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題名 Laminin B1抑制ERK1/2及SGK1的活化進而抑制大白鼠空間記憶的形成
Laminin B1 impairs spatial memry formation in rats through inhibition of ERK1/2 and SGK1 activity
作者 劉文婷
貢獻者 李小媛
劉文婷
關鍵詞 學習與記憶
層黏蛋白
SGK
Laminin B1
日期 2009
上傳時間 9-May-2016 15:29:56 (UTC+8)
摘要 層黏蛋白 (laminin) 是基底膜內主要的糖蛋白，屬於細胞外基質。研究指出層黏蛋白在學習與記憶扮演重要角色，且內生性laminin β1表現於海馬迴神經，但是目前對於層黏蛋白在中樞神經的瞭解仍不是很清楚。因此，本實驗室利用水迷津學習實驗探討laminin β1對大白鼠空間學習與記憶的影響，實驗結果發現，經過學習試驗後的大白鼠，其海馬迴CA1區域的laminin β1 mRNA和蛋白質表現量明顯地減少，laminin β2的表現則不受到影響。為瞭解laminin β1在空間學習與記憶力程中扮演的角色及其下游的訊息傳遞路徑，我們轉染laminin β1 siRNA至海馬迴CA1區域會促進大白鼠在水迷津空間學習與記憶的能力，由西方墨點法也觀察到抑制海馬迴中laminin β1的表現量會促進SGK Ser422及ERK1/2的磷酸化，但是AKT Ser473的磷酸化則無顯著差異。當轉染質體基因laminin β1至CA1區域，則會抑制大白鼠水迷津空間學習與記憶的能力，同時也抑制SGK Ser422及ERK1/2的磷酸化。由於過去證實SGK1於大白鼠空間學習記憶歷程中扮演重要角色，我們推測laminin β1與SGK Ser422的磷酸化有關，為確認laminin β1與SGK1之間的關係，我們同時轉染laminin β1 siRNA和SGK siRNA至海馬迴CA1區域，原先laminin β1促進大白鼠在水迷津空間學習與記憶的能力反而受到抑制。由於許多文獻指出mitogen-activated protein kinase /extracellular signal-regulated kinase (MAPK/ERK) 能整合不同訊息傳遞路徑進而調控基因的表現，對神經突觸的可塑性及記憶的形成是個重要分子，我們進一步探討laminin β1是否透過ERK1/2調控下游的SGK1進而影響大白鼠的空間記憶與學習。因此我們先轉染laminin β1 siRNA，48小時後再給予U0126 (MEK抑制劑) 以抑制MAPK/ERK的活性。結果顯示U0126會阻斷laminin β1所引起SGK ser422的磷酸化。本篇研究提出laminin β1會參與哺乳類動物學習記憶的形成，同時也證實laminin β1會經由抑制ERK1/2及SGK1的活化進而抑制大白鼠空間學習與記憶的形成。
參考文獻 Abdallah B, Hassan A, Benoist C, Goula D, Behr JP, Demeneix BA (1996) A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum Gene Ther 7:1947-1954.
     Adams JP, Sweatt JD (2002) Molecular psychology: roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol 42:135-163.
     Adriani W, Leo D, Guarino M, Natoli A, Di Consiglio E, De Angelis G, Traina E, Testai E, Perrone-Capano C, Laviola G (2006) Short-term effects of adolescent methylphenidate exposure on brain striatal gene expression and sexual/endocrine parameters in male rats. Ann N Y Acad Sci 1074:52-73.
     Amaral DG, Witter MP (1989) The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience 31:571-591.
     Amet LE, Lauri SE, Hienola A, Croll SD, Lu Y, Levorse JM, Prabhakaran B, Taira T, Rauvala H, Vogt TF (2001) Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule. Mol Cell Neurosci 17:1014-1024.
     Arbabi S, Maier RV (2002) Mitogen-activated protein kinases. Crit Care Med 30:S74-S79.
     Atkins CM, Selcher JC, Petraitis JJ, Trzaskos JM, Sweatt JD (1998) The MAPK cascade is required for mammalian associative learning. Nat Neurosci 1:602-609.
     Bahr BA, Staubli U, Xiao P, Chun D, Ji ZX, Esteban ET, Lynch G (1997) Arg-Gly-Asp-Ser-selective adhesion and the stabilization of long-term potentiation: pharmacological studies and the characterization of a candidate matrix receptor. J Neurosci 17:1320-1329.
     Becker CG, Artola A, Gerardy-Schahn R, Becker T, Welzl H, Schachner M (1996) The polysialic acid modification of the neural cell adhesion molecule is involved in spatial learning and hippocampal long-term potentiation. J Neurosci Res 45:143-152.
     Bell LM, Leong ML, Kim B, Wang E, Park J, Hemmings BA, Firestone GL (2000) Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK- dependent pathway. J Biol Chem 275:25262-25272.
     Bird CM, Burgess N (2008) The hippocampus and memory: insights from spatial processing. Nat Rev Neurosci 9:182-194.
     Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
     Blum S, Moore AN, Adams F, Dash PK (1999) A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory. J Neurosci 19:3535-3544.
     Boletta A, Benigni A, Lutz J, Remuzzi G, Soria MR, Monaco L (1997) Nonviral gene delivery to the rat kidney with polyethylenimine. Hum Gene Ther 8:1243-1251.
     Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD (1991) ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65:663-675.
     Bovet D, Bovet-Nitti F, Oliverio A (1968) Memory and consolidation mechanisms in avoidance learning of inbred mice. Brain Res 10:168-182.
     Burgeson RE, Chiquet M, Deutzmann R, Ekblom P, Engel J, Kleinman H, Martin GR, Meneguzzi G, Paulsson M, Sanes J, et al. (1994) A new nomenclature for the laminins. Matrix Biol 14:209-211.
