學術產出-學位論文

題名 以疾病為導向之醫療風險管理-以心臟冠狀動脈繞道手術為例
Disease-oriented control of medical risks- analyzed with coronary artery bypass grafting surgery
作者 程毅君
Cherng, Yih-Giun
貢獻者 蔡政憲
Tsai, Chenghsien
程毅君
Cherng, Yih-Giun
關鍵詞 冠狀動脈繞道手術
體外循環
罹病率
死亡率
Coronary artery bypass grafting surgery
Cardiopulmonary bypass
Morbidity rate
Mortality rate
EuroScore
日期 2005
上傳時間 2009-09-18
摘要 背景與目的:
每一項疾病都有其潛在的風險,但要有效的降低死亡率及併發症發生率,必須找出關鍵性指標加以改善或預防。我們以心臟冠狀動脈繞道手術之患者為例,希望藉由統計分析的方式,找出造成死亡以及術後併發症最相關的因素,目的不只在預測,而在於防範。

研究對象與方法:
在我們的實驗設計上,風險因子分布在手術前、手術中、以及手術後三個階段,對象是某醫學中心接受心臟冠狀動脈繞道手術的220例患者。分析採用迴歸統計建立模型,其中羅吉斯迴歸中的依變數為死亡率與罹病率,線性迴歸的依變數為加護病房留置天數以及總住院日數。ROC curve亦將被建立,以判斷模型是否能區別病患是否罹病或死亡。所得資料亦計算EuroScore及其ROC曲線面積,並與歷史資料做比較。

結果:
所建立的死亡估計模型的有兩個,預測值都在97%以上,ROC曲線面積亦都超過0.96;併發症估計模型由六個變數所構成,預測率及ROC曲線面積分別為94%和0.984。加護病房留置天數及住院天數估計模型分別由八個及十三個因子來解釋,調整後的R square分別為0.527及0.6。EuroScore對死亡與併發症的預測率,分別為93.7%和82%,ROC曲線面積分別是0.864和0.797,均高於歷史文獻記錄,未來應該廣泛應用。

結論與建議:
經由適當的風險分級和危險因子分析,我們可以找出風險高低的標準和依據,了解影響死亡率與罹病率的關鍵因子是什麼,儘可能的做事前的防範與處置,希望能夠改善結果並提高手術的存活率。
EuroScore是個值得採用的預測工具,可以廣泛應用在死亡率與併發症發生率的估計,但是必須搭配風險因子的改善,才能發揮實際的功效。我們認為,體外循環時間與再次手術是最具有空間來降低死亡率與罹病率的兩個要素,有效率的控制時間、改善造成再手術的前因後果,除了死亡率與併發症發生率的下降外,還可以及早脫離對加護病房照顧的需求並減少留置的天數。
參考文獻 1. Prabhakar G, Haan CK, Peterson ED, Coombs LP, Cruzzavala JL, Murray GF. The risks of moderate and extreme obesity for coronary artery grafting outcomes: a study from the society of Thoracic Surgeon"s database. Ann Thorac Surg. 2002; 74: 1125-31.
2. Ivert T, Sandberg E, Hammar N. Obesity doesn"t increase the risks of coronary surgery: results from a study of 7,248 patients who underwent the surgery. Lakartidningen. 2000; 97: 972-4.
3. Reeves BC, Ascione R, Chamberlain MH, Angelini GD. Effect of body mass index on early outcome in patients undergoing coronary artery bypass surgery. J Am Coll Cardiol. 2003; 42: 668-76.
4. Ruyun Jin, Grunkemeier GL, Furnary AP, Handy Jr JR. Is obesity a risk factor for mortality in coronary artery bypass surgery? Circulation. 2005; 111: 3359-65.
5. Mohan R, Amsel BJ, Walter PJ. Coronary artery bypass grafting in the elderly: a review of studies on patients older than 64, 69 or 74 years. Cardiology. 1992; 80: 21-25.
6. Peterson ED, Jollis JG, Bebchuk JD. Changes in mortality after myocardial revascularization in the elderly: the national medical experience. Ann Intern Med. 1994; 121: 919-27.
7. Graham MM, Ghali WA, Faris PD, Galbraith PD, Norris CM, Knudtson ML. Survival after coronary revascularization in the elderly. Circulation. 2002; 105: 2378-84.
8. Zaidi AM, Fitzpatrick AP, Keenan DJM, Odom NJ, Grotte GJ. Good outcome from cardiac surgery in the over 70s. Heart. 1999; 82: 134-7.
9. Smith KM, Lamy A, Arthur HM, Gafni A, Kent R. Outcomes and costs of coronary artery bypass grafting: comparison between octogenarians and septuagenarians at a tertiary care center. Can Med Asso J. 2001; 165(6): 759-64.
10. Edwards FH, Carey JS, Grover FL, Bero JW, Hartz RS. Impact of gender on coronary bypass operative mortality. Ann Thorac Surg. 1998; 66: 125-31.
