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題名 利用神經心理作業初探臺灣地區海洛因戒治者之認知功能研究
The cognitive function research of the abstinent heroin users in Taiwan by using neuropsychological task
作者 黃華妮
貢獻者 許文耀
黃華妮
關鍵詞 海洛因
注意力偏誤
執行功能
成癮嚴重度
日期 2009
上傳時間 11-十月-2011 16:55:33 (UTC+8)
摘要 本研究主要是利用國內的海洛因戒治者,透過神經心理作業探討長期使用海洛因對於個體在注意力偏誤、轉換彈性和抑制能力上的影響。
根據Robinson和Berridge(1993, 2003)的理論認為成癮嚴重度越高,藥物相關線索的注意力偏誤越明顯;然而,根據Di Chiara(2000)提出關於整合誘因和習慣的觀點,認為成癮的注意力偏誤和趨向行為會受到不同的成癮嚴重度(輕度或重度成癮)或成癮階段(早期或習慣化後期)而有不同的結果,另外,以往的執行功能損害也支持Robinson和Berridge(1993, 2003)成癮嚴重度的觀點,因此本研究企圖同時檢驗上述兩者觀點。

本研究篩選111名台中戒治所和看守所的海洛因戒治者,分別根據不同的成癮嚴重程度分類方式分組(依賴嚴重度量表、不同頻率、施用方式),加上29名健康對照組,共140名受試均需完成自陳氏量表、紙筆測驗和各項神經心理測驗(Stroop叫色作業、威斯康辛卡片分類測驗、Go/No Go作業)。

研究結果指出海洛因戒治者相較對照組確實在注意力偏誤、認知彈性轉換、以及反應抑制能力有損害的趨勢,而且似乎較符合Di Chiara(2000)提出整合誘因和習慣的觀點,認為成癮者的認知功能會與成癮嚴重度成負向關係。
參考文獻 中文部分
行政院衛生署管制藥品管理局(2009)。台灣地區精神醫療院所通報海洛因藥物濫用個案件數。臺北市,行政院衛生署。
法務部(1999):毒品危害防制條例參考資料彙編。臺北市,法務部。
林柏君(2005)。影響毒品犯戒治成效相關因素之研究。國立中正大學犯罪防治研究所碩士論文。
俞筱鈞(1994)。瑞文氏標準圖形推理測驗指導手冊。台北市:中國行為科學社。
黃秀霜(2001)。中文年級認字量表:指導手冊。台北市:心理出版社。
英文部分
Bradley, B., Field, M., Mogg, K., & DeHouwer, J. (2004). Attentional and evaluative biases for smoking cues in nicotine dependence: component processes of biases in visual orienting. Behavior Pharmacology, 15, 29–36.
Bruce, G., & Jones, B. T. (2006). Methods that measure attentional bias. Handbook on implicit cognition and addiction. Thousand Oaks, CA: SAGE, 135−149.
Bradley, B. P., Mogg, K., Wright, T., & Field, M. (2003). Attentional bias in drug dependence: vigilance for cigarette-related cues in smokers. Psychological Addict Behaviors, 17, 66–72.
Bechara, A., Noel, X., & Crone, E. A. (2006). Loss of willpower: abnormal neural mechanisms of impulse control and decision making in addiction. Handbook of implicit cognition and addiction. Thousand Oaks CA: SAGE, 215–32.
Bearre, L., Sturt, P., Bruce, G., & Jones, B. T. (2007). Heroin-related attentional bias and monthly frequency of heroin use are positively associated in attenders of a harm reduction service. Addictive Behaviors, 32, 784–792.
Chen, C. H., Chen, H., Lin, T. Y., Chou, H. H., Lai, T. J., Ferri, C. P., Gossop. M. (2008). Severity of heroin dependence in Taiwan: Reliability and validity of the Chinese version of the Severity of Dependence Scale (SDS [Ch]). Addictive Behaviors, 33, 1590–1593.
