Please use this identifier to cite or link to this item:
https://ah.lib.nccu.edu.tw/handle/140.119/30873
DC Field | Value | Language |
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dc.contributor.advisor | 薛慧敏 | zh_TW |
dc.contributor.author | 蘇慧玲 | zh_TW |
dc.creator | 蘇慧玲 | zh_TW |
dc.date | 2002 | en_US |
dc.date.accessioned | 2009-09-14 | - |
dc.date.available | 2009-09-14 | - |
dc.date.issued | 2009-09-14 | - |
dc.identifier | G0090354005 | en_US |
dc.identifier.uri | https://nccur.lib.nccu.edu.tw/handle/140.119/30873 | - |
dc.description | 碩士 | zh_TW |
dc.description | 國立政治大學 | zh_TW |
dc.description | 統計研究所 | zh_TW |
dc.description | 90354005 | zh_TW |
dc.description | 91 | zh_TW |
dc.description.abstract | 摘 要\r\n\r\n在基因微陣列(DNA microarrays)的技術中,可同時得到數以千筆的資料,為了找出具有顯著差異的基因,一般會考慮控制整體誤差率(familywise error rate,FWE) 的多重比較方法(multiple comparison procedures,MCP)。但當基因數或假設檢定個數過多時,其檢定會產生不易拒絕虛無假設的結果,使得結論過於保守。為解決此一問題,Benjamini & Hochberg(1995)建議採用控制錯誤發現率(false discovery rate,FDR)的方法來替代整體誤差率FWE。且Tusher et al.(2001)在DNA微陣列顯著分析(significance analysis of microarrays,SAM)的文章中提出利用排列分佈(permutations)估計錯誤發現率FDR的方法。本篇論文將介紹Tusher et al.(2001)所提出的SAM估計錯誤發現率FDR的方法,且提出一修正SAM方法:SAMM。另外介紹兩種控制顯著水準的統計方法:SAME和SAMT(t檢定)。透過電腦模擬驗證四種方法其錯誤發現率FDR的表現。 | zh_TW |
dc.description.abstract | Abstract\r\n\r\n\r\nDNA microarray technology provides tools enable to simultaneously study thousands of genes. A conservative multiple comparison procedure (MCP) controlling the familywise type I error rate (FWE) is considered. However, the conservativeness of a MCP becomes more and more severe as the number of comparisons (genes) increases. Instead of FWE, another error rate, the false discovery rate (FDR), is suggested. Tusher et al.(2001) proposed a statistical procedure, the Significance Analysis of Microarrays (SAM), to analyze a microarray data set. In which, the conclusion is drawn at a specific threshold and the false discovery rate (FDR) of the conclusion is estimated by permutations. In this paper, inspired by the SAM, three other methods are proposed. The performances of these methods are investigated and compared through simulations. | en_US |
dc.description.tableofcontents | 目 錄\r\n\r\n第一章 緒論 .....................................1\r\n第二章 SAM .....................................4\r\n第一節 固定門檻值(Δ)之統計方法..................4\r\n1.1 SAM .....................................4\r\n1.2 SAMM ....................................7\r\n第二節 固定顯著水準(α)之統計方法................8\r\n2.1 SAME .....................................8\r\n2.2 t檢定(SAMT)...............................8\r\n 第三節 錯誤發現率FDR之估計.......................8\r\n第三章 模擬.....................................9\r\n第一節 固定門檻值................................11\r\n第二節 固定顯著水準..............................16\r\n第四章 實例....................................21\r\n第五章 結論………………………………………………24\r\n\r\n參考文獻 ……………………………………………………25\r\n附錄:實例程式 | zh_TW |
dc.language.iso | en_US | - |
dc.source.uri | http://thesis.lib.nccu.edu.tw/record/#G0090354005 | en_US |
dc.subject | 整體誤差率 | zh_TW |
dc.subject | 多重比較方法 | zh_TW |
dc.subject | 錯誤發現率 | zh_TW |
dc.title | DNA微陣列基因顯著性分析驗證 | zh_TW |
dc.type | thesis | en |
dc.relation.reference | 參考文獻 | zh_TW |
