Please use this identifier to cite or link to this item:
https://ah.lib.nccu.edu.tw/handle/140.119/65828
DC Field | Value | Language |
---|---|---|
dc.contributor | 神科所 | en_US |
dc.creator | 詹銘煥 | zh_TW |
dc.creator | Chan, Ming-Huan ; Chung, Shiang-Sheng ; Stoker, Astrid K. ; Markou, Athina ; Chen, Hwei-Hsien | en_US |
dc.date | 2012.12 | en_US |
dc.date.accessioned | 2014-05-06T08:41:25Z | - |
dc.date.available | 2014-05-06T08:41:25Z | - |
dc.date.issued | 2014-05-06T08:41:25Z | - |
dc.identifier.uri | http://nccur.lib.nccu.edu.tw/handle/140.119/65828 | - |
dc.description.abstract | Toluene, a widely used and commonly abused organic solvent, produces various behavioral disturbances, including motor incoordination and cognitive impairment. Toluene alters the function of a large number of receptors and ion channels. Blockade of N-methyl-d-aspartate (NMDA) receptors has been suggested to play a critical role in toluene-induced behavioral manifestations. The present study determined the effects of various toluene doses on motor coordination, recognition memory, body temperature, and intracranial self-stimulation (ICSS) thresholds in mice. Additionally, the effects of sarcosine on the behavioral and physiological effects induced by toluene were evaluated. Sarcosine may reverse toluene-induced behavioral manifestations by acting as an NMDA receptor co-agonist and by inhibiting the effects of the type I glycine transporter (GlyT1). Mice were treated with toluene alone or combined with sarcosine pretreatment and assessed for rotarod performance, object recognition memory, rectal temperature, and ICSS thresholds. Toluene dose-dependently induced motor incoordination, recognition memory impairment, and hypothermia and lowered ICSS thresholds. Sarcosine pretreatment reversed toluene-induced changes in rotarod performance, novel object recognition, and rectal temperature but not ICSS thresholds. These findings suggest that the sarcosine-induced potentiation of NMDA receptors may reverse motor incoordination, memory impairment, and hypothermia but not the enhancement of brain stimulation reward function associated with toluene exposure. Sarcosine may be a promising compound to prevent acute toluene intoxications by occupational or intentional exposure. | en_US |
dc.format.extent | 293945 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | en_US | - |
dc.relation | Toxicology and Applied Pharmacology, 265(2), 158-165 | en_US |
dc.subject | Toluene; Motor coordination; Recognition memory; Body temperature; Intracranial self-stimulation | en_US |
dc.title | Sarcosine attenuates toluene-induced motor incoordination, memory impairment, and hypothermia but not brain stimulation reward enhancement in mice | en_US |
dc.type | article | en |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | restricted | - |
item.languageiso639-1 | en_US | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
Appears in Collections: | 期刊論文 |
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