Please use this identifier to cite or link to this item:
https://ah.lib.nccu.edu.tw/handle/140.119/80587
DC Field | Value | Language |
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dc.contributor | 神科所 | |
dc.creator | Liu, B.R.;Chen, H.H.;Chan, M.H.;Huang, Y.W.;Aronstam, R.S;Lee, H.J.* | |
dc.date | 2015 | |
dc.date.accessioned | 2016-01-14T09:57:16Z | - |
dc.date.available | 2016-01-14T09:57:16Z | - |
dc.date.issued | 2016-01-14T09:57:16Z | - |
dc.identifier.uri | http://nccur.lib.nccu.edu.tw/handle/140.119/80587 | - |
dc.description.abstract | Nanoparticles, such as semiconductor quantum dots (QDs), have been found increasing use in biomedical diagnosis and therapeutics because of their unique properties, including quantum confinement, surface plasmon resonance, and superparamagnetism. Cell-penetrating peptides (CPPs) represent an efficient mechanism to overcome plasma membrane barriers and deliver biologically active molecules into cells. In this study, we demonstrate that three arginine-rich CPPs (SR9, HR9, and PR9) can noncovalently complex with red light emitting QDs, dramatically increasing their delivery into living cells. Zeta-potential and size analyses highlight the importance of electrostatic interactions between positive-charged CPP/QD complexes and negative-charged plasma membranes indicating the efficiency of transmembrane complex transport. Subcellular colocalization indicates associations of QD with early endosomes and lysosomes following PR9-mediated delivery. Our study demonstrates that nontoxic CPPs of varied composition provide an effective vehicle for the design of optimized drug delivery systems. | |
dc.format.extent | 107 bytes | - |
dc.format.mimetype | text/html | - |
dc.relation | Journal of Nanoscience and Nanotechnology, 15, 2067-2078. | |
dc.title | Three arginine-rich cell-penetrating peptides facilitate cellular internalization of red-emitting quantum dots | |
dc.type | article | |
dc.identifier.doi | 10.1166/jnn.2015.9148 | |
dc.doi.uri | http://dx.doi.org/10.1166/jnn.2015.9148 | |
item.fulltext | With Fulltext | - |
item.grantfulltext | restricted | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | 期刊論文 |
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