     Burwell RD, Witter MP, Amaral DG (1995) Perirhinal and postrhinal cortices of the rat: a review of the neuroanatomical literature and comparison with findings from the monkey brain. Hippocampus 5:390-408.
     Calof AL, Campanero MR, O`Rear JJ, Yurchenco PD, Lander AD (1994) Domain-specific activation of neuronal migration and neurite outgrowth-promoting activities of laminin. Neuron 13:117-130.
     Castren E, Pitkanen M, Sirvio J, Parsadanian A, Lindholm D, Thoenen H, Riekkinen PJ (1993) The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus. Neuroreport 4:895-898.
     Chan CS, Weeber EJ, Kurup S, Sweatt JD, Davis RL (2003) Integrin requirement for hippocampal synaptic plasticity and spatial memory. J Neurosci 23:7107-7116.
     Chan CS, Weeber EJ, Zong L, Fuchs E, Sweatt JD, Davis RL (2006) Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory. J Neurosci 26:223-232.
     Chan CS, Levenson JM, Mukhopadhyay PS, Zong L, Bradley A, Sweatt JD, Davis RL (2007) Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Learn Mem 14:606- 615.
     Chao CC, Ma YL, Lee EH (2007) Protein kinase CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling: activation of Akt and inactivation of SGK1. J Neurosci 27:6243-6248.
     Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D (1999) Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci U S A 96:2514-2519.
     Chen ZL, Indyk JA, Strickland S (2003) The hippocampal laminin matrix is dynamic and critical for neuronal survival. Mol Biol Cell 14:2665- 2676.
     Cheng YS, Champliaud MF, Burgeson RE, Marinkovich MP, Yurchenco PD (1997) Self-assembly of laminin isoforms. J Biol Chem 272: 31525-31532.
     Chun SJ, Rasband MN, Sidman RL, Habib AA, Vartanian T (2003) Integrin-linked kinase is required for laminin-2-induced oligo- dendrocyte cell spreading and CNS myelination. J Cell Biol 163: 397-408.
     Coccia EM, Del Russo N, Stellacci E, Testa U, Marziali G, Battistini A (1999) STAT1 activation during monocyte to macrophage maturation: role of adhesion molecules. Int Immunol 11:1075-1083.
     Coitinho AS, Freitas AR, Lopes MH, Hajj GN, Roesler R, Walz R, Rossato JI, Cammarota M, Izquierdo I, Martins VR, Brentani RR (2006) The interaction between prion protein and laminin modulates memory consolidation. Eur J Neurosci 24:3255-3264.
     Coogan AN, O`Leary DM, O`Connor JJ (1999) P42/44 MAP kinase inhibitor PD98059 attenuates multiple forms of synaptic plasticity in rat dentate gyrus in vitro. J Neurophysiol 81:103-110.
     D`Arcangelo G (2005) Apoer2: a reelin receptor to remember. Neuron 47: 471-473.
     David S, Kalb RG (2005) Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB. FEBS Lett 579:1534-1538.
     Davis HP, Spanis CW, Squire LR (1976) Inhibition of cerebral protein synthesis: performance at different times after passive avoidance training. Pharmacol Biochem Behav 4:13-16.
     Davis HP, Rosenzweig MR, Grove EA, Bennett EL (1984) Investigation of the reported protective effect of cycloheximide on memory. Pharmacol Biochem Behav 20:405-413.
     Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Munster C, Chraibi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O (2001) Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J 20: 7052-7059.
     Delwel GO, Hogervorst F, Sonnenberg A (1996) Cleavage of the alpha6A subunit is essential for activation of the alpha6Abeta1 integrin by phorbol 12-myristate 13-acetate. J Biol Chem 271:7293-7296.
     Durbeej M (2009) Laminins. Cell Tissue Res.
     Evers MR, Salmen B, Bukalo O, Rollenhagen A, Bosl MR, Morellini F, Bartsch U, Dityatev A, Schachner M (2002) Impairment of L-type Ca2+ channel-dependent forms of hippocampal synaptic plasticity in mice deficient in the extracellular matrix glycoprotein tenascin-C. J Neurosci 22:7177-7194.
     Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623 -18632.
     Firestone GL, Giampaolo JR, O`Keeffe BA (2003) Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 13:1-12.
     Fukazawa Y, Saitoh Y, Ozawa F, Ohta Y, Mizuno K, Inokuchi K (2003) Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. Neuron 38:447-460.
     Goelet P, Castellucci VF, Schacher S, Kandel ER (1986) The long and the short of long-term memory--a molecular framework. Nature 322: 419- 422.
     Grewal SS, York RD, Stork PJ (1999) Extracellular-signal-regulated kinase signalling in neurons. Curr Opin Neurobiol 9:544-553.
     Gruenbaum LM, Carew TJ (1999) Growth factor modulation of substrate-specific morphological patterns in Aplysia bag cell neurons. Learn Mem 6:292-306.
     Gubler MC (2008) Inherited diseases of the glomerular basement membrane. Nat Clin Pract Nephrol 4:24-37.
     Hebb DO (1949) The organization of behavior, Wiley, New York.
     Henry MD, Campbell KP (1996) Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton. Curr Opin Cell Biol 8:625-631.
     Hoffman KB, Martinez J, Lynch G (1998) Proteolysis of cell adhesion molecules by serine proteases: a role in long term potentiation? Brain Res 811:29-33.
     Hollister RD, Page KJ, Hyman BT (1997) Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: effects of excitotoxic hippocampal lesions. Neuroscience 79: 1111- 1119.
     Horwood JM, Dufour F, Laroche S, Davis S (2006) Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. Eur J Neurosci 23:3375-3384.
