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題名 Differential effects of diazepam infused into the amygdala and hippocampus on negative contrast
作者 Liao, Ruey-Ming
Chuang, Feng-Jung
日期 2003-03
上傳時間 31-十二月-2008 11:05:06 (UTC+8)
摘要 Behavioral suppression is observed when animals shift from a high to a lower magnitude of reward in comparison to animals that continuously receive the lower magnitude reward. As previously reported, systemic administration of benzodiazepines promotes recovery from this negative contrast. This study aimed to assess where the neural substrate(s) located in the limbic areas for diazepam to induce such recovery effects on negative contrast. With food-deprived rats, the negative contrast procedure was conducted by comparing a group consuming a 32% sucrose solution which was shifted to 4% with a group consuming only 4% sucrose throughout the experiment. Represented mainly by a decreased number of licks, the negative contrast effects were clearly shown in the control groups receiving the vehicle. Systemic injection of diazepam dose-dependently reduced this contrast. Further, this negative contrast effect was significantly attenuated by local infusion of diazepam (30 microg) into the amygdala, but no such effect was confirmed when diazepam was infused into the hippocampus. Together, the present study shows that a reliable anti-contrast effect can be induced by diazepam administration peripherally or locally infused into the amygdala. These data indicate that the amygdala is involved in the recovery effects of benzodiazepines on consummatory negative contrast.
關聯 Pharmacology biochemistry and behavior, 74, 953-960
資料類型 article
DOI http://dx.doi.org/10.1016/S0091-3057(03)00023-6
dc.creator (作者) Liao, Ruey-Mingen_US
dc.creator (作者) Chuang, Feng-Jungen_US
dc.date (日期) 2003-03en_US
dc.date.accessioned 31-十二月-2008 11:05:06 (UTC+8)-
dc.date.available 31-十二月-2008 11:05:06 (UTC+8)-
dc.date.issued (上傳時間) 31-十二月-2008 11:05:06 (UTC+8)-
dc.identifier.uri (URI) https://nccur.lib.nccu.edu.tw/handle/140.119/20981-
dc.description.abstract (摘要) Behavioral suppression is observed when animals shift from a high to a lower magnitude of reward in comparison to animals that continuously receive the lower magnitude reward. As previously reported, systemic administration of benzodiazepines promotes recovery from this negative contrast. This study aimed to assess where the neural substrate(s) located in the limbic areas for diazepam to induce such recovery effects on negative contrast. With food-deprived rats, the negative contrast procedure was conducted by comparing a group consuming a 32% sucrose solution which was shifted to 4% with a group consuming only 4% sucrose throughout the experiment. Represented mainly by a decreased number of licks, the negative contrast effects were clearly shown in the control groups receiving the vehicle. Systemic injection of diazepam dose-dependently reduced this contrast. Further, this negative contrast effect was significantly attenuated by local infusion of diazepam (30 microg) into the amygdala, but no such effect was confirmed when diazepam was infused into the hippocampus. Together, the present study shows that a reliable anti-contrast effect can be induced by diazepam administration peripherally or locally infused into the amygdala. These data indicate that the amygdala is involved in the recovery effects of benzodiazepines on consummatory negative contrast.-
dc.format application/en_US
dc.language enen_US
dc.language en-USen_US
dc.language.iso en_US-
dc.relation (關聯) Pharmacology biochemistry and behavior, 74, 953-960en_US
dc.title (題名) Differential effects of diazepam infused into the amygdala and hippocampus on negative contrasten_US
dc.type (資料類型) articleen
dc.identifier.doi (DOI) 10.1016/S0091-3057(03)00023-6en_US
dc.doi.uri (DOI) http://dx.doi.org/10.1016/S0091-3057(03)00023-6en_US