11. Hogue CW, Thoralf Sundt, Benico Barzilai, Schecthman KB, Dávila-Román VG. Cardiac and neurologic complications identify risks for mortality for both men and women undergoing coronary artery bypass graft surgery. Anesthesiology. 2001; 95: 1074-8.
12. Blankstein R, Ward RP, Arnsdrof M, Jones B, Lou YB, Pine M. Female gender is an independent predictor of operative mortality after coronary artery bypass graft surgery. Circulation. 2005; 112(suppl I): 323-7.
13. Psaty BM, Heckbert SR, Koepsell TD. The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA. 1995; 274: 620-5.
14. Fuberg CD, Psaty BM, Meyer JV. Nifedipine: dose-related increase in mortality in patients with coronary artery disease. Circulation. 1995; 92: 1326-31.
15. Weightman WM, Gibbs NM, Sheminant MR, Whitford EG, Mahon BD, Newman MAJ. Drug therapy before coronary artery surgery: nitrates are independent predictors of mortality and b-adrenergic blockers predict survival. Anesth Analg. 1999; 88: 286-91.
16. Ferguson TB, Coombs LP, Peterson ED. Preoperative use b-blockers and mortality and morbidity following CABG surgery in North America. JAMA. 2002; 287: 2221-7.
17. ten Broecke PWC, De Hert SG, Mertens E, Adriaensen HF. Effect of preoperative b-blockade on perioperative mortality in coronary surgery. BJA. 2003; 90(1): 27-31.
18. DeFrances CJ, Hall MJ. 2002 National hospital discharge survey. Adv Data. 2004: 1-29.
19. Gandhi GY, Nuttall GA, Abel MD, Mullany CJ, Schaff HV, Williams BA, Schrader LM, Rizza RA, Molly McMahon M. Intraoperative hyperglycemia and perioperative outcomes in cardiac surgery patients. Mayo Clin Proc. 2005; 80(7): 862-6.
20. Morricone L, Rannucci M, Cazzaniga SDA, Isgró G, Enrini R, Caviezel F. Diabetes and complications after cardiac surgery: comparison with a non-diabetic population. Acta Diabetol. 1999; 36: 77-84.
21. Braith RW, Welsch MA, Feigenbaum MS. Neuroendocrine activation in the heart failure is modified by endurance exercise training. J Am Coll Cardiol. 1999; 34: 1170-5.
22. Dimopoulou I, Daganou M, Tsintzas OK. Effects of severity of long-standing congestive heart failure on pulmonary function. Respir Med. 1998; 92: 1321-25.
23. Johnson BD, Beck KC, Olson LJ, O"Malley KA, Allison TG, Squires RW, Gau GT. Pulmonary function in patients with reduced left ventricular function. Influence of smoking and cardiac surgery. Chest. 2001; 120: 1869-76.
24. Mazzarella V, Gallucci MT, Tozzo C. Renal function in patients undergoing cardiopulmonary bypass operations. J Thorac Cardiovasc Surg. 1992; 104: 1625-7.
25. Mangano CM, Diamondstone LS, Ramsay JG. Renal dysfunction after myocardial revascularization: risk factors, adverse outcomes, and hospital resource utilization. Ann Intern Med. 1998; 128: 194-203.
26. Ryckwaert F, Boccara G, Frappier JM, Colson PH. Incidence, risk factors, and prognosis of a moderate increase in plasma creatinine early after cardiac surgery. Crit Care Med. 2002; 30: 1495-8.
27. Bechtel M, Fischlein T, Krabatsch T, Nägele H, Osswald B, Schönburg M, Scholz F, Stamm C, Stripling J, Sievers H, Bartels C. An analysis of the risk factors for perioperative mortality in patients with end-stage renal failure undergoing cardiac surgery: a multicenter study. Thorac ardiovasc Surg. 2005; 53:
28. Holmes JH, Connolly NC, Hill ME, Guyton SW, Hall RA. Magnitude of the inflammatory response to cardiopulmonary bypass and its relation to adverse clinical outcomes. Inflamm Res. 2002; 51: 579-86.
29. Miller BE, Guzzetta NA, Tosone SR, Levy JH. Rapid evaluation of coagulopathies after cardiopulmonary bypass in children using modified thromboelastography. Anesth Analg. 2000; 90(6): 1324-30.
30. Habib RH, Anoar Zacharias, Schwann TA, Riordan CJ, Milo Engoren, Durham SJ, Aamir Shah. Role of hemodilutional anemia and transfusion during cardiopulmonary bypass in renal injury after coronary revascularization: implications on operative outcome. Crit Care Med. 2005; 33: 1749-56.
31. McSweeney ME, Susan Garwood, Jack Levin, marino MR, Wang SX, David kardatzke, mangano DT, Wolman RL. Adverse gastrointestinal complications after cardiopulmonary bypass: can outcome be predicted from preoperative risk factors? Anesth Analg. 2004; 98: 1610-7.