     Hsu WL, Chiu TH, Tai DJ, Ma YL, Lee EH (2009) A novel defense mechanism that is activated on amyloid-beta insult to mediate cell survival: role of SGK1-STAT1/STAT2 signaling. Cell Death Differ 16:1515-1529.
     Huang Z, Shimazu K, Woo NH, Zang K, Muller U, Lu B, Reichardt LF (2006) Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse. J Neurosci 26:11208-11219.
     Indyk JA, Chen ZL, Tsirka SE, Strickland S (2003) Laminin chain expression suggests that laminin-10 is a major isoform in the mouse hippocampus and is degraded by the tissue plasminogen activator/plasmin protease cascade during excitotoxic injury. Neuroscience 116:359-371.
     Ishizuka N, Cowan WM, Amaral DG (1995) A quantitative analysis of the dendritic organization of pyramidal cells in the rat hippocampus. J Comp Neurol 362:17-45.
     Jones PL, Jones FS (2000) Tenascin-C in development and disease: gene regulation and cell function. Matrix Biol 19:581-596.
     Kesner RP, Hardy JD (1983) Long-term memory for contextual attributes: dissociation of amygdala and hippocampus. Behav Brain Res 8:139-149.
     Kiernan BW, Garcion E, Ferguson J, Frost EE, Torres EM, Dunnett SB, Saga Y, Aizawa S, Faissner A, Kaur R, Franklin RJ, ffrench- Constant C (1999) Myelination and behaviour of tenascin-C null transgenic mice. Eur J Neurosci 11:3082-3092.
     Kobayashi T, Cohen P (1999) Activation of serum- and glucocorticoid- regulated protein kinase by agonists that activate phosphatidy- linositide 3-kinase is mediated by 3-phosphoinositide -dependent protein kinase-1 (PDK1) and PDK2. Biochem J 339 ( Pt 2):319-328.
     Kobayashi T, Deak M, Morrice N, Cohen P (1999) Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J 344 Pt 1:189-197.
     Korte M, Staiger V, Griesbeck O, Thoenen H, Bonhoeffer T (1996) The involvement of brain-derived neurotrophic factor in hippocampal long-term potentiation revealed by gene targeting experiments. J Physiol Paris 90:157-164.
     Kramar EA, Bernard JA, Gall CM, Lynch G (2002) Alpha3 integrin receptors contribute to the consolidation of long-term potentiation. Neuroscience 110:29-39.
     Krucker T, Siggins GR, Halpain S (2000) Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus. Proc Natl Acad Sci U S A 97:6856-6861.
     Lacourse MG, Orr EL, Cramer SC, Cohen MJ (2005) Brain activation during execution and motor imagery of novel and skilled sequential hand movements. Neuroimage 27:505-519.
     Lang F, Cohen P (2001) Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci STKE 2001: RE17.
     Lauri SE, Kaukinen S, Kinnunen T, Ylinen A, Imai S, Kaila K, Taira T, Rauvala H (1999) Reg1ulatory role and molecular interactions of a cell-surface heparan sulfate proteoglycan (N-syndecan) in hippocampal long-term potentiation. J Neurosci 19:1226-1235.
     Lee CT, Tyan SW, Ma YL, Tsai MC, Yang YC, Lee EH (2006) Serum- and glucocorticoid-inducible kinase (SGK) is a target of the MAPK/ERK signaling pathway that mediates memory formation in rats. Eur J Neurosci 23:1311-1320.
     Lee EH, Hsu WL, Ma YL, Lee PJ, Chao CC (2003) Enrichment enhances the expression of sgk, a glucocorticoid-induced gene, and facilitates spatial learning through glutamate AMPA receptor mediation. Eur J Neurosci 18:2842-2852.
     Legate KR, Wickstrom SA, Fassler R (2009) Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev 23:397-418.
     Leong ML, Maiyar AC, Kim B, O`Keeffe BA, Firestone GL (2003) Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J Biol Chem 278:5871-5882.
     Libby RT, Lavallee CR, Balkema GW, Brunken WJ, Hunter DD (1999) Disruption of laminin beta2 chain production causes alterations in morphology and function in the CNS. J Neurosci 19:9399-9411.
     Liesi P, Dahl D, Vaheri A (1983) Laminin is produced by early rat astrocytes in primary culture. J Cell Biol 96:920-924.
     Liesi P, Fried G, Stewart RR (2001) Neurons and glial cells of the embryonic human brain and spinal cord express multiple and distinct isoforms of laminin. J Neurosci Res 64:144-167.
     Liu SJ, Zhang AH, Li HL, Wang Q, Deng HM, Netzer WJ, Xu H, Wang JZ (2003) Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. J Neurochem 87:1333-1344.
     Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408.
     Lopez-Colome AM, Ortega A (1997) Activation of p42 mitogen-activated protein kinase by glutamate in cultured radial glia. Neurochem Res 22:679-685.
     Luthl A, Laurent JP, Figurov A, Muller D, Schachner M (1994) Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM. Nature 372:777-779.
     Ma YL, Tsai MC, Hsu WL, Lee EH (2006) SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons. Learn Mem 13:114-118.
     Maiyar AC, Phu PT, Huang AJ, Firestone GL (1997) Repression of glucocorticoid receptor transactivation and DNA binding of a glucocorticoid response element within the serum/ glucocorticoid -inducible protein kinase (sgk) gene promoter by the p53 tumor suppressor protein. Mol Endocrinol 11:312-329.
     Maiyar AC, Huang AJ, Phu PT, Cha HH, Firestone GL (1996) p53 stimulates promoter activity of the sgk. serum/glucocorticoid -inducible serine/threonine protein kinase gene in rodent mammary epithelial cells. J Biol Chem 271:12414-12422.
