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題名 促進成年神經新生之藥物對大鼠海馬迴及其學習記憶的影響
A compound that promotes adult neurogenesis in the hippocampus enhances learning and memory
作者 吳佩融
貢獻者 賴桂珍
吳佩融
關鍵詞 神經新生
海馬迴
豐富性環境
日期 2016
上傳時間 2-九月-2016 00:14:50 (UTC+8)
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描述 碩士
國立政治大學
神經科學研究所
102754006
資料來源 http://thesis.lib.nccu.edu.tw/record/#G0102754006
資料類型 thesis
dc.contributor.advisor 賴桂珍zh_TW
dc.contributor.author (作者) 吳佩融zh_TW
dc.creator (作者) 吳佩融zh_TW
dc.date (日期) 2016en_US
dc.date.accessioned 2-九月-2016 00:14:50 (UTC+8)-
dc.date.available 2-九月-2016 00:14:50 (UTC+8)-
dc.date.issued (上傳時間) 2-九月-2016 00:14:50 (UTC+8)-
dc.identifier (其他 識別碼) G0102754006en_US
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/101132-
dc.description (描述) 碩士zh_TW
dc.description (描述) 國立政治大學zh_TW
dc.description (描述) 神經科學研究所zh_TW
dc.description (描述) 102754006zh_TW
dc.description.tableofcontents 中文摘要
     英文摘要
     縮寫對照表
     第一章-緒論
     一、成體的神經新生(Adult neurogenesis)
     1-1 神經新生------------------------------------- 1
     1-2 促進神經新生的因子----------------------------- 4
     1-3 Shh(Sonic hedgehog) ------------------------ 5
     (1) 由系統演化樹看Shh的演化
     (2) Sonic hedgehog (Shh) 的蛋白質構造
     (3) Shh的訊號傳遞路徑
     二、海馬迴(hippocampus)
     2-1 海馬迴的解剖構造-------------------------------- 9
     2-2 海馬迴的訊息路徑及學習記憶----------------------- 10
     2-3 海馬迴相關的學習記憶行為實驗--------------------- 14
     三、微小膠細胞(microglia) -------------------------- 14
     四、腎上腺摘除手術(Adrenalectomy)的影響
     4-1 腎上腺(Adrenal gland) ------------------------ 17
     4-2下視丘-腦垂腺-腎上腺軸---------------------------- 18
     4-3 腎上腺摘除手術(Adrenalectomy) ----------------- 20
     五、使用立刻表現基因(immediate-early gene, IEG)來觀察細胞
      活化情形
     5-1 立即表現基因(immediate-early gene, IEG) ------- 21
     5-2 Arc (Activity-regulated cytoskeletal associated protein)- 23 第二章、研究目標------------------------ 25
     第三章、材料方法------------------------------------- 26
     3-1 實驗流程圖-------------------------------------- 26
     3-2 實驗動物---------------------------------------- 26
     3-3 實驗儀器---------------------------------------- 27
     3-4 腎上腺摘除手術(Adrenalectomy) ------------------- 27
     3-5皮質固醇Corticosterone (CORT) ------------------- 29
     3-6 Prime pump------------------------------------- 29
     3-7 立體定位手術(Stereotaxic surgery)及埋管----------- 31
     3-8 術後環境---------------------------------------- 33
     3-9 行為實驗---------------------------------------- 33
     3-10腦組織的灌流製備與切片--------------------------- 36
     3-11腦組織染色(Immunohistochemistry,IHC) ----------- 37
     3-12封片膠的製備------------------------------------ 38
     3-13切片細胞計數分析軟體----------------------------- 39
     3-14行為結果分析------------------------------------ 39
     第四章、 結果
     4-1 摘除腎上腺後ADX與Sham細胞體積比較-------------- 40
     4-2 短時間給予dellta s後觀察對老鼠海馬迴細胞的影響--- 42
     4-3 長時間給予delta s 後的物體辨識行為------------- 61
     4-4 新生成的神經細胞是否參與行為------------------- 65
     4-5 ADX後給予delta s 及Shh的比較----------------- 76
     第五章、 討論------------------------------------ 78
     第六章、 結論------------------------------------ 80
     文獻---------------------------------------- 82		zh_TW
dc.source.uri (資料來源) http://thesis.lib.nccu.edu.tw/record/#G0102754006en_US
dc.subject (關鍵詞) 神經新生zh_TW
dc.subject (關鍵詞) 海馬迴zh_TW
dc.subject (關鍵詞) 豐富性環境zh_TW
dc.title (題名) 促進成年神經新生之藥物對大鼠海馬迴及其學習記憶的影響zh_TW
dc.title (題名) A compound that promotes adult neurogenesis in the hippocampus enhances learning and memoryen_US
dc.type (資料類型) thesisen_US
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