32. Murkin JM. Etiology and incidence of brain dysfunction after cardiac surgery. J Cardiothorac Vasc Anesth. 1999; 13: 12-7.
33. Reich DL, Bodian CA, Krol M, Kuroda M, Osinski T, Thys DM. Introperative hemodynamic predictors of mortality, stroke, and myocardial infarction after coronary artery bypass surgery. Anesth Analg. 1999; 89: 814-22.
34. Geraci JM, Johnson ML, Gordon HS, Peterson NJ, Laurie Shroyer A, Grover FL, Wray NP. Mortality after cardiac bypass surgery prediction from administrative versus clinical data. Med Care. 2005; 43: 149-58.
35. Coronary artery bypass surgery in New York state: 1989-1991. Albany, NY: New York State Department of Health; 1992.
36. Coronary artery bypass surgery in New York state: 1997-1999. Albany, NY: New York State Department of Health; 2002.
37. Hannan EL, Wu C, Ryan TJ, Edward Bennett, Culliford AT, Gold JP, Alan Hartman, Wayne Isom O, Jones RH, Barbara Ncneil, Rose EA, Subramanian VA. Do hospitals and surgerys with higher coronary artery bypass graft volumes still have lower risk-adjusted mortality rates? Circulation. 2003; 108: 795-801.
38. Nalysnyk L, Fahrbach K, Reynolds MW, Zhao SZ, Ross S. Adverse events in coronary artery bypass graft (CABG) trials: a systemic review and analysis. Heart. 2003; 89: 767-72.
39. Brezis M, Rosen S, Eptein FH. Acute renal failure due to ischemia (acute tubular necrosis). In Lazarus JM, Brenner BM eds. Acute renal failure, third edition. New York: Churchill Livingstone. 1993: 207-9.
40. Bahar I, Akgul A, Ozatik MA, Demirbag AE, Boran M, Tasdemir O. Acute renal failure following open heart surgery: risk factors and prognosis. Perfusion. 2005; 20: 317-22.
41. Carrascal Y, Guerrero AL, Maroto LC. Neurological complications after cardiopulmonary bypass: an update. Eur Neurol. 1999; 41: 128-34.
42. Craver JM, Puskas JD, Weintraub WW. 601 octogenarians undergoing cardiac surgery: outcomes and comparison with younger age groups. Ann Thorac Surg. 1999; 67: 1104-10.
43. Ganushchak YM, Fransen EJ, Cees Visser, de Jong DS, Maessen JG. Neurological complications after coronary artery bypass grafting related to the performance of cardiopulmonary bypass. Chest. 2004; 125: 2196-2205.
44. Hogue CW, Murphy SF, Schechtman KB, Dávila-Román VG. Risk factors for early or delayed stroke after cardiac surgery. Circulation. 1999; 100(6): 642-7.
45. Hogue CW, De Wet CJ, Schechtman KB, Dávila-Román VG. The importance of prior stroke for the adjusted risk of neurologic injury after cardiac surgery for women and men. Anesthesiology. 2003; 98: 823-9.
46. Hulzebos EHJ, Meeteren NLV, Bie RAD, Dagnelie PC, Helders PJM. Prediction of postoperative pulmonary complications on the basis of preoperative risk factors in patients who had undergone coronary artery bypass graft surgery. Phys Ther. 2003; 83: 8-16.
47. Hensley, Jr. FA, Martin DE, Gravlee GP. A practical apparoach to cardiac anesthesia. 3rd eds. 2003 by Lippincott Williams & Wilkins.
48. Christenson JT, Simonet F, Badel P, Schmuziger M. Evaluation of preoperative intra-aortic ballon pump support in high risk coronary patients. Eur J Cardio-thorac Surg. 1997; 11: 1097-1103.
49. Joseph D, Christophe D, Hugo E, Walter D, Stefan J. Survival of patients treated with intra-aortic ballon counterpulsation for cardiogenic shock in a tertiary cetre: variables correlated with death. Eur J Emer Med. 2003; 10: 213-8.
50. Geissler Hj, Sascha PH, Kuhn-Régnier F, Mehlhorn U, Sűdkamp M, Rainer de Vivie. Risk stratification in heart surgery/: comparison of six score systems. Eur J Cardio-Thorac Surg. 2000; 17: 400-6.
51. Parsonnet V, Dean D, Bernstein AD. A method of uniform stratification of risk for evaluating the results of surgery in acquired adult heart disease. Ciculation. 1989; 79(suppl I): 3-12.
52. Tuman KJ, McCarthy RJ, March RJ, Hassan N, Ivankovich AD. Morbidity and duration of ICU stayafter cardiac surgery. Chest. 1992; 102: 36-44.
53. Tu JV, Jaglal SB, Naylor D. Multicenter validation of a risk index for mortality, intensive care unit stay, and overall hospital length of stay after cardiac surgery. Circulation. 1995; 91: 677-84.