Chen, Y. J., Ho, M. Y., Chen, K. J., Hsu, C. F., & Ryu, S. J. (2009). Estimation of premorbid general fluid intelligenceusing traditional Chinese reading performance in Taiwanese samples. Psychiatry and Clinical Neurosciences, 63, 500–507
Cox,W. M., & Klinger, E. (1988). A motivational model of alcohol use. Journal Abnormal Psychology, 97, 168–180.
Cox, W. M., Yeates, G. N., & Regan, C. M. (1999). Effects of alcohol cues on cognitive processing in heavy and light drinkers. Drug Alcohol Depend, 55, 85–89.
Cox, W. M., Fadardi, J., & Pothos, E. M. (2006). The Addiction-Stroop Test: Theoretical Considerations and Procedural Recommendations. Psychological Bulletin, 132, 443−476.
Clark, L., Robbins, T. W., Ersche, K. D., & Sahakian, B. J. (2006). Reflection impulsivity in current and former substance users. Biological Psychiatry, 60, 515–522.
Di Chiara, G. (2000). Role of dopamine in the behavioural actions of nicotine related to addiction. European Journal of Pharmacology, 393, 295−314.
Davis, P. E., Liddard, H., & McMillan, T. M. (2002). Neuropsychological
deficits and opiate abuse. Drug Alcohol Depend, 67, 105–108.
Darke, S., Sims, J., McDonald, S., & Wickes, W. (2000). Cognitive impairment among methadone maintenance patients. Addiction, 95(5), 687-695
Field, M. (2005). Cannabis dependence and attentional bias for cannabis-related words. Behavior. Pharmacology, 16, 473–476.
Field, M., Mogg, K., Zetteler, J., & Bradley, B. P. (2004). Attentional biases for alcohol cues in heavy and light social drinkers: the roles of initial orienting and maintained attention. Psychopharmacology (Berl.), 176, 88–93.
Field, M., & Eastwood, B. (2005). Experimental manipulation of attentional bias increases the motivation to drink alcohol. Psychopharmacology (Berl.), 183, 350–357.
Field, M., & Cox, W. M. (2008). Attentional bias in addictive behaviors: A review of its development, causes, and consequences. Drug and Alcohol Dependence, 97, 1–20
Fu L. P., Bi, G. H., Zou, Z. T., Wang, W., Ye, E. M., Ma, L., Fan, M., & Yang, Z. (2008). Impaired response inhibition function in abstinent heroin dependents: An fMRI study. Neuroscience Letters, 438, 322–326
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描述 碩士
國立政治大學
心理學研究所
95752015
98
資料來源 http://thesis.lib.nccu.edu.tw/record/#G0095752015
資料類型 thesis
dc.contributor.advisor 許文耀zh_TW
dc.contributor.author (作者) 黃華妮zh_TW
dc.creator (作者) 黃華妮zh_TW
dc.date (日期) 2009en_US
dc.date.accessioned 11-十月-2011 16:55:33 (UTC+8)-
dc.date.available 11-十月-2011 16:55:33 (UTC+8)-
dc.date.issued (上傳時間) 11-十月-2011 16:55:33 (UTC+8)-
dc.identifier (其他 識別碼) G0095752015en_US
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/51582-
dc.description (描述) 碩士zh_TW
dc.description (描述) 國立政治大學zh_TW
