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題名 Dopamine Receptor Antagonists Reverse Amphetamine-Induced Behavioral Alteration on a Differential Reinforcement for Low-rate (DRL) Operant Task in the Rat 作者 Cheng, Ruey-Kuang
Liao, Ruey-Ming
廖瑞銘貢獻者 國立政治大學心理學系 關鍵詞 D1 and D2 receptors; IRT analysis; psychostimulant; raclopride; SCH23390; timing behavior 日期 2007-04 上傳時間 29-十二月-2008 15:34:16 (UTC+8) 摘要 Previous studies have shown that amphetamine significantly alters operant responding on the behavior maintained on a schedule of differential reinforcement of low-rate (DRL). As such, behavioral deficiency of DRL responding has been observed by the drug-induced increase of non-reinforced responses and a leftward shift of inter-response time (IRT) curve on DRL responding in the rat. However, the neurochemical basis for amphetamine-induced DRL behavioral alternations remain to be elucidated. The present study was then designed to examine whether the effects of amphetamine were dependent on dopamine-subtyped receptors, this was carried out by the co-administration of the selective D1 and D2 receptor antagonists, SCH23390 and raclopride respectively. Rats were first trained to perform on DRL 10-sec task and then divided into four groups, which received separate types of double injections before the behavioral session. The four groups were the saline control group, the amphetamine alone group, the dopamine antagonist alone group, and the combination amphetamine and dopamine antagonist group. The saline control group performed DRL responding in an efficient manner with a major index for the peak time of the IRT curve, which was fairly localized within the 10-sec bin throughout the test phase. The subjects injected with amphetamine (1 mg/kg) significantly shortened IRT that led to a leftward shift of IRT curve, which was further revealed by a decreased peak time without significant effectiveness on the peak rate and burst response. Even though the group given SCH23390 or raclopride alone showed profound disruption on DRL behavior by flattening the IRT curve, the co-administration of amphetamine with SCH23390 or raclopride reversed the aforementioned amphetamine-induced behavioral deficiency on DRL task. Together, these results suggest that the dopamine D1 and D2 receptors are involved and important to the temporal regulation of DRL response under psychostimulant drug treatment. Furthermore, this highlights the involvement of the brain dopamine systems in the temporal regulation of DRL behavior performance. 關聯 Chinese Journal of Physiology, 50(2) , 77-88 資料類型 article dc.contributor 國立政治大學心理學系 en_US dc.creator (作者) Cheng, Ruey-Kuang en_US dc.creator (作者) Liao, Ruey-Ming en_US dc.creator (作者) 廖瑞銘 en_US dc.date (日期) 2007-04 en_US dc.date.accessioned 29-十二月-2008 15:34:16 (UTC+8) - dc.date.available 29-十二月-2008 15:34:16 (UTC+8) - dc.date.issued (上傳時間) 29-十二月-2008 15:34:16 (UTC+8) - dc.identifier.uri (URI) https://nccur.lib.nccu.edu.tw/handle/140.119/19814 - dc.description.abstract (摘要) Previous studies have shown that amphetamine significantly alters operant responding on the behavior maintained on a schedule of differential reinforcement of low-rate (DRL). As such, behavioral deficiency of DRL responding has been observed by the drug-induced increase of non-reinforced responses and a leftward shift of inter-response time (IRT) curve on DRL responding in the rat. However, the neurochemical basis for amphetamine-induced DRL behavioral alternations remain to be elucidated. The present study was then designed to examine whether the effects of amphetamine were dependent on dopamine-subtyped receptors, this was carried out by the co-administration of the selective D1 and D2 receptor antagonists, SCH23390 and raclopride respectively. Rats were first trained to perform on DRL 10-sec task and then divided into four groups, which received separate types of double injections before the behavioral session. The four groups were the saline control group, the amphetamine alone group, the dopamine antagonist alone group, and the combination amphetamine and dopamine antagonist group. The saline control group performed DRL responding in an efficient manner with a major index for the peak time of the IRT curve, which was fairly localized within the 10-sec bin throughout the test phase. The subjects injected with amphetamine (1 mg/kg) significantly shortened IRT that led to a leftward shift of IRT curve, which was further revealed by a decreased peak time without significant effectiveness on the peak rate and burst response. Even though the group given SCH23390 or raclopride alone showed profound disruption on DRL behavior by flattening the IRT curve, the co-administration of amphetamine with SCH23390 or raclopride reversed the aforementioned amphetamine-induced behavioral deficiency on DRL task. Together, these results suggest that the dopamine D1 and D2 receptors are involved and important to the temporal regulation of DRL response under psychostimulant drug treatment. Furthermore, this highlights the involvement of the brain dopamine systems in the temporal regulation of DRL behavior performance. - dc.format application/ en_US dc.language en en_US dc.language en-US en_US dc.language.iso en_US - dc.relation (關聯) Chinese Journal of Physiology, 50(2) , 77-88 en_US dc.subject (關鍵詞) D1 and D2 receptors; IRT analysis; psychostimulant; raclopride; SCH23390; timing behavior - dc.title (題名) Dopamine Receptor Antagonists Reverse Amphetamine-Induced Behavioral Alteration on a Differential Reinforcement for Low-rate (DRL) Operant Task in the Rat en_US dc.type (資料類型) article en
