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題名 Physical mechanism for biopolymers to aggregate and maintain in non-equilibrium states
作者 馬文忠
胡進錕
Ma, Wen-Jong
Hu, Chin-Kun
貢獻者 應物所
關鍵詞 Biological physics ; Molecular modelling
日期 2017-06
上傳時間 16-十月-2017 12:10:49 (UTC+8)
摘要 Many human or animal diseases are related to aggregation of proteins. A viable biological organism should maintain in non-equilibrium states. How protein aggregate and why biological organisms can maintain in non-equilibrium states are not well understood. As a first step to understand such complex systems problems, we consider simple model systems containing polymer chains and solvent particles. The strength of the spring to connect two neighboring monomers in a polymer chain is controlled by a parameter s with s → ∞ for rigid-bond. The strengths of bending and torsion angle dependent interactions are controlled by a parameter s A with s A  → -∞ corresponding to no bending and torsion angle dependent interactions. We find that for very small s A , polymer chains tend to aggregate spontaneously and the trend is independent of the strength of spring. For strong springs, the speed distribution of monomers in the parallel (along the direction of the spring to connect two neighboring monomers) and perpendicular directions have different effective temperatures and such systems are in non-equilibrium states.
關聯 Scientific Report, Vol.7, pp.3105
資料類型 article
DOI http://dx.doi.org/10.1038/s41598-017-03136-7
dc.contributor 應物所
dc.creator (作者) 馬文忠zh-TW
dc.creator (作者) 胡進錕zh-TW
dc.creator (作者) Ma, Wen-Jongen-US
dc.creator (作者) Hu, Chin-Kunen-US
dc.date (日期) 2017-06
dc.date.accessioned 16-十月-2017 12:10:49 (UTC+8)-
dc.date.available 16-十月-2017 12:10:49 (UTC+8)-
dc.date.issued (上傳時間) 16-十月-2017 12:10:49 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/113627-
dc.description.abstract (摘要) Many human or animal diseases are related to aggregation of proteins. A viable biological organism should maintain in non-equilibrium states. How protein aggregate and why biological organisms can maintain in non-equilibrium states are not well understood. As a first step to understand such complex systems problems, we consider simple model systems containing polymer chains and solvent particles. The strength of the spring to connect two neighboring monomers in a polymer chain is controlled by a parameter s with s → ∞ for rigid-bond. The strengths of bending and torsion angle dependent interactions are controlled by a parameter s A with s A  → -∞ corresponding to no bending and torsion angle dependent interactions. We find that for very small s A , polymer chains tend to aggregate spontaneously and the trend is independent of the strength of spring. For strong springs, the speed distribution of monomers in the parallel (along the direction of the spring to connect two neighboring monomers) and perpendicular directions have different effective temperatures and such systems are in non-equilibrium states.en_US
dc.format.extent 4792872 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) Scientific Report, Vol.7, pp.3105zh_TW
dc.subject (關鍵詞) Biological physics ; Molecular modellingen_US
dc.title (題名) Physical mechanism for biopolymers to aggregate and maintain in non-equilibrium statesen_US
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.1038/s41598-017-03136-7
dc.doi.uri (DOI) http://dx.doi.org/10.1038/s41598-017-03136-7