     Mazzucchelli C, Vantaggiato C, Ciamei A, Fasano S, Pakhotin P, Krezel W, Welzl H, Wolfer DP, Pages G, Valverde O, Marowsky A, Porrazzo A, Orban PC, Maldonado R, Ehrengruber MU, Cestari V, Lipp HP, Chapman PF, Pouyssegur J, Brambilla R (2002) Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron 34: 807- 820.
     McGaugh JL, Cahill L, Roozendaal B (1996) Involvement of the amygdala in memory storage: interaction with other brain systems. Proc Natl Acad Sci U S A 93:13508-13514.
     McNaughton BL, Barnes CA, Meltzer J, Sutherland RJ (1989) Hippocampal granule cells are necessary for normal spatial learning but not for spatially-selective pyramidal cell discharge. Exp Brain Res 76:485-496.
     Meighan SE, Meighan PC, Choudhury P, Davis CJ, Olson ML, Zornes PA, Wright JW, Harding JW (2006) Effects of extracellular matrix- degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticity. J Neurochem 96:1227-1241.
     Milner B, Squire LR, Kandel ER (1998) Cognitive neuroscience and the study of memory. Neuron 20:445-468.
     Miner JH (2008) Laminins and their roles in mammals. Microsc Res Tech 71:349-356.
     Miner JH, Patton BL, Lentz SI, Gilbert DJ, Snider WD, Jenkins NA, Copeland NG, Sanes JR (1997) The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. J Cell Biol 137:685-701.
     Mizuno H, Nishida E (2001) The ERK MAP kinase pathway mediates induction of SGK (serum- and glucocorticoid-inducible kinase) by growth factors. Genes Cells 6:261-268.
     Mizuno M, Yamada K, He J, Nakajima A, Nabeshima T (2003) Involvement of BDNF receptor TrkB in spatial memory formation. Learn Mem 10:108-115.
     Moore SA, Saito F, Chen J, Michele DE, Henry MD, Messing A, Cohn RD, Ross-Barta SE, Westra S, Williamson RA, Hoshi T, Campbell KP (2002) Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. Nature 418:422-425.
     Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47-60.
     Moser E, Moser MB, Andersen P (1993) Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J Neurosci 13:3916-3925.
     Moser MB, Moser EI, Forrest E, Andersen P, Morris RG (1995) Spatial learning with a minislab in the dorsal hippocampus. Proc Natl Acad Sci U S A 92:9697-9701.
     Muller D, Wang C, Skibo G, Toni N, Cremer H, Calaora V, Rougon G, Kiss JZ (1996) PSA-NCAM is required for activity-induced synaptic plasticity. Neuron 17:413-422.
     Nakagami Y, Abe K, Nishiyama N, Matsuki N (2000) Laminin degradation by plasmin regulates long-term potentiation. J Neurosci 20: 2003- 2010.
     Noakes PG, Miner JH, Gautam M, Cunningham JM, Sanes JR, Merlie JP (1995) The renal glomerulus of mice lacking s-laminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1. Nat Genet 10:400-406.
     O`Keefe J, Dostrovsky J (1971) The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res 34:171-175.
     Oitzl MS, Reichardt HM, Joels M, de Kloet ER (2001) Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory. Proc Natl Acad Sci U S A 98:12790-12795.
     Packard MG, Hirsh R, White NM (1989) Differential effects of fornix and caudate nucleus lesions on two radial maze tasks: evidence for multiple memory systems. J Neurosci 9:1465-1472.
     Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA (1999) Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 18:3024-3033.
     Parsons MJ, Pollard SM, Saude L, Feldman B, Coutinho P, Hirst EM, Stemple DL (2002) Zebrafish mutants identify an essential role for laminins in notochord formation. Development 129:3137-3146.
     Patterson SL, Grover LM, Schwartzkroin PA, Bothwell M (1992) Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9:1081-1088.
     Patton BL (2000) Laminins of the neuromuscular system. Microsc Res Tech 51:247-261.
     Patton BL, Miner JH, Chiu AY, Sanes JR (1997) Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice. J Cell Biol 139:1507-1521.
     Pavlov I, Voikar V, Kaksonen M, Lauri SE, Hienola A, Taira T, Rauvala H (2002) Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice. Mol Cell Neurosci 20:330-342.
     Paxinos G, Watson CR, Emson PC (1980) AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. J Neurosci Methods 3:129-149.
     Richards JS, Fitzpatrick SL, Clemens JW, Morris JK, Alliston T, Sirois J (1995) Ovarian cell differentiation: a cascade of multiple hormones, cellular signals, and regulated genes. Recent Prog Horm Res 50:223-254.
     Roozendaal B, Portillo-Marquez G, McGaugh JL (1996) Basolateral amygdala lesions block glucocorticoid-induced modulation of memory for spatial learning. Behav Neurosci 110:1074-1083.
     Rousse I, Beaulieu S, Rowe W, Meaney MJ, Barden N, Rochford J (1997) Spatial memory in transgenic mice with impaired glucocorticoid receptor function. Neuroreport 8:841-845.
     Sandi C, Merino JJ, Cordero MI, Kruyt ND, Murphy KJ, Regan CM (2003) Modulation of hippocampal NCAM polysialylation and spatial memory consolidation by fear conditioning. Biol Psychiatry 54:599-607.
     Sandi C, Cordero MI, Merino JJ, Kruyt ND, Regan CM, Murphy KJ (2004) Neurobiological and endocrine correlates of individual differences in spatial learning ability. Learn Mem 11:244-252.
     Sarazin M, Deweer B, Merkl A, Von Poser N, Pillon B, Dubois B (2002) Procedural learning and striatofrontal dysfunction in Parkinson`s disease. Mov Disord 17:265-273.
     Schlaepfer DD, Hunter T (1998) Integrin signalling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol 8:151-157.
     Schubert D (1991) The possible role of adhesion in synaptic modification. Trends Neurosci 14:127-130.
