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https://ah.lib.nccu.edu.tw/handle/140.119/112534
題名: | Microstructural integrity of cerebral fiber tracts in hereditary spastic paraparesis with SPG11 mutation. | 作者: | 楊啟正 Pan, M.-K. Huang, S.-C. Lo, Y.-C. Yang, Chih-Chao Cheng, T.-W. Yang, Chi-Cheng Hua, M.-S. Tseng, M.-J. Lee and W.-Y.I. |
貢獻者: | 心理系 | 日期: | May-2013 | 上傳時間: | 6-Sep-2017 | 摘要: | BACKGROUND AND PURPOSE: ARHSP-TCC is characterized by progressive leg spasticity, ataxia, and cognitive dysfunction. Although mutations in the human SPG11 gene were identified as responsible for ARHSP-TCC, the cerebral fiber integrity has not been assessed systemically. The objective of this study was to assess cerebral fiber integrity and its clinical significance in patients with ARHSP-TCC. MATERIALS AND METHODS: Five patients from 2 families who were clinically and genetically confirmed to have ARHSP-TCC were examined by neuropsychological evaluation and DSI of the brain. We performed voxel-based GFA analysis for global white matter evaluation, tractography-based analysis for tract-to-tract comparisons, and tract-specific analysis of the CST to evaluate microstructural integrity along the axonal direction. | 關聯: | American Journal of Nuclear Radiology, Vol.34, No.5, pp.990-996 | 資料類型: | article | DOI: | https://doi.org/10.3174/ajnr.A3330 |
Appears in Collections: | 期刊論文 |
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