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題名 Two-stage analysis for gene-environment interaction utilizing both case-only and family-based analysis
作者 程毅豪;林惠文;劉惠美
Chen, Yi-Hau;Lin, Hui-Wen;Liu, Huimei
貢獻者 政大統計系
關鍵詞 case-parent studies;case-sibling studies;gene-environment independence;parental missingness
日期 2009-02
上傳時間 12-十二月-2013 18:09:16 (UTC+8)
摘要 The case-only study and family-based study are two popular study designs for detecting gene-environment interactions. It is well known that the case-only analysis is efficient, but its validity relies crucially on the assumption of gene-environment independence in the study population. In contrast, the family-based analysis is robust to the violation of such an assumption, but is less efficient. We propose a two-stage study design for detecting gene-environment interactions, where a case-only study is performed at the first stage, and a case-parent/case-sibling study is performed at the second stage on a random subsample of the first-stage case sample as well as their parents/unaffected siblings. Statistical inference procedures are developed for the proposed two-stage study designs, which not only preserve the robustness property of the family-based analysis, but also utilize information from the case-only analysis to enhance estimation efficiency and testing power. Simulation results reveal both the robustness and efficiency of the proposed strategies. Genet. Epidemiol. 2008. © 2008 Wiley-Liss, Inc.
關聯 Genet Epidemiol, 33(2), 95-104
資料類型 article
DOI http://dx.doi.org/10.1002/gepi.20357
dc.contributor 政大統計系en_US
dc.creator (作者) 程毅豪;林惠文;劉惠美zh_TW
dc.creator (作者) Chen, Yi-Hau;Lin, Hui-Wen;Liu, Huimeien_US
dc.date (日期) 2009-02en_US
dc.date.accessioned 12-十二月-2013 18:09:16 (UTC+8)-
dc.date.available 12-十二月-2013 18:09:16 (UTC+8)-
dc.date.issued (上傳時間) 12-十二月-2013 18:09:16 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/62447-
dc.description.abstract (摘要) The case-only study and family-based study are two popular study designs for detecting gene-environment interactions. It is well known that the case-only analysis is efficient, but its validity relies crucially on the assumption of gene-environment independence in the study population. In contrast, the family-based analysis is robust to the violation of such an assumption, but is less efficient. We propose a two-stage study design for detecting gene-environment interactions, where a case-only study is performed at the first stage, and a case-parent/case-sibling study is performed at the second stage on a random subsample of the first-stage case sample as well as their parents/unaffected siblings. Statistical inference procedures are developed for the proposed two-stage study designs, which not only preserve the robustness property of the family-based analysis, but also utilize information from the case-only analysis to enhance estimation efficiency and testing power. Simulation results reveal both the robustness and efficiency of the proposed strategies. Genet. Epidemiol. 2008. © 2008 Wiley-Liss, Inc.en_US
dc.format.extent 151636 bytes-
dc.format.mimetype application/pdf-
dc.language.iso en_US-
dc.relation (關聯) Genet Epidemiol, 33(2), 95-104en_US
dc.subject (關鍵詞) case-parent studies;case-sibling studies;gene-environment independence;parental missingnessen_US
dc.title (題名) Two-stage analysis for gene-environment interaction utilizing both case-only and family-based analysisen_US
dc.type (資料類型) articleen
dc.identifier.doi (DOI) 10.1002/gepi.20357en_US
dc.doi.uri (DOI) http://dx.doi.org/10.1002/gepi.20357en_US