dc.description (描述) 心理學研究所zh_TW
dc.description (描述) 95752015zh_TW
dc.description (描述) 98zh_TW
dc.description.abstract (摘要) 本研究主要是利用國內的海洛因戒治者,透過神經心理作業探討長期使用海洛因對於個體在注意力偏誤、轉換彈性和抑制能力上的影響。
根據Robinson和Berridge(1993, 2003)的理論認為成癮嚴重度越高,藥物相關線索的注意力偏誤越明顯;然而,根據Di Chiara(2000)提出關於整合誘因和習慣的觀點,認為成癮的注意力偏誤和趨向行為會受到不同的成癮嚴重度(輕度或重度成癮)或成癮階段(早期或習慣化後期)而有不同的結果,另外,以往的執行功能損害也支持Robinson和Berridge(1993, 2003)成癮嚴重度的觀點,因此本研究企圖同時檢驗上述兩者觀點。

本研究篩選111名台中戒治所和看守所的海洛因戒治者,分別根據不同的成癮嚴重程度分類方式分組(依賴嚴重度量表、不同頻率、施用方式),加上29名健康對照組,共140名受試均需完成自陳氏量表、紙筆測驗和各項神經心理測驗(Stroop叫色作業、威斯康辛卡片分類測驗、Go/No Go作業)。

研究結果指出海洛因戒治者相較對照組確實在注意力偏誤、認知彈性轉換、以及反應抑制能力有損害的趨勢,而且似乎較符合Di Chiara(2000)提出整合誘因和習慣的觀點,認為成癮者的認知功能會與成癮嚴重度成負向關係。
zh_TW
dc.description.tableofcontents 第一章 緒論 1
第一節 研究背景與動機 1
第二章 文獻探討 5
第一節 海洛因成癮者的認知功能 5
第二節 注意力偏誤 14
第三節 海洛因成癮者的執行功能問題 20
第四節 研究目的與架構 30
第五節 研究假設 32
第四章 研究結果 47
第一節 受試者的基本資料描述 47
第二節 海洛因戒治者與控制組在神經心理作業表現上的比較 62
第三節 成癮嚴重度與神經心理作業表現的相關 79
第五章 綜合討論 82
第一節 國內海洛因戒治者的神經心理作業表現 82
第二節 成癮嚴重度與神經心理作業表現的相關 85
第三節 研究限制 88
第四節 未來研究方向 92
參考文獻 93
附錄一 受試者研究參與同意書 104
附錄二 海洛因戒治者之基本資料問卷以及中文版依賴嚴重度量表 106
附錄三 對照組之基本資料問卷 108
附錄四 各項神經心理測驗之指導語 109
附錄五 Go/ No Go圖片刺激材料之選取 111
zh_TW
dc.language.iso en_US-
dc.source.uri (資料來源) http://thesis.lib.nccu.edu.tw/record/#G0095752015en_US
dc.subject (關鍵詞) 海洛因zh_TW
dc.subject (關鍵詞) 注意力偏誤zh_TW
dc.subject (關鍵詞) 執行功能zh_TW
dc.subject (關鍵詞) 成癮嚴重度zh_TW
dc.title (題名) 利用神經心理作業初探臺灣地區海洛因戒治者之認知功能研究zh_TW
dc.title (題名) The cognitive function research of the abstinent heroin users in Taiwan by using neuropsychological tasken_US
dc.type (資料類型) thesisen
dc.relation.reference (參考文獻) 中文部分zh_TW
dc.relation.reference (參考文獻) 行政院衛生署管制藥品管理局(2009)。台灣地區精神醫療院所通報海洛因藥物濫用個案件數。臺北市,行政院衛生署。zh_TW
dc.relation.reference (參考文獻) 法務部(1999):毒品危害防制條例參考資料彙編。臺北市,法務部。zh_TW
dc.relation.reference (參考文獻) 林柏君(2005)。影響毒品犯戒治成效相關因素之研究。國立中正大學犯罪防治研究所碩士論文。zh_TW
dc.relation.reference (參考文獻) 俞筱鈞(1994)。瑞文氏標準圖形推理測驗指導手冊。台北市:中國行為科學社。zh_TW
dc.relation.reference (參考文獻) 黃秀霜(2001)。中文年級認字量表:指導手冊。台北市:心理出版社。zh_TW
dc.relation.reference (參考文獻) 英文部分zh_TW
dc.relation.reference (參考文獻) Bradley, B., Field, M., Mogg, K., & DeHouwer, J. (2004). Attentional and evaluative biases for smoking cues in nicotine dependence: component processes of biases in visual orienting. Behavior Pharmacology, 15, 29–36.zh_TW
dc.relation.reference (參考文獻) Bruce, G., & Jones, B. T. (2006). Methods that measure attentional bias. Handbook on implicit cognition and addiction. Thousand Oaks, CA: SAGE, 135−149.zh_TW
dc.relation.reference (參考文獻) Bradley, B. P., Mogg, K., Wright, T., & Field, M. (2003). Attentional bias in drug dependence: vigilance for cigarette-related cues in smokers. Psychological Addict Behaviors, 17, 66–72.zh_TW