     Scoville WB, Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20:11-21.
     Selcher JC, Atkins CM, Trzaskos JM, Paylor R, Sweatt JD (1999) A necessity for MAP kinase activation in mammalian spatial learning. Learn Mem 6:478-490.
     Selcher JC, Weeber EJ, Christian J, Nekrasova T, Landreth GE, Sweatt JD (2003) A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1. Learn Mem 10:26-39.
     Sharif KA, Baker H, Gudas LJ (2004a) Differential regulation of laminin b1 transgene expression in the neonatal and adult mouse brain. Neuroscience 126:967-978.
     Sharif KA, Baker H, Gudas LJ (2004b) Differential regulation of laminin b1 transgene expression in the neonatal and adult mouse brain. In: Neuroscience, 2004/06/23 Edition, pp 967-978.
     Staubli U, Chun D, Lynch G (1998) Time-dependent reversal of long-term potentiation by an integrin antagonist. J Neurosci 18:3460-3469.
     Sunada Y, Bernier SM, Kozak CA, Yamada Y, Campbell KP (1994) Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus. J Biol Chem 269:13729-13732.
     Tai DJ, Su CC, Ma YL, Lee EH (2009) SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression. J Biol Chem 284:4073-4089.
     Talts JF, Andac Z, Gohring W, Brancaccio A, Timpl R (1999) Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins. EMBO J 18:863-870.
     Thomas KL, Hunt SP (1993) The regional distribution of extracellularly regulated kinase-1 and -2 messenger RNA in the adult rat central nervous system. Neuroscience 56:741-757.
     Thompson RF, Krupa DJ (1994) Organization of memory traces in the mammalian brain. Annu Rev Neurosci 17:519-549.
     Timpl R, Rohde H, Robey PG, Rennard SI, Foidart JM, Martin GR (1979) Laminin--a glycoprotein from basement membranes. J Biol Chem 254:9933-9937.
     Tsai KJ, Chen SK, Ma YL, Hsu WL, Lee EH (2002) sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats. Proc Natl Acad Sci U S A 99:3990-3995.
     Tunggal P, Smyth N, Paulsson M, Ott MC (2000) Laminins: structure and genetic regulation. Microsc Res Tech 51:214-227.
     Tyan SW, Tsai MC, Lin CL, Ma YL, Lee EH (2008) Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation. J Neurochem 105:820-832.
     Venero C, Herrero AI, Touyarot K, Cambon K, Lopez-Fernandez MA, Berezin V, Bock E, Sandi C (2006) Hippocampal up-regulation of NCAM expression and polysialylation plays a key role on spatial memory. Eur J Neurosci 23:1585-1595.
     Waldegger S, Gabrysch S, Barth P, Fillon S, Lang F (2000) h-sgk serine-threonine protein kinase as transcriptional target of p38/MAP kinase pathway in HepG2 human hepatoma cells. Cell Physiol Biochem 10:203-208.
     Waldegger S, Klingel K, Barth P, Sauter M, Rfer ML, Kandolf R, Lang F (1999) h-sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine. Gastroenterology 116:1081-1088.
     Warrington EK, Weiskrantz L (1968) New method of testing long-term retention with special reference to amnesic patients. Nature 217:972-974.
     Webster MK, Goya L, Firestone GL (1993a) Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine/threonine protein kinase. J Biol Chem 268:11482-11485.
     Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL (1993b) Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 13:2031-2040.
     Weeber EJ, Beffert U, Jones C, Christian JM, Forster E, Sweatt JD, Herz J (2002) Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem 277: 39944-39952.
     Wiksten M, Vaananen AJ, Liebkind R, Liesi P (2004a) Regeneration of adult rat spinal cord is promoted by the soluble KDI domain of gamma1 laminin. J Neurosci Res 78:403-410.
     Wiksten M, Vaananen A, Liebkind R, Rauhala P, Liesi P (2004b) Soluble KDI domain of gamma1 laminin protects adult hippocampus from excitotoxicity of kainic acid. J Neurosci Res 78:411-419.
     Wright JW, Kramar EA, Meighan SE, Harding JW (2002) Extracellular matrix molecules, long-term potentiation, memory consolidation and the brain angiotensin system. Peptides 23:221-246.
     Wu W, Chaudhuri S, Brickley DR, Pang D, Karrison T, Conzen SD (2004) Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res 64:1757-1764.
     Yang YC, Lin CH, Lee EH (2006) Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau. Mol Cell Biol 26:8357-8370.
     Yin Y, Kikkawa Y, Mudd JL, Skarnes WC, Sanes JR, Miner JH (2003) Expression of laminin chains by central neurons: analysis with gene and protein trapping techniques. Genesis 36:114-127.
     Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22:1532-1540.
     Yurchenco PD, Cheng YS (1994) Laminin self-assembly: a three-arm interaction hypothesis for the formation of a network in basement membranes. Contrib Nephrol 107:47-56.
     Zaccaria ML, Di Tommaso F, Brancaccio A, Paggi P, Petrucci TC (2001) Dystroglycan distribution in adult mouse brain: a light and electron microscopy study. Neuroscience 104:311-324.
     Zhang BH, Tang ED, Zhu T, Greenberg ME, Vojtek AB, Guan KL (2001) Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. J Biol Chem 276:31620-31626.
     Zhou R, Snyder PM (2005) Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation. J Biol Chem 280:4518-4523.
     Zhou XH, Brakebusch C, Matthies H, Oohashi T, Hirsch E, Moser M, Krug M, Seidenbecher CI, Boeckers TM, Rauch U, Buettner R, Gundelfinger ED, Fassler R (2001) Neurocan is dispensable for brain development. Mol Cell Biol 21:5970-5978.
