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https://ah.lib.nccu.edu.tw/handle/140.119/75233
題名: | Hepatitis B viral factors and treatment responses in chronic hepatitis B | 作者: | Lin, Chih-Lin 林志陵 Kao, J.-H. |
貢獻者: | 心理系 | 關鍵詞: | adefovir; adefovir dipivoxil; alanine aminotransferase; alpha interferon; creatinine; entecavir; hepatitis B surface antigen; lamivudine; peginterferon alpha; peginterferon alpha2a; peginterferon alpha2b; telbivudine; tenofovir disoproxil; virus DNA; antiviral resistance; antiviral therapy; clinical effectiveness; competitive inhibition; creatinine blood level; disease association; disease exacerbation; drug efficacy; drug half life; genotype; hepatitis B; Hepatitis B virus; human; liver cirrhosis; monotherapy; mutational analysis; nephrotoxicity; predictive value; review; risk factor; seroconversion; side effect; treatment duration; treatment response; viremia; virus strain; Antiviral Agents; DNA, Viral; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Polyethylene Glycols; Recombinant Proteins | 日期: | Jun-2013 | 上傳時間: | 21-May-2015 | 摘要: | Baseline and on-treatment hepatitis B viral factors are reported to affect treatment responses. A lower baseline hepatitis B virus (HBV) DNA level is a strong predictor of the response to antiviral therapy. HBV genotype A/B patients have better responses to interferon-based therapy than those with genotypes C/D. Regarding the association of HBV mutants with responses to antiviral therapy, current evidence is limited. On-treatment viral suppression is the most important predictor of response to nucleoside analogs. On-treatment hepatitis B surface antigen decline is significantly associated with response to pegylated interferon. In the future, individualized therapy should be based on treatment efficacy, adverse effects, baseline and on-treatment predictors of antiviral therapy. © 2012, Elsevier Taiwan LLC & Formosan Medical Association. | 關聯: | Journal of the Formosan Medical Association, 112(6), 302-311 | 資料類型: | article | DOI: | http://dx.doi.org/10.1016/j.jfma.2013.02.001 |
Appears in Collections: | 期刊論文 |
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