| dc.contributor | 心理系 | |
| dc.creator (作者) | Wu, Yi-Fan;Su, Ming-Wei;Chiang, Bor-Luen;Yang, Yao-Hsu;Tsai, Ching-Hui;Lee, Yungling L. | en_US |
| dc.creator (作者) | Wu, Yi-Fan | en_US |
| dc.date (日期) | 2017-12 | |
| dc.date.accessioned | 18-九月-2018 15:55:28 (UTC+8) | - |
| dc.date.available | 18-九月-2018 15:55:28 (UTC+8) | - |
| dc.date.issued (上傳時間) | 18-九月-2018 15:55:28 (UTC+8) | - |
| dc.identifier.uri (URI) | https://ah.lib.nccu.edu.tw/item?item_id=138046 | - |
| dc.description.abstract (摘要) | BACKGROUND: \n\nInhaled corticosteroids are recommended as the first-line controller medication for childhood asthma owing to their multiple clinical benefits. However, heterogeneity in the response towards these drugs remains a significant clinical problem.\n\nMETHODS: \n\nChildren aged 5 to 18 years with mild to moderate persistent asthma were recruited into the Taiwanese Consortium of Childhood Asthma Study. Their responses to inhaled corticosteroids were assessed based on their improvements in the asthma control test and peak expiratory flow. The predictors of responsiveness were demographic and clinical features that were available in primary care settings. We have developed a prediction model using logistic regression and have simplified it to formulate a practical tool. We assessed its predictive performance using the area under the receiver operating characteristic curve.\n\nRESULTS: \n\nOf the 73 asthmatic children with baseline and follow-up outcome measurements for inhaled corticosteroids treatment, 24 (33%) were defined as non-responders. The tool we have developed consisted of three predictors yielding a total score between 0 and 5, which are comprised of the following parameters: the age at physician-diagnosis of asthma, sex, and exhaled nitric oxide. Sensitivity and specificity of the tool for prediction of inhaled corticosteroids non-responsiveness, for a score of 3, were 0.75 and 0.69, respectively. The areas under the receiver operating characteristic curve for the prediction tool was 0.763.\n\nCONCLUSIONS: \n\nOur prediction tool represents a simple and low-cost method for predicting the response of inhaled corticosteroids treatment in asthmatic children. | en_US |
| dc.format.extent | 413021 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | BMC Pulmonary Medicine, 17, 176 | |
| dc.relation (關聯) | PMID: 29216859 | |
| dc.subject (關鍵詞) | Childhood asthma; Drug response; Inhaled corticosteroid; Prediction model | en_US |
| dc.title (題名) | A simple prediction tool for inhaled corticosteroid response in asthmatic children | en_US |
| dc.type (資料類型) | article | |
| dc.identifier.doi (DOI) | 10.1186/s12890-017-0533-0 | |
| dc.doi.uri (DOI) | https://doi.org/10.1186/s12890-017-0533-0 | |