dc.relation.reference (參考文獻) Bechara, A., Noel, X., & Crone, E. A. (2006). Loss of willpower: abnormal neural mechanisms of impulse control and decision making in addiction. Handbook of implicit cognition and addiction. Thousand Oaks CA: SAGE, 215–32.zh_TW
dc.relation.reference (參考文獻) Bearre, L., Sturt, P., Bruce, G., & Jones, B. T. (2007). Heroin-related attentional bias and monthly frequency of heroin use are positively associated in attenders of a harm reduction service. Addictive Behaviors, 32, 784–792.zh_TW
dc.relation.reference (參考文獻) Chen, C. H., Chen, H., Lin, T. Y., Chou, H. H., Lai, T. J., Ferri, C. P., Gossop. M. (2008). Severity of heroin dependence in Taiwan: Reliability and validity of the Chinese version of the Severity of Dependence Scale (SDS [Ch]). Addictive Behaviors, 33, 1590–1593.zh_TW
dc.relation.reference (參考文獻) Chen, Y. J., Ho, M. Y., Chen, K. J., Hsu, C. F., & Ryu, S. J. (2009). Estimation of premorbid general fluid intelligenceusing traditional Chinese reading performance in Taiwanese samples. Psychiatry and Clinical Neurosciences, 63, 500–507zh_TW
dc.relation.reference (參考文獻) Cox,W. M., & Klinger, E. (1988). A motivational model of alcohol use. Journal Abnormal Psychology, 97, 168–180.zh_TW
dc.relation.reference (參考文獻) Cox, W. M., Yeates, G. N., & Regan, C. M. (1999). Effects of alcohol cues on cognitive processing in heavy and light drinkers. Drug Alcohol Depend, 55, 85–89.zh_TW
dc.relation.reference (參考文獻) Cox, W. M., Fadardi, J., & Pothos, E. M. (2006). The Addiction-Stroop Test: Theoretical Considerations and Procedural Recommendations. Psychological Bulletin, 132, 443−476.zh_TW
dc.relation.reference (參考文獻) Clark, L., Robbins, T. W., Ersche, K. D., & Sahakian, B. J. (2006). Reflection impulsivity in current and former substance users. Biological Psychiatry, 60, 515–522.zh_TW
dc.relation.reference (參考文獻) Di Chiara, G. (2000). Role of dopamine in the behavioural actions of nicotine related to addiction. European Journal of Pharmacology, 393, 295−314.zh_TW
dc.relation.reference (參考文獻) Davis, P. E., Liddard, H., & McMillan, T. M. (2002). Neuropsychologicalzh_TW
dc.relation.reference (參考文獻) deficits and opiate abuse. Drug Alcohol Depend, 67, 105–108.zh_TW
dc.relation.reference (參考文獻) Darke, S., Sims, J., McDonald, S., & Wickes, W. (2000). Cognitive impairment among methadone maintenance patients. Addiction, 95(5), 687-695zh_TW
dc.relation.reference (參考文獻) Field, M. (2005). Cannabis dependence and attentional bias for cannabis-related words. Behavior. Pharmacology, 16, 473–476.zh_TW
dc.relation.reference (參考文獻) Field, M., Mogg, K., Zetteler, J., & Bradley, B. P. (2004). Attentional biases for alcohol cues in heavy and light social drinkers: the roles of initial orienting and maintained attention. Psychopharmacology (Berl.), 176, 88–93.zh_TW
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