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https://ah.lib.nccu.edu.tw/handle/140.119/72088
題名: | Reproducibility of microarray data: a further analysis of microarray quality control (MAQC) data | 作者: | Chen,James J. ;Hsueh, Huey-Miin ; Delongchamp, Robert R ; Lin, Chien-Ju ;Tsai, Chen-An 薛慧敏;蔡政安 |
貢獻者: | 統計系 | 日期: | Oct-2007 | 上傳時間: | 16-Dec-2014 | 摘要: | Many researchers are concerned with the comparability and reliability of microarray gene expression data. Recent completion of the MicroArray Quality Control (MAQC) project provides a unique opportunity to assess reproducibility across multiple sites and the comparability across multiple platforms. The MAQC analysis presented for the conclusion of inter- and intra-platform comparability/reproducibility of microarray gene expression measurements is inadequate. We evaluate the reproducibility/comparability of the MAQC data for 12901 common genes in four titration samples generated from five high-density one-color microarray platforms and the TaqMan technology. We discuss some of the problems with the use of correlation coefficient as metric to evaluate the inter- and intra-platform reproducibility and the percent of overlapping genes (POG) as a measure for evaluation of a gene selection procedure by MAQC. | 關聯: | BMC Bioinformatics. 2007; 8: 412. | 資料類型: | article | DOI: | http://dx.doi.org/10.1186/1471-2105-8-412 |
Appears in Collections: | 期刊論文 |
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