54. Nashef SAM, Roques F, Michel P, Gauducheau E, Lemeshow S, Salamon R. European system for cardiac operative risk evaluation. Eur J Cardio-Thorac Surg. 1999; 16: 9-13.
55. Nashef SAM, Roques F, Hammill BG, Peterson ED, Michel P, Grover FL, Wyse RKH, Bruce Ferguson T. Validation of European system for cardiac operative risk evaluation (EuroSCORE) in north American cardiac surgery. Eur J Cardio-Thorac Surg. 2002; 22: 101-5
56. Dupuis JY, Wang F, Nathan H, Lam M, Grimes S, Bourke M. The cardiac anesthesia risk evaluation score. Anesthesiology. 2001; 94: 194-204.
57. Quattara A, Niculescu M, Ghazouani S, Babolian A, Landi M, Lecomte P, Boccara G, Varnous S, Lep rince P, Riou B, Coriat P. Predictive performance and variability of the cardiac anesthesia risk evaluation score. Anesthesiology. 2004; 100: 1405-10.
58. Zaugg M, Tagliente T, Lucchinetti E, et al. Beneficial effects from b-adrenergic blockade in elderly patients undergoing noncardiac surgery. Anesthesiology. 1999; 91: 1674-86.
59. Warltier DC, b-adrenergic-blocking drugs, incredibly useful, incredibly underutilized. Anesthesiology. 1998; 88: 2-5.
描述 碩士
國立政治大學
風險管理與保險研究所
93932812
94
資料來源 http://thesis.lib.nccu.edu.tw/record/#G0093932812
資料類型 thesis
dc.contributor.advisor 蔡政憲zh_TW
dc.contributor.advisor Tsai, Chenghsienen_US
dc.contributor.author (作者) 程毅君zh_TW
dc.contributor.author (作者) Cherng, Yih-Giunen_US
dc.creator (作者) 程毅君zh_TW
dc.creator (作者) Cherng, Yih-Giunen_US
dc.date (日期) 2005en_US
dc.date.accessioned 2009-09-18-
dc.date.available 2009-09-18-
dc.date.issued (上傳時間) 2009-09-18-
dc.identifier (其他 識別碼) G0093932812en_US
dc.identifier.uri (URI) https://nccur.lib.nccu.edu.tw/handle/140.119/34131-
dc.description (描述) 碩士zh_TW
dc.description (描述) 國立政治大學zh_TW
dc.description (描述) 風險管理與保險研究所zh_TW
dc.description (描述) 93932812zh_TW
dc.description (描述) 94zh_TW
dc.description.abstract (摘要) 背景與目的:
每一項疾病都有其潛在的風險,但要有效的降低死亡率及併發症發生率,必須找出關鍵性指標加以改善或預防。我們以心臟冠狀動脈繞道手術之患者為例,希望藉由統計分析的方式,找出造成死亡以及術後併發症最相關的因素,目的不只在預測,而在於防範。

研究對象與方法:
在我們的實驗設計上,風險因子分布在手術前、手術中、以及手術後三個階段,對象是某醫學中心接受心臟冠狀動脈繞道手術的220例患者。分析採用迴歸統計建立模型,其中羅吉斯迴歸中的依變數為死亡率與罹病率,線性迴歸的依變數為加護病房留置天數以及總住院日數。ROC curve亦將被建立,以判斷模型是否能區別病患是否罹病或死亡。所得資料亦計算EuroScore及其ROC曲線面積,並與歷史資料做比較。

結果:
所建立的死亡估計模型的有兩個,預測值都在97%以上,ROC曲線面積亦都超過0.96;併發症估計模型由六個變數所構成,預測率及ROC曲線面積分別為94%和0.984。加護病房留置天數及住院天數估計模型分別由八個及十三個因子來解釋,調整後的R square分別為0.527及0.6。EuroScore對死亡與併發症的預測率,分別為93.7%和82%,ROC曲線面積分別是0.864和0.797,均高於歷史文獻記錄,未來應該廣泛應用。

結論與建議:
經由適當的風險分級和危險因子分析,我們可以找出風險高低的標準和依據,了解影響死亡率與罹病率的關鍵因子是什麼,儘可能的做事前的防範與處置,希望能夠改善結果並提高手術的存活率。
EuroScore是個值得採用的預測工具,可以廣泛應用在死亡率與併發症發生率的估計,但是必須搭配風險因子的改善,才能發揮實際的功效。我們認為,體外循環時間與再次手術是最具有空間來降低死亡率與罹病率的兩個要素,有效率的控制時間、改善造成再手術的前因後果,除了死亡率與併發症發生率的下降外,還可以及早脫離對加護病房照顧的需求並減少留置的天數。
zh_TW
dc.description.tableofcontents 謝辭 2
論文摘要 3~4
論文目錄 5~6
表格目錄 7~8
圖形目錄 8
一、緒論
1-1 研究背景與動機 9~11
1-2 研究目的 11
1-3 研究限制 11
二、文獻回顧
2-1 風險因子-自變數或獨立變數的探討 12~20
2-2 依變數文獻探討分析 21~25
2-3 風險評估預測系統 26~33
三、研究對象及方法
3-1 風險因子的選取 34~36
3-2 研究對象 37
3-3 統計與資料分析方法 37~38
四、研究結果
4-1 基本資料 39~41
4-2 死亡及併發症估計模型
4-2-1 死亡估計模型 42~48
4-2-2 併發症估計模型 49~51
4-3 加護病房留置天數及住院天數估計模型
4-3-1 加護病房留置天數估計模型 52~53
4-3-2 住院天數估計模型 54~56
4-4 EuroScore分析
4-4-1 罹病率 57~58
4-4-2 死亡率 59~60
4-5 變數整理 60~61
五、討論與建議
5-1 死亡模型 62~65
5-2 併發症模型 65
5-3 加護病房留置天數及總住院天數模型 66~67
5-4 EuroScore的應用 67~68
5-5 建議 68~69
六、參考文獻 70~75
zh_TW
dc.format.extent 49709 bytes-
dc.format.extent 72378 bytes-
dc.format.extent 77544 bytes-
dc.format.extent 80970 bytes-
dc.format.extent 121114 bytes-
dc.format.extent 262029 bytes-
dc.format.extent 127874 bytes-
dc.format.extent 277736 bytes-
dc.format.extent 141499 bytes-
dc.format.extent 109090 bytes-
