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Please use this identifier to cite or link to this item: https://ah.lib.nccu.edu.tw/handle/140.119/108121
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dc.contributor.advisor蔡尚岳zh_TW
dc.contributor.advisorTsai, Shang Yuehen_US
dc.contributor.author粘政緯zh_TW
dc.contributor.authorNien, Cheng Weien_US
dc.creator粘政緯zh_TW
dc.creatorNien, Cheng Weien_US
dc.date2017en_US
dc.date.accessioned2017-04-05T07:37:10Z-
dc.date.available2017-04-05T07:37:10Z-
dc.date.issued2017-04-05T07:37:10Z-
dc.identifierG0103755014en_US
dc.identifier.urihttp://nccur.lib.nccu.edu.tw/handle/140.119/108121-
dc.description碩士zh_TW
dc.description國立政治大學zh_TW
dc.description應用物理研究所zh_TW
dc.description103755014zh_TW
dc.description.abstract乳酸(Lactate)是一種人體內常見的代謝物，也是無氧代謝後的最終產物。人體在運動過後血液中的乳酸濃度會上升，但在一般情況下大腦中的乳酸含量非常低，正常人腦乳酸濃度約低於0.5毫莫耳(mM)，由於腦乳酸的低濃度，以及在磁共振頻譜中的乳酸訊號與大分子(macromolecular)部分訊號重疊，導致在正常大腦中不易得到乳酸的頻譜訊號。近年來，有文獻指出在3T的磁場下利用MEGA-PRESS技術可以量測到乳酸在大腦經由低氧與高氧交替過程中的改變，而Mescher-Garwood(MAGA) point-resolved spectroscopy sequence(PRESS)頻譜編輯技術是由原本的PRESS脈衝序列再增加兩個選擇性的脈衝，透過頻譜相減消除不具有J-耦合特性的代謝物，來針對具有J-耦合特性的代謝物訊號做測量。本研究的目的為在3T的磁場下，利用MEGA-PRESS技術量到乳酸的頻譜訊號之外，再藉由不同的擬合(fitting)方式以及處理頻譜平均次數來得到不同條件下乳酸頻譜的標準差及變異係數值，以衡量利用在視覺刺激下是否能得到大腦視覺區中乳酸的改變差異，並提供一份乳酸對擬合參數的改變及平均次數多寡的參考依據。zh_TW
dc.description.tableofcontents中文摘要 Ⅱ\n目錄 Ⅲ\n圖目錄 Ⅳ\n表目錄 Ⅶ\n第一章 簡介 1\n1-1背景介紹 1\n1-2文獻回顧 1\n1-3研究動機 4\n1-4組織架構 4\n第二章 原理 7\n2-1磁共振原理 7\n2-2化學位移 9\n2-3 J耦合 11\n2-4 MEGA-PRESS頻譜編輯技術 13\n第三章 實驗步驟與方法 17\n3-1受試者與實驗方法 17\n3-2實驗過程與參數 17\n3-3頻譜處理方式 18\n3-4擬合參數使用 21\n3-5數據分析 22\n第四章 結果 24\n4-1不同時間分辨率下乳酸加大分子頻譜 24\n4.2乳酸加大分子曲線擬合誤差 26\n4.3乳酸加大分子量化數值與變異係數 29\n第五章 討論與結論 35\n5-1討論 35\n5-2結論 39\n參考資料 40zh_TW
dc.format.extent1874345 bytes-
dc.format.mimetypeapplication/pdf-
dc.source.urihttp://thesis.lib.nccu.edu.tw/record/#G0103755014en_US
dc.subject磁共振頻譜zh_TW
dc.subject耦合zh_TW
dc.subjectMEGA-PRESSen_US
dc.title以MEGA-PRESS頻譜編輯技術偵測大腦乳酸 及探討平均頻譜次數與擬合參數之影響zh_TW
dc.titleThe detection of lactate in human brain using MEGA-PRESS spectral editing technique and the affect between times of average spectrum and fitting parametersen_US
dc.typethesisen_US
dc.relation.reference[1] M.Mescher, H.Merkle, J.Kirsch,M.Garwood, and R.Gruetter, "Simultaneous in vivo spectral editing and water suppression,"NMR in Biomedicine,vol.11, pp.266-272,1998.\n\n[2] Richard A.E.Edden, Ashley D.Harris, and Kevin Murphy,"Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia,"(2010) \n\n[3] Yan Lin, Mary C Stephenson, and Lijing Xin, "Investigating the metabolic changes due to visual stimulation using functional proton magnetic resonance spectroscopy at 7T,"(2012)\n\n[4] Ashley D.Harris, Victoria H.Roberton, and Danielle L.Huckle, "Temporal dynamics of Lactate concentration in the human brain during acute inspiratory hypoxia,"(2013)\n\n[5] Jaime M.Ross, Johanna Öberg, and Stefan Brené, "High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio,"(2010)\n\n[6] D.Lau, N.Klein, and B.Cunha, "Brain abscess mimisking brain tumor," Heart & Lung：the journal of critical care,vol.18,pp.634-637,1989\n\n[7] V.Govindaraju,K.Young,and A.A.Maudsley,"Proton NMR chemical shifts and constant for brain metabolites,"NMR in Biomedicine,vol.13,pp.129-153,2000.\n\n\n[8] Sean Hansen-Romu, "Simulation of the Ultra-Cold Neutron Spin Analyzer Foil." ,p14,(2015)\n\n[9] 陳志宏、張允中和謝昭賢等編著。第15 章核磁共振與磁振造影 "Nuclear Magnetic \nResonanceand Magnetic Resonance Imaging", p10.\n\n[10] Ray H. Hashemi, William G. Bradley, Christopher J. Lisanti. "MRI the basics." Lippincott Williams & Wilkins (2004).\n\n[11] Robin A. de Graaf. "In Vivo NMR Spectroscopy" 2nd Edition , John \nWiley & Sons, Ltd (2007)zh_TW
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