Please use this identifier to cite or link to this item:
https://ah.lib.nccu.edu.tw/handle/140.119/110181
DC Field | Value | Language |
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dc.contributor | 神科所 | |
dc.creator | 詹銘煥 | zh_TW |
dc.creator | Lin, Jen-Cheng;Lee, Mei-Yi;Chan, Ming-Huan;Chen, Yi-Chyan;Chen, Hwei-Hsien | |
dc.date | 2016-09 | |
dc.date.accessioned | 2017-06-05T06:45:04Z | - |
dc.date.available | 2017-06-05T06:45:04Z | - |
dc.date.issued | 2017-06-05T06:45:04Z | - |
dc.identifier.uri | http://nccur.lib.nccu.edu.tw/handle/140.119/110181 | - |
dc.description.abstract | Ketamine is emerging as a new hope against depression, but ketamine-associated psychotomimetic effects limit its clinical use. An adjunct therapy along with ketamine to alleviate its adverse effects and even potentiate the antidepressant effects might be an alternative strategy. Betaine, a methyl derivative of glycine and a dietary supplement, has been shown to have antidepressant-like effects and to act like a partial agonist at the glycine site of N-methyl-D-aspartate receptors (NMDARs). Accordingly, betaine might have potential to be an adjunct to ketamine treatment for depression. The antidepressant-like effects of ketamine and betaine were evaluated by forced swimming test and novelty suppressed feeding test in mice. Both betaine and ketamine produced antidepressant-like effects. Furthermore, we determined the effects of betaine on ketamine-induced antidepressant-like and psychotomimetic behaviors, motor incoordination, hyperlocomotor activity, and anesthesia. The antidepressant-like responses to betaine combined with ketamine were stronger than their individual effects. In contrast, ketamine-induced impairments in prepulse inhibition, novel object recognition test, social interaction, and rotarod test were remarkably attenuated, whereas ketamine-induced hyperlocomotion and loss of righting reflex were not affected by betaine. These findings revealed that betaine could enhance the antidepressant-like effects, yet block the psychotomimetic effects of ketamine, suggesting that betaine can be considered as an add-on therapy to ketamine for treatment-resistant depression and suitable for the treatment of depressive symptoms in patients with schizophrenia. | |
dc.format.extent | 659600 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.relation | Psychopharmacology, Vol.233, Issue 17, pp.3223-35 | |
dc.subject | Behavior ; NMDA receptor ; Depression ; Schizophrenia ; Prepulse inhibition | |
dc.title | Betaine enhances antidepressant-like, but blocks psychotomimetic effects of ketamine in mice | |
dc.type | article | |
dc.identifier.doi | 10.1007/s00213-016-4359-x | |
dc.doi.uri | http://dx.doi.org/10.1007/s00213-016-4359-x | |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | restricted | - |
item.openairetype | article | - |
Appears in Collections: | 期刊論文 |
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3223-35.pdf | 644.14 kB | Adobe PDF2 | View/Open |
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