dc.format.mimetype application/pdf-
dc.format.mimetype application/pdf-
dc.format.mimetype application/pdf-
dc.format.mimetype application/pdf-
dc.format.mimetype application/pdf-
dc.format.mimetype application/pdf-
dc.format.mimetype application/pdf-
dc.format.mimetype application/pdf-
dc.format.mimetype application/pdf-
dc.format.mimetype application/pdf-
dc.language.iso en_US-
dc.source.uri (資料來源) http://thesis.lib.nccu.edu.tw/record/#G0093932812en_US
dc.subject (關鍵詞) 冠狀動脈繞道手術zh_TW
dc.subject (關鍵詞) 體外循環zh_TW
dc.subject (關鍵詞) 罹病率zh_TW
dc.subject (關鍵詞) 死亡率zh_TW
dc.subject (關鍵詞) Coronary artery bypass grafting surgeryen_US
dc.subject (關鍵詞) Cardiopulmonary bypassen_US
dc.subject (關鍵詞) Morbidity rateen_US
dc.subject (關鍵詞) Mortality rateen_US
dc.subject (關鍵詞) EuroScoreen_US
dc.title (題名) 以疾病為導向之醫療風險管理-以心臟冠狀動脈繞道手術為例zh_TW
dc.title (題名) Disease-oriented control of medical risks- analyzed with coronary artery bypass grafting surgeryen_US
dc.type (資料類型) thesisen
dc.relation.reference (參考文獻) 1. Prabhakar G, Haan CK, Peterson ED, Coombs LP, Cruzzavala JL, Murray GF. The risks of moderate and extreme obesity for coronary artery grafting outcomes: a study from the society of Thoracic Surgeon"s database. Ann Thorac Surg. 2002; 74: 1125-31.zh_TW
dc.relation.reference (參考文獻) 2. Ivert T, Sandberg E, Hammar N. Obesity doesn"t increase the risks of coronary surgery: results from a study of 7,248 patients who underwent the surgery. Lakartidningen. 2000; 97: 972-4.zh_TW
dc.relation.reference (參考文獻) 3. Reeves BC, Ascione R, Chamberlain MH, Angelini GD. Effect of body mass index on early outcome in patients undergoing coronary artery bypass surgery. J Am Coll Cardiol. 2003; 42: 668-76.zh_TW
dc.relation.reference (參考文獻) 4. Ruyun Jin, Grunkemeier GL, Furnary AP, Handy Jr JR. Is obesity a risk factor for mortality in coronary artery bypass surgery? Circulation. 2005; 111: 3359-65.zh_TW
dc.relation.reference (參考文獻) 5. Mohan R, Amsel BJ, Walter PJ. Coronary artery bypass grafting in the elderly: a review of studies on patients older than 64, 69 or 74 years. Cardiology. 1992; 80: 21-25.zh_TW
dc.relation.reference (參考文獻) 6. Peterson ED, Jollis JG, Bebchuk JD. Changes in mortality after myocardial revascularization in the elderly: the national medical experience. Ann Intern Med. 1994; 121: 919-27.zh_TW
dc.relation.reference (參考文獻) 7. Graham MM, Ghali WA, Faris PD, Galbraith PD, Norris CM, Knudtson ML. Survival after coronary revascularization in the elderly. Circulation. 2002; 105: 2378-84.zh_TW
dc.relation.reference (參考文獻) 8. Zaidi AM, Fitzpatrick AP, Keenan DJM, Odom NJ, Grotte GJ. Good outcome from cardiac surgery in the over 70s. Heart. 1999; 82: 134-7.zh_TW
dc.relation.reference (參考文獻) 9. Smith KM, Lamy A, Arthur HM, Gafni A, Kent R. Outcomes and costs of coronary artery bypass grafting: comparison between octogenarians and septuagenarians at a tertiary care center. Can Med Asso J. 2001; 165(6): 759-64.zh_TW
dc.relation.reference (參考文獻) 10. Edwards FH, Carey JS, Grover FL, Bero JW, Hartz RS. Impact of gender on coronary bypass operative mortality. Ann Thorac Surg. 1998; 66: 125-31.zh_TW
dc.relation.reference (參考文獻) 11. Hogue CW, Thoralf Sundt, Benico Barzilai, Schecthman KB, Dávila-Román VG. Cardiac and neurologic complications identify risks for mortality for both men and women undergoing coronary artery bypass graft surgery. Anesthesiology. 2001; 95: 1074-8.zh_TW
dc.relation.reference (參考文獻) 12. Blankstein R, Ward RP, Arnsdrof M, Jones B, Lou YB, Pine M. Female gender is an independent predictor of operative mortality after coronary artery bypass graft surgery. Circulation. 2005; 112(suppl I): 323-7.zh_TW
