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https://ah.lib.nccu.edu.tw/handle/140.119/74028
題名: | Gestational exposure to polychlorinated biphenyls and dibenzofurans induced asymmetric hearing loss: Yucheng children study | 作者: | Li, Mingchieh; Wu, H.-P.; Yang, C.-Y.; Chen, P.-C.; Lambert, G.H.; Leon, Guo Y. 李銘杰 |
貢獻者: | 法科所 | 關鍵詞: | Polychlorinated dibenzofurans; Polychlorinated biphenyls; PCDFs; PCBs; Yucheng; Hearing loss; Prenatal; Gestational | 日期: | Feb-2015 | 上傳時間: | 25-Mar-2015 | 摘要: | Abstract\r\n\r\nIntroduction\r\n\r\nIn 1979, approximately 2000 people in central Taiwan were exposed to polychlorinated biphenyls and dibenzofurans (PCBs/PCDFs) due to ingestion of contaminated rice oil. The children born to mothers exposed to PCBs/PCDFs were called Yucheng children. We conducted a follow-up study to examine the association between gestational PCBs/PCDFS exposure and auditory function in Yucheng children`s early adulthood.\r\n\r\nMethods\r\n\r\nIn 1985 and early 1992, Yucheng children and their age, gender, socio-economic matched unexposed referent children were recruited for physical examination and long-term follow-ups. In 2007, Yucheng children and referent children were invited to participate in a health examination, including assessment of pure-tone air-conduction thresholds and distortion product otoacoustic emissions (DPOAEs) test. Gestational exposure to PCBs/PCDFs in Yucheng children were estimated by back-extrapolation of their mother`s serum concentration to the time of childbirth.\r\n\r\nResults\r\n\r\nA total of 86 Yucheng children (51.2% males) and 97 referent children (50.5% males) were included for analysis. No difference was found in demographic characteristics between two groups. Among the Yucheng children, 53 had estimated PCBs/PCDFs concentrations. We found that Yucheng children were at higher risk of having elevated hearing threshold at low frequencies in the right ear. Estimated maternal concentrations of 2,3,4,7,8-pnCDF at the time of birth were associated with increased hearing thresholds and decreased DPOAEs amplitudes at low frequencies in the right ear.\r\n\r\nConclusion\r\n\r\nGestational exposure to PCBs/PCDFs caused adverse asymmetrical hearing effects detectable even in early adulthood. | 關聯: | Environmental Research,137,65-71 | 資料類型: | article | DOI: | http://dx.doi.org/10.1016/j.envres.2014.12.002 |
Appears in Collections: | 期刊論文 |
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