dc.relation.reference | Benjamini, Y. & Hochberg, Y. (1995) “Controlling the false discovery rate: a practical and powerful approach to multiple testing”. J. R. Stat. Soc.Ser. B-Methodological, 57,289-300. | zh_TW |
dc.relation.reference | Efron, B. & Tibshirani, R. J. (1993) “An Introduction to the Bootstrap.” Chapman & Hall. | zh_TW |
dc.relation.reference | Kerr, M. K., Afshari, C. A., Bennett, L., Bushel, P., Martinez, J., Walker, N. J. and Churchill, G. A. (2001) “Statistical Analysis of a Gene Expression Microarray Experiment with Replication”. Statistica Sinica, 12, 203-218. | zh_TW |
dc.relation.reference | Kerr, M.K., Martin, M., and Churchill G.A. (2000). “Analysis of Variance for Gene Expres-sion Microarray Data.” Journal of Computational Biology, 7, 819-837. | zh_TW |
dc.relation.reference | Kikuchi, H., Hossain, A., Yoshida, H., and Kobayashi, S. (1998). “Induction of Cytochrome P-450 1A1 by Omeprazole in Human HepG2 Cells is Protein Tyrosine Kinase-Dependent and is Not Inhibited by Alpha-Naphtho avone.” Archives of Biochemical Biophysics , 358, 351-358. | zh_TW |
dc.relation.reference | Li, W., Harper, P.A., Tang, B.K., and Okey A.B. (1998). “Regulation of Cytochrome | zh_TW |
dc.relation.reference | P450 Enzymes by Aryl Hydrocarbon Receptor in Human Cells: CYP1A2 Expression | zh_TW |
dc.relation.reference | in the LS180 Colon Carcinoma Cell Line after Treatment with ,3,7,8- | zh_TW |
dc.relation.reference | Tetrachlorodibenzo-p-dioxin or 3-Methylcholanthrene.” Biochemical Pharmacology, | zh_TW |
dc.relation.reference | 56, 599-612. | zh_TW |
dc.relation.reference | Nadon, R. & Shoemaker, J. (2002) “Statistical issues with microarrays: processing and analysis”. Trends in Genetics, 18, 265-271. | zh_TW |
dc.relation.reference | Soric, B. (1989) “ Statistical “discoveries” and effect size estimation.” J. Am. Statist. Ass., 84, 608-610. | zh_TW |
dc.relation.reference | Simes, R. J. (1986) “An improved Bonferroni procedure for multiple tests of significance”. Biometrika, 73, 751-754. | zh_TW |
dc.relation.reference | Storey, J. D. & Tibshirani, R. (2003) “SAM thresholding and false discovery rates for detecting differential gene expression”. In The Analysis of Gene Expression Data: Methods and Software, by G Parmigiani, ES Garrett, RA Irizarry and SL Zeger (editors). Springer, New York. Available at http://www.stat.berkeley.edu/~storey/. | zh_TW |
dc.relation.reference | Tusher, V. G., Tibshirani, R., and Chu, G.(2001) “ Significance analysis of microarrays applied to the ionizing radiation response” Proc. Natl. Acad. Sci. USA, 98,5116-5121. | zh_TW |
dc.relation.reference | Yang, Y.H., Dudoit, S., Luu, P., and Speed, T.P. (2000) “Normalization for cDNA Microar-ray Data”. Technical report 589, Department of Statistics, University of California, Berkeley. Available at http://www.stat.berkeley.edu/users/terry/zarray | zh_TW |
dc.relation.reference | /Html/papersindex.html/. | zh_TW |
item.languageiso639-1 | en_US | - |
item.fulltext | With Fulltext | - |
item.openairetype | thesis | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_46ec | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | 學位論文 |
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