dc.relation.reference (參考文獻) 13. Psaty BM, Heckbert SR, Koepsell TD. The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA. 1995; 274: 620-5.zh_TW
dc.relation.reference (參考文獻) 14. Fuberg CD, Psaty BM, Meyer JV. Nifedipine: dose-related increase in mortality in patients with coronary artery disease. Circulation. 1995; 92: 1326-31.zh_TW
dc.relation.reference (參考文獻) 15. Weightman WM, Gibbs NM, Sheminant MR, Whitford EG, Mahon BD, Newman MAJ. Drug therapy before coronary artery surgery: nitrates are independent predictors of mortality and b-adrenergic blockers predict survival. Anesth Analg. 1999; 88: 286-91.zh_TW
dc.relation.reference (參考文獻) 16. Ferguson TB, Coombs LP, Peterson ED. Preoperative use b-blockers and mortality and morbidity following CABG surgery in North America. JAMA. 2002; 287: 2221-7.zh_TW
dc.relation.reference (參考文獻) 17. ten Broecke PWC, De Hert SG, Mertens E, Adriaensen HF. Effect of preoperative b-blockade on perioperative mortality in coronary surgery. BJA. 2003; 90(1): 27-31.zh_TW
dc.relation.reference (參考文獻) 18. DeFrances CJ, Hall MJ. 2002 National hospital discharge survey. Adv Data. 2004: 1-29.zh_TW
dc.relation.reference (參考文獻) 19. Gandhi GY, Nuttall GA, Abel MD, Mullany CJ, Schaff HV, Williams BA, Schrader LM, Rizza RA, Molly McMahon M. Intraoperative hyperglycemia and perioperative outcomes in cardiac surgery patients. Mayo Clin Proc. 2005; 80(7): 862-6.zh_TW
dc.relation.reference (參考文獻) 20. Morricone L, Rannucci M, Cazzaniga SDA, Isgró G, Enrini R, Caviezel F. Diabetes and complications after cardiac surgery: comparison with a non-diabetic population. Acta Diabetol. 1999; 36: 77-84.zh_TW
dc.relation.reference (參考文獻) 21. Braith RW, Welsch MA, Feigenbaum MS. Neuroendocrine activation in the heart failure is modified by endurance exercise training. J Am Coll Cardiol. 1999; 34: 1170-5.zh_TW
dc.relation.reference (參考文獻) 22. Dimopoulou I, Daganou M, Tsintzas OK. Effects of severity of long-standing congestive heart failure on pulmonary function. Respir Med. 1998; 92: 1321-25.zh_TW
dc.relation.reference (參考文獻) 23. Johnson BD, Beck KC, Olson LJ, O"Malley KA, Allison TG, Squires RW, Gau GT. Pulmonary function in patients with reduced left ventricular function. Influence of smoking and cardiac surgery. Chest. 2001; 120: 1869-76.zh_TW
dc.relation.reference (參考文獻) 24. Mazzarella V, Gallucci MT, Tozzo C. Renal function in patients undergoing cardiopulmonary bypass operations. J Thorac Cardiovasc Surg. 1992; 104: 1625-7.zh_TW
dc.relation.reference (參考文獻) 25. Mangano CM, Diamondstone LS, Ramsay JG. Renal dysfunction after myocardial revascularization: risk factors, adverse outcomes, and hospital resource utilization. Ann Intern Med. 1998; 128: 194-203.zh_TW
dc.relation.reference (參考文獻) 26. Ryckwaert F, Boccara G, Frappier JM, Colson PH. Incidence, risk factors, and prognosis of a moderate increase in plasma creatinine early after cardiac surgery. Crit Care Med. 2002; 30: 1495-8.zh_TW
dc.relation.reference (參考文獻) 27. Bechtel M, Fischlein T, Krabatsch T, Nägele H, Osswald B, Schönburg M, Scholz F, Stamm C, Stripling J, Sievers H, Bartels C. An analysis of the risk factors for perioperative mortality in patients with end-stage renal failure undergoing cardiac surgery: a multicenter study. Thorac ardiovasc Surg. 2005; 53:zh_TW
dc.relation.reference (參考文獻) 28. Holmes JH, Connolly NC, Hill ME, Guyton SW, Hall RA. Magnitude of the inflammatory response to cardiopulmonary bypass and its relation to adverse clinical outcomes. Inflamm Res. 2002; 51: 579-86.zh_TW
