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Title: Hyperhomocysteinaemia is associated with biochemical hyperandrogenaemia in women with reproductive age
Authors: Lin, Y.-H.;Huang, S.-Y.;Hsu, M.-I.;Chang, Y.-C.I.;Cheng, Chih Yu;Hsu, C.-S.;Tzeng, C.-R.
Contributors: 勞工研究所
Keywords: C reactive protein;homocysteine;adult;article;cardiovascular risk;controlled study;diastolic blood pressure;disease association;female;high risk patient;hirsutism;human;hyperandrogenism;hyperhomocysteinemia;insulin resistance;major clinical study;maternal age;metabolic disorder;modified Ferriman Gallwey score;oligomenorrhea;ovary polycystic disease;prevalence;priority journal;reproduction;scoring system;testosterone blood level;Hirsutism;Hyperandrogenism;Hyperhomocysteinaemia;Polycystic ovary syndrome;Adult;Body Mass Index;Case-Control Studies;Female;Humans;Hyperandrogenism;Hyperhomocysteinemia;Polycystic Ovary Syndrome;Risk Factors;Testosterone
Date: 2013
Issue Date: 2015-04-17 15:20:58 (UTC+8)
Abstract: Objective Hyperhomocysteinaemia is a well-established risk factor for cardiovascular disease. This study investigated the relationship between hyperhomocysteinaemia and factors related to polycystic ovary syndrome (PCOS). Study design Case-control study. Three hundred and thirty-nine women were included; of these, 84 had hyperhomocysteinaemia (homocysteine >12.4 μmol/l) and 255 had normal homocysteine levels. Homocysteine, high-sensitivity C-reactive protein, insulin resistance, metabolic disturbance and PCOS-related disturbance were evaluated. The clinical and biochemical characteristics of women with hyperhomocysteinaemia and normal homocysteine levels, including insulin resistance, metabolic disturbance and PCOS-related disturbance, were compared. Results Correlation was found between serum homocysteine level and serum total testosterone level and diastolic blood pressure. No correlation was found between serum homocysteine level and age, body mass index, insulin resistance and lipid profile. Women with hyperhomocysteinaemia had a significantly higher risk for biochemical hyperandrogenaemia and higher serum total testosterone levels than women with normal homocysteine levels. The prevalence rates of PCOS, oligo-amenorrhoea, polycystic ovary morphology and metabolic disturbance did not differ between the two groups. The parameters of insulin resistance and lipid profiles were similar between the two groups, and signs of clinical hyperandrogenism (hirsutism and the modified Ferriman-Gallwey score) did not differ between the two groups. Logistic regression analysis found a significant association between hyperandrogenaemia and hyperhomocysteinaemia (odds ratio 2.24, 95% confidence interval 1.26-4.01). Conclusions For women with PCOS, an elevated serum total testosterone level is the main factor associated with hyperhomocysteinaemia. The association between biochemical hyperandrogenism and hyperhomocysteinaemia may contribute to cardiovascular risk for women with PCOS. © 2013 Elsevier Ireland Ltd © 2013 Published by Elsevier Ireland Ltd. All rights reserved.
Relation: European Journal of Obstetrics Gynecology and Reproductive Biology,Volume 171( 2), Pages 314-318
Data Type: article
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