatory responses in macrophages. In contrast, the expression levels of genes related to anti-inflammatory responses and resolution of inflammation pathways are upregulated. Our findings collectively demonstrated that IP6 has profound modulation effects on macrophages, which warrant further research on the therapeutic benefits of IP6 for inflammatory diseases.
Relation: Food Science and Nutrition, 9:6, 3240-3249
Data Type: article
DOI link: https://doi.org/10.1002/fsn3.2286
Appears in Collections:[Graduate Institute of Neuroscience] Periodical Articles

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