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https://ah.lib.nccu.edu.tw/handle/140.119/99016
題名: | Neuroprotective mechanism of glial cell line-derived neurotrophic factor on dopamine neurons: effects on antioxidation. | 作者: | 趙知章 CC, Chao;EHY, Lee |
貢獻者: | 神科所 | 關鍵詞: | Glial cell line-derived neurotrophic factor; Glutathione peroxidase; Superoxide dismutase; Catalase; Dopamine; 1-Methyl-4-phenylpyridinium | 日期: | 1999 | 上傳時間: | 13-Jul-2016 | 摘要: | Recombinant human GDNF was infused into the rat striatum either acutely or subchronically. Its effects and its interactions with MPP+ on antioxidant enzyme activities were examined. Results indicated that acute GDNF infusion significantly increased glutathione peroxidase, superoxide dismutase and catalase activities. Subchronic GDNF treatment decreased the DA level and enhanced DA turnover. Pre-treatment with GDNF markedly protected DA neurons against MPP+-induced toxicity. These results suggest that GDNF protects DA neurons through its activation of the antioxidant enzyme systems. | 關聯: | Neuropharmacol., 38(6), 913-916 | 資料類型: | article | DOI: | http://dx.doi.org/10.1016/S0028-3908(99)00030-1 |
Appears in Collections: | 期刊論文 |
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