dc.relation.reference (參考文獻) 29. Miller BE, Guzzetta NA, Tosone SR, Levy JH. Rapid evaluation of coagulopathies after cardiopulmonary bypass in children using modified thromboelastography. Anesth Analg. 2000; 90(6): 1324-30.zh_TW
dc.relation.reference (參考文獻) 30. Habib RH, Anoar Zacharias, Schwann TA, Riordan CJ, Milo Engoren, Durham SJ, Aamir Shah. Role of hemodilutional anemia and transfusion during cardiopulmonary bypass in renal injury after coronary revascularization: implications on operative outcome. Crit Care Med. 2005; 33: 1749-56.zh_TW
dc.relation.reference (參考文獻) 31. McSweeney ME, Susan Garwood, Jack Levin, marino MR, Wang SX, David kardatzke, mangano DT, Wolman RL. Adverse gastrointestinal complications after cardiopulmonary bypass: can outcome be predicted from preoperative risk factors? Anesth Analg. 2004; 98: 1610-7.zh_TW
dc.relation.reference (參考文獻) 32. Murkin JM. Etiology and incidence of brain dysfunction after cardiac surgery. J Cardiothorac Vasc Anesth. 1999; 13: 12-7.zh_TW
dc.relation.reference (參考文獻) 33. Reich DL, Bodian CA, Krol M, Kuroda M, Osinski T, Thys DM. Introperative hemodynamic predictors of mortality, stroke, and myocardial infarction after coronary artery bypass surgery. Anesth Analg. 1999; 89: 814-22.zh_TW
dc.relation.reference (參考文獻) 34. Geraci JM, Johnson ML, Gordon HS, Peterson NJ, Laurie Shroyer A, Grover FL, Wray NP. Mortality after cardiac bypass surgery prediction from administrative versus clinical data. Med Care. 2005; 43: 149-58.zh_TW
dc.relation.reference (參考文獻) 35. Coronary artery bypass surgery in New York state: 1989-1991. Albany, NY: New York State Department of Health; 1992.zh_TW
dc.relation.reference (參考文獻) 36. Coronary artery bypass surgery in New York state: 1997-1999. Albany, NY: New York State Department of Health; 2002.zh_TW
dc.relation.reference (參考文獻) 37. Hannan EL, Wu C, Ryan TJ, Edward Bennett, Culliford AT, Gold JP, Alan Hartman, Wayne Isom O, Jones RH, Barbara Ncneil, Rose EA, Subramanian VA. Do hospitals and surgerys with higher coronary artery bypass graft volumes still have lower risk-adjusted mortality rates? Circulation. 2003; 108: 795-801.zh_TW
dc.relation.reference (參考文獻) 38. Nalysnyk L, Fahrbach K, Reynolds MW, Zhao SZ, Ross S. Adverse events in coronary artery bypass graft (CABG) trials: a systemic review and analysis. Heart. 2003; 89: 767-72.zh_TW
dc.relation.reference (參考文獻) 39. Brezis M, Rosen S, Eptein FH. Acute renal failure due to ischemia (acute tubular necrosis). In Lazarus JM, Brenner BM eds. Acute renal failure, third edition. New York: Churchill Livingstone. 1993: 207-9.zh_TW
dc.relation.reference (參考文獻) 40. Bahar I, Akgul A, Ozatik MA, Demirbag AE, Boran M, Tasdemir O. Acute renal failure following open heart surgery: risk factors and prognosis. Perfusion. 2005; 20: 317-22.zh_TW
dc.relation.reference (參考文獻) 41. Carrascal Y, Guerrero AL, Maroto LC. Neurological complications after cardiopulmonary bypass: an update. Eur Neurol. 1999; 41: 128-34.zh_TW
dc.relation.reference (參考文獻) 42. Craver JM, Puskas JD, Weintraub WW. 601 octogenarians undergoing cardiac surgery: outcomes and comparison with younger age groups. Ann Thorac Surg. 1999; 67: 1104-10.zh_TW
dc.relation.reference (參考文獻) 43. Ganushchak YM, Fransen EJ, Cees Visser, de Jong DS, Maessen JG. Neurological complications after coronary artery bypass grafting related to the performance of cardiopulmonary bypass. Chest. 2004; 125: 2196-2205.zh_TW