描述 碩士
國立政治大學
生命科學研究所
96754005
資料來源 http://thesis.lib.nccu.edu.tw/record/#G0096754005
資料類型 thesis
dc.contributor.advisor 李小媛zh_TW
dc.contributor.author (Authors) 劉文婷zh_TW
dc.creator (作者) 劉文婷zh_TW
dc.date (日期) 2009en_US
dc.date.accessioned 9-May-2016 15:29:56 (UTC+8)-
dc.date.available 9-May-2016 15:29:56 (UTC+8)-
dc.date.issued (上傳時間) 9-May-2016 15:29:56 (UTC+8)-
dc.identifier (Other Identifiers) G0096754005en_US
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/95274-
dc.description (描述) 碩士zh_TW
dc.description (描述) 國立政治大學zh_TW
dc.description (描述) 生命科學研究所zh_TW
dc.description (描述) 96754005zh_TW
dc.description.abstract (摘要) 層黏蛋白 (laminin) 是基底膜內主要的糖蛋白，屬於細胞外基質。研究指出層黏蛋白在學習與記憶扮演重要角色，且內生性laminin β1表現於海馬迴神經，但是目前對於層黏蛋白在中樞神經的瞭解仍不是很清楚。因此，本實驗室利用水迷津學習實驗探討laminin β1對大白鼠空間學習與記憶的影響，實驗結果發現，經過學習試驗後的大白鼠，其海馬迴CA1區域的laminin β1 mRNA和蛋白質表現量明顯地減少，laminin β2的表現則不受到影響。為瞭解laminin β1在空間學習與記憶力程中扮演的角色及其下游的訊息傳遞路徑，我們轉染laminin β1 siRNA至海馬迴CA1區域會促進大白鼠在水迷津空間學習與記憶的能力，由西方墨點法也觀察到抑制海馬迴中laminin β1的表現量會促進SGK Ser422及ERK1/2的磷酸化，但是AKT Ser473的磷酸化則無顯著差異。當轉染質體基因laminin β1至CA1區域，則會抑制大白鼠水迷津空間學習與記憶的能力，同時也抑制SGK Ser422及ERK1/2的磷酸化。由於過去證實SGK1於大白鼠空間學習記憶歷程中扮演重要角色，我們推測laminin β1與SGK Ser422的磷酸化有關，為確認laminin β1與SGK1之間的關係，我們同時轉染laminin β1 siRNA和SGK siRNA至海馬迴CA1區域，原先laminin β1促進大白鼠在水迷津空間學習與記憶的能力反而受到抑制。由於許多文獻指出mitogen-activated protein kinase /extracellular signal-regulated kinase (MAPK/ERK) 能整合不同訊息傳遞路徑進而調控基因的表現，對神經突觸的可塑性及記憶的形成是個重要分子，我們進一步探討laminin β1是否透過ERK1/2調控下游的SGK1進而影響大白鼠的空間記憶與學習。因此我們先轉染laminin β1 siRNA，48小時後再給予U0126 (MEK抑制劑) 以抑制MAPK/ERK的活性。結果顯示U0126會阻斷laminin β1所引起SGK ser422的磷酸化。本篇研究提出laminin β1會參與哺乳類動物學習記憶的形成，同時也證實laminin β1會經由抑制ERK1/2及SGK1的活化進而抑制大白鼠空間學習與記憶的形成。zh_TW
dc.description.tableofcontents 致 謝 I
     中文摘要 II
     英文摘要 IV
     目 錄 VI
     圖 次 X
     縮寫全名對照表 XI
     第一章 緒 論 1
     第一節、學習與記憶 2
     一、學習與記憶的定義 2
     二、學習與記憶的種類 2
     三、記憶形成之歷程 3
     四、參與學習與記憶的腦區 4
     第二節、空間學習記憶與海馬迴組織 5
     一、海馬迴的構造與投射路徑 5
     二、海馬迴相關的動物行為模式 7
     第三節、神經細胞可塑性 8
     第四節、層黏蛋白家族 10
     一、層黏蛋白的種類 10
     二、層黏蛋白在神經系統中的表現及其功能 11
     三、層黏蛋白與記憶之間的關係 12
     第五節、血清及糖皮質激素誘導激酶 13
     一、血清及糖皮質素誘導激酶的表現及其異構型 13
     二、血清及糖皮質素誘導激酶基因表現的調控機制 15
     三、血清及糖皮質素誘導激酶訊息傳遞路徑的調控 16
     四、血清及糖皮質素誘導激酶參與學習與記憶形成的過程 18
     第六節、細胞外信號調節激酶MAPK/ERK 20
     一、細胞外信號調節激酶的家族及其異構型 20
     二、ERK1/2與學習記憶的關係 22
     第七節、本論文之研究目的與策略 24
     第二章 實驗材料與方法研究 26
     第一節 實驗動物 27
     第二節 水迷津學習試驗 27
     一、實驗儀器 27
     二、隱藏式平台 27
     三、可見式平台 29
     四、組織解剖 29
     第三節 海馬迴CA1區域內基因轉染作用 29
     一、立體定位手術 29
     二、Laminin β1質體製備 30
     三、Laminin β1 siRNA與SGK siRNA的製備 31
     四、質體基因與聚乙烯亞胺 (PEI) 混合物的製備 31
     五、藥物的製備 32
     六、海馬迴CA1區域注射 33
     第四節 西方墨點法 33
     一、蛋白質萃取 33
     二、蛋白質濃度測定法 34
     三、免疫沉澱 34
     四、西方墨點法 35
     第五節 即時定量聚合酶連鎖反應 36
     第六節 免疫組織化學染色 37
     一、組織切片的製備 37
     二、免疫組織化學染色 38
     第七節 統計分析 38
     第三章 實驗結果 40
     第一節 水迷津試驗降低海馬迴CA1區域Laminin β1 mRNA及蛋白質的表現 41
     第二節 抑制海馬迴CA1區域Laminin β1的表現會促進空間記憶的形成 46
