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題名 Inositol hexaphosphate modulates the behavior of macrophages through alteration of gene expression involved in pathways of pro- and anti-inflammatory responses, and resolution of inflammation pathways
作者 陳紹寬
Chen, Shau-Kwaun
Wee, Yinshen
Yang, Chieh-Hsiang
Yen, Yu-Chun
Wang, Ching-Shuen
貢獻者 神科所
日期 2021-06
上傳時間 27-十月-2021 10:56:50 (UTC+8)
摘要 Inositol hexaphosphate (IP6) is a dietary compound commonly obtained from corn, rice, etc. Although we may consume significant amount of IP6 daily, it is unclear whether this diet will impact macrophages’ fate and function. Therefore, we characterized the underlying relationship between IP6 and macrophage polarization in this study. We specifically examined the signature gene expression profiles associated with pro- and anti-inflammatory responses, and resolution of inflammation pathways in macrophages under the influence of IP6. Interestingly, our data suggested that IP6 polarizes bone marrow-derived macrophages (BMDM) into an M2a-like subtype. Our results also demonstrated that IP6 reduces lipopolysaccharide-induced apoptosis and pro-inflammatory responses in macrophages. In contrast, the expression levels of genes related to anti-inflammatory responses and resolution of inflammation pathways are upregulated. Our findings collectively demonstrated that IP6 has profound modulation effects on macrophages, which warrant further research on the therapeutic benefits of IP6 for inflammatory diseases.
關聯 Food Science and Nutrition, 9:6, 3240-3249
資料類型 article
DOI https://doi.org/10.1002/fsn3.2286
dc.contributor 神科所
dc.creator (作者) 陳紹寬
dc.creator (作者) Chen, Shau-Kwaun
dc.creator (作者) Wee, Yinshen
dc.creator (作者) Yang, Chieh-Hsiang
dc.creator (作者) Yen, Yu-Chun
dc.creator (作者) Wang, Ching-Shuen
dc.date (日期) 2021-06
dc.date.accessioned 27-十月-2021 10:56:50 (UTC+8)-
dc.date.available 27-十月-2021 10:56:50 (UTC+8)-
dc.date.issued (上傳時間) 27-十月-2021 10:56:50 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/137549-
dc.description.abstract (摘要) Inositol hexaphosphate (IP6) is a dietary compound commonly obtained from corn, rice, etc. Although we may consume significant amount of IP6 daily, it is unclear whether this diet will impact macrophages’ fate and function. Therefore, we characterized the underlying relationship between IP6 and macrophage polarization in this study. We specifically examined the signature gene expression profiles associated with pro- and anti-inflammatory responses, and resolution of inflammation pathways in macrophages under the influence of IP6. Interestingly, our data suggested that IP6 polarizes bone marrow-derived macrophages (BMDM) into an M2a-like subtype. Our results also demonstrated that IP6 reduces lipopolysaccharide-induced apoptosis and pro-inflammatory responses in macrophages. In contrast, the expression levels of genes related to anti-inflammatory responses and resolution of inflammation pathways are upregulated. Our findings collectively demonstrated that IP6 has profound modulation effects on macrophages, which warrant further research on the therapeutic benefits of IP6 for inflammatory diseases.
dc.format.extent 954806 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) Food Science and Nutrition, 9:6, 3240-3249
dc.title (題名) Inositol hexaphosphate modulates the behavior of macrophages through alteration of gene expression involved in pathways of pro- and anti-inflammatory responses, and resolution of inflammation pathways
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.1002/fsn3.2286
dc.doi.uri (DOI) https://doi.org/10.1002/fsn3.2286