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https://ah.lib.nccu.edu.tw/handle/140.119/120101
題名: | Effect of Pachybasin on General Toxicity and Developmental Toxicity in Vivo | 作者: | Lin, Yi-Ruu;Peng, Kou-Cheng;Chan, Ming-Huan;Peng, Huan-Lin;Liu, Shu-Ying 詹銘煥 Chan, Ming-Huan |
貢獻者: | 神科所 | 關鍵詞: | Trichoderma harzianum; developmental toxicity; general toxicity; pachybasin | 日期: | Dec-2017 | 上傳時間: | 17-Sep-2018 | 摘要: | To document the safety of pachybasin, a secondary metabolite of Trichoderma harzianum, for use as a bioagricultural agent, it was subjected to general toxicological testing in mice and developmental toxicity in zebrafish. With either 5 or 20 mg kg-1 pachybasin i.p. injection, mice behavioral responses such as motor coordination, spontaneous locomotor activity, or nociceptive pain were not influenced. In long-term effect (daily injection for 14 days), the physiological, hematological, liver, and kidney functions were not altered either. Evidence for the developmental toxicity of pachybasin (10-100 μM) in 72-h exposure period was shown in zebrafish larvae, based on developmental retardation, impairment of chorion, and increase of mortality. In summary, there are no significant general toxicities presented in the pachybasin-treated adult male mice. However, the embryo-toxicity in aquatic biota should be taken into consideration during bioagricultural agent application. | 關聯: | J. Agric. Food Chem. 65, 48, 10489-10494 PMID: 29111710 |
資料類型: | article | DOI: | https://doi.org/10.1021/acs.jafc.7b03879 |
Appears in Collections: | 期刊論文 |
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