     第三節 轉染野生型Laminin β1質體海馬迴CA1區域會抑制水迷津空間記憶的形成 51
     第四節 抑制海馬迴CA1區域Laminin β1的表現會增加ERK1/2及SGK Ser422的磷酸化 55
     第五節 轉染野生型Laminin β1質體至海馬迴CA1區域會抑制ERK1/2及SGK Ser422的磷酸化 57
     第六節 抑制海馬迴CA1區域SGK1的表現會回復Laminin β1下降所造成空間記憶促進的能力 59
     第七節 抑制海馬迴CA1區域MAPK/ERK的活化會回復Laminin β1 siRNA所促進空間學習記憶的形成，同時阻斷Laminin β1將訊息傳遞至SGK1 64
     第四章 討論 69
     第五章 結論 81
     第六章 參考資料 83
     第七章 附錄 97
     附錄一 98
     附錄二 99
     附錄三 100
     附錄四 103
     附錄五 104
     附錄六 105
     附錄七 106
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     致 謝 I
     中文摘要 II
     英文摘要 IV
     目 錄 VI
     圖 次 X
     縮寫全名對照表 XI
     第一章 緒 論 1
     第一節、學習與記憶 2
     一、學習與記憶的定義 2
     二、學習與記憶的種類 2
     三、記憶形成之歷程 3
     四、參與學習與記憶的腦區 4
     第二節、空間學習記憶與海馬迴組織 5
     一、海馬迴的構造與投射路徑 5
     二、海馬迴相關的動物行為模式 7
     第三節、神經細胞可塑性 8
     第四節、層黏蛋白家族 10
     一、層黏蛋白的種類 10
     二、層黏蛋白在神經系統中的表現及其功能 11
     三、層黏蛋白與記憶之間的關係 12
     第五節、血清及糖皮質激素誘導激酶 13
     一、血清及糖皮質素誘導激酶的表現及其異構型 13
     二、血清及糖皮質素誘導激酶基因表現的調控機制 15
     三、血清及糖皮質素誘導激酶訊息傳遞路徑的調控 16
     四、血清及糖皮質素誘導激酶參與學習與記憶形成的過程 18
     第六節、細胞外信號調節激酶MAPK/ERK 20
     一、細胞外信號調節激酶的家族及其異構型 20
     二、ERK1/2與學習記憶的關係 22
     第七節、本論文之研究目的與策略 24
     第二章 實驗材料與方法研究 26
     第一節 實驗動物 27
     第二節 水迷津學習試驗 27
     一、實驗儀器 27
     二、隱藏式平台 27
     三、可見式平台 29
     四、組織解剖 29
     第三節 海馬迴CA1區域內基因轉染作用 29
     一、立體定位手術 29
     二、Laminin β1質體製備 30
     三、Laminin β1 siRNA與SGK siRNA的製備 31
     四、質體基因與聚乙烯亞胺 (PEI) 混合物的製備 31
     五、藥物的製備 32
     六、海馬迴CA1區域注射 33
     第四節 西方墨點法 33
     一、蛋白質萃取 33
     二、蛋白質濃度測定法 34
     三、免疫沉澱 34
     四、西方墨點法 35
     第五節 即時定量聚合酶連鎖反應 36
     第六節 免疫組織化學染色 37
     一、組織切片的製備 37
     二、免疫組織化學染色 38
     第七節 統計分析 38
     第三章 實驗結果 40
     第一節 水迷津試驗降低海馬迴CA1區域Laminin β1 mRNA及蛋白質的表現 41
     第二節 抑制海馬迴CA1區域Laminin β1的表現會促進空間記憶的形成 46
     第三節 轉染野生型Laminin β1質體海馬迴CA1區域會抑制水迷津空間記憶的形成 51
     第四節 抑制海馬迴CA1區域Laminin β1的表現會增加ERK1/2及SGK Ser422的磷酸化 55
     第五節 轉染野生型Laminin β1質體至海馬迴CA1區域會抑制ERK1/2及SGK Ser422的磷酸化 57
     第六節 抑制海馬迴CA1區域SGK1的表現會回復Laminin β1下降所造成空間記憶促進的能力 59
     第七節 抑制海馬迴CA1區域MAPK/ERK的活化會回復Laminin β1 siRNA所促進空間學習記憶的形成，同時阻斷Laminin β1將訊息傳遞至SGK1 64
     第四章 討論 69
     第五章 結論 81
     第六章 參考資料 83
     第七章 附錄 97
     附錄一 98
     附錄二 99
     附錄三 100
     附錄四 103
     附錄五 104
     附錄六 105
     附錄七 106		zh_TW
dc.source.uri (資料來源) http://thesis.lib.nccu.edu.tw/record/#G0096754005en_US
dc.subject (關鍵詞) 學習與記憶zh_TW
dc.subject (關鍵詞) 層黏蛋白zh_TW
dc.subject (關鍵詞) SGKen_US
dc.subject (關鍵詞) Laminin B1en_US
dc.title (題名) Laminin B1抑制ERK1/2及SGK1的活化進而抑制大白鼠空間記憶的形成zh_TW
dc.title (題名) Laminin B1 impairs spatial memry formation in rats through inhibition of ERK1/2 and SGK1 activityen_US
dc.type (資料類型) thesisen_US
dc.relation.reference (參考文獻) Abdallah B, Hassan A, Benoist C, Goula D, Behr JP, Demeneix BA (1996) A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum Gene Ther 7:1947-1954.
     Adams JP, Sweatt JD (2002) Molecular psychology: roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol 42:135-163.
     Adriani W, Leo D, Guarino M, Natoli A, Di Consiglio E, De Angelis G, Traina E, Testai E, Perrone-Capano C, Laviola G (2006) Short-term effects of adolescent methylphenidate exposure on brain striatal gene expression and sexual/endocrine parameters in male rats. Ann N Y Acad Sci 1074:52-73.
     Amaral DG, Witter MP (1989) The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience 31:571-591.
     Amet LE, Lauri SE, Hienola A, Croll SD, Lu Y, Levorse JM, Prabhakaran B, Taira T, Rauvala H, Vogt TF (2001) Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule. Mol Cell Neurosci 17:1014-1024.
     Arbabi S, Maier RV (2002) Mitogen-activated protein kinases. Crit Care Med 30:S74-S79.
     Atkins CM, Selcher JC, Petraitis JJ, Trzaskos JM, Sweatt JD (1998) The MAPK cascade is required for mammalian associative learning. Nat Neurosci 1:602-609.
     Bahr BA, Staubli U, Xiao P, Chun D, Ji ZX, Esteban ET, Lynch G (1997) Arg-Gly-Asp-Ser-selective adhesion and the stabilization of long-term potentiation: pharmacological studies and the characterization of a candidate matrix receptor. J Neurosci 17:1320-1329.
     Becker CG, Artola A, Gerardy-Schahn R, Becker T, Welzl H, Schachner M (1996) The polysialic acid modification of the neural cell adhesion molecule is involved in spatial learning and hippocampal long-term potentiation. J Neurosci Res 45:143-152.
     Bell LM, Leong ML, Kim B, Wang E, Park J, Hemmings BA, Firestone GL (2000) Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK- dependent pathway. J Biol Chem 275:25262-25272.
     Bird CM, Burgess N (2008) The hippocampus and memory: insights from spatial processing. Nat Rev Neurosci 9:182-194.
     Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
     Blum S, Moore AN, Adams F, Dash PK (1999) A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory. J Neurosci 19:3535-3544.
     Boletta A, Benigni A, Lutz J, Remuzzi G, Soria MR, Monaco L (1997) Nonviral gene delivery to the rat kidney with polyethylenimine. Hum Gene Ther 8:1243-1251.
     Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD (1991) ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65:663-675.
     Bovet D, Bovet-Nitti F, Oliverio A (1968) Memory and consolidation mechanisms in avoidance learning of inbred mice. Brain Res 10:168-182.
     Burgeson RE, Chiquet M, Deutzmann R, Ekblom P, Engel J, Kleinman H, Martin GR, Meneguzzi G, Paulsson M, Sanes J, et al. (1994) A new nomenclature for the laminins. Matrix Biol 14:209-211.
     Burwell RD, Witter MP, Amaral DG (1995) Perirhinal and postrhinal cortices of the rat: a review of the neuroanatomical literature and comparison with findings from the monkey brain. Hippocampus 5:390-408.
     Calof AL, Campanero MR, O`Rear JJ, Yurchenco PD, Lander AD (1994) Domain-specific activation of neuronal migration and neurite outgrowth-promoting activities of laminin. Neuron 13:117-130.
     Castren E, Pitkanen M, Sirvio J, Parsadanian A, Lindholm D, Thoenen H, Riekkinen PJ (1993) The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus. Neuroreport 4:895-898.
     Chan CS, Weeber EJ, Kurup S, Sweatt JD, Davis RL (2003) Integrin requirement for hippocampal synaptic plasticity and spatial memory. J Neurosci 23:7107-7116.
     Chan CS, Weeber EJ, Zong L, Fuchs E, Sweatt JD, Davis RL (2006) Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory. J Neurosci 26:223-232.
     Chan CS, Levenson JM, Mukhopadhyay PS, Zong L, Bradley A, Sweatt JD, Davis RL (2007) Alpha3-integrins are required for hippocampal long-term potentiation and working memory. Learn Mem 14:606- 615.
     Chao CC, Ma YL, Lee EH (2007) Protein kinase CK2 impairs spatial memory formation through differential cross talk with PI-3 kinase signaling: activation of Akt and inactivation of SGK1. J Neurosci 27:6243-6248.
     Chen SY, Bhargava A, Mastroberardino L, Meijer OC, Wang J, Buse P, Firestone GL, Verrey F, Pearce D (1999) Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc Natl Acad Sci U S A 96:2514-2519.
     Chen ZL, Indyk JA, Strickland S (2003) The hippocampal laminin matrix is dynamic and critical for neuronal survival. Mol Biol Cell 14:2665- 2676.
     Cheng YS, Champliaud MF, Burgeson RE, Marinkovich MP, Yurchenco PD (1997) Self-assembly of laminin isoforms. J Biol Chem 272: 31525-31532.
     Chun SJ, Rasband MN, Sidman RL, Habib AA, Vartanian T (2003) Integrin-linked kinase is required for laminin-2-induced oligo- dendrocyte cell spreading and CNS myelination. J Cell Biol 163: 397-408.
     Coccia EM, Del Russo N, Stellacci E, Testa U, Marziali G, Battistini A (1999) STAT1 activation during monocyte to macrophage maturation: role of adhesion molecules. Int Immunol 11:1075-1083.
     Coitinho AS, Freitas AR, Lopes MH, Hajj GN, Roesler R, Walz R, Rossato JI, Cammarota M, Izquierdo I, Martins VR, Brentani RR (2006) The interaction between prion protein and laminin modulates memory consolidation. Eur J Neurosci 24:3255-3264.
     Coogan AN, O`Leary DM, O`Connor JJ (1999) P42/44 MAP kinase inhibitor PD98059 attenuates multiple forms of synaptic plasticity in rat dentate gyrus in vitro. J Neurophysiol 81:103-110.
     D`Arcangelo G (2005) Apoer2: a reelin receptor to remember. Neuron 47: 471-