dc.relation.reference (參考文獻) 44. Hogue CW, Murphy SF, Schechtman KB, Dávila-Román VG. Risk factors for early or delayed stroke after cardiac surgery. Circulation. 1999; 100(6): 642-7.zh_TW
dc.relation.reference (參考文獻) 45. Hogue CW, De Wet CJ, Schechtman KB, Dávila-Román VG. The importance of prior stroke for the adjusted risk of neurologic injury after cardiac surgery for women and men. Anesthesiology. 2003; 98: 823-9.zh_TW
dc.relation.reference (參考文獻) 46. Hulzebos EHJ, Meeteren NLV, Bie RAD, Dagnelie PC, Helders PJM. Prediction of postoperative pulmonary complications on the basis of preoperative risk factors in patients who had undergone coronary artery bypass graft surgery. Phys Ther. 2003; 83: 8-16.zh_TW
dc.relation.reference (參考文獻) 47. Hensley, Jr. FA, Martin DE, Gravlee GP. A practical apparoach to cardiac anesthesia. 3rd eds. 2003 by Lippincott Williams & Wilkins.zh_TW
dc.relation.reference (參考文獻) 48. Christenson JT, Simonet F, Badel P, Schmuziger M. Evaluation of preoperative intra-aortic ballon pump support in high risk coronary patients. Eur J Cardio-thorac Surg. 1997; 11: 1097-1103.zh_TW
dc.relation.reference (參考文獻) 49. Joseph D, Christophe D, Hugo E, Walter D, Stefan J. Survival of patients treated with intra-aortic ballon counterpulsation for cardiogenic shock in a tertiary cetre: variables correlated with death. Eur J Emer Med. 2003; 10: 213-8.zh_TW
dc.relation.reference (參考文獻) 50. Geissler Hj, Sascha PH, Kuhn-Régnier F, Mehlhorn U, Sűdkamp M, Rainer de Vivie. Risk stratification in heart surgery/: comparison of six score systems. Eur J Cardio-Thorac Surg. 2000; 17: 400-6.zh_TW
dc.relation.reference (參考文獻) 51. Parsonnet V, Dean D, Bernstein AD. A method of uniform stratification of risk for evaluating the results of surgery in acquired adult heart disease. Ciculation. 1989; 79(suppl I): 3-12.zh_TW
dc.relation.reference (參考文獻) 52. Tuman KJ, McCarthy RJ, March RJ, Hassan N, Ivankovich AD. Morbidity and duration of ICU stayafter cardiac surgery. Chest. 1992; 102: 36-44.zh_TW
dc.relation.reference (參考文獻) 53. Tu JV, Jaglal SB, Naylor D. Multicenter validation of a risk index for mortality, intensive care unit stay, and overall hospital length of stay after cardiac surgery. Circulation. 1995; 91: 677-84.zh_TW
dc.relation.reference (參考文獻) 54. Nashef SAM, Roques F, Michel P, Gauducheau E, Lemeshow S, Salamon R. European system for cardiac operative risk evaluation. Eur J Cardio-Thorac Surg. 1999; 16: 9-13.zh_TW
dc.relation.reference (參考文獻) 55. Nashef SAM, Roques F, Hammill BG, Peterson ED, Michel P, Grover FL, Wyse RKH, Bruce Ferguson T. Validation of European system for cardiac operative risk evaluation (EuroSCORE) in north American cardiac surgery. Eur J Cardio-Thorac Surg. 2002; 22: 101-5zh_TW
dc.relation.reference (參考文獻) 56. Dupuis JY, Wang F, Nathan H, Lam M, Grimes S, Bourke M. The cardiac anesthesia risk evaluation score. Anesthesiology. 2001; 94: 194-204.zh_TW
dc.relation.reference (參考文獻) 57. Quattara A, Niculescu M, Ghazouani S, Babolian A, Landi M, Lecomte P, Boccara G, Varnous S, Lep rince P, Riou B, Coriat P. Predictive performance and variability of the cardiac anesthesia risk evaluation score. Anesthesiology. 2004; 100: 1405-10.zh_TW
dc.relation.reference (參考文獻) 58. Zaugg M, Tagliente T, Lucchinetti E, et al. Beneficial effects from b-adrenergic blockade in elderly patients undergoing noncardiac surgery. Anesthesiology. 1999; 91: 1674-86.zh_TW
dc.relation.reference (參考文獻) 59. Warltier DC, b-adrenergic-blocking drugs, incredibly useful, incredibly underutilized. Anesthesiology. 1998; 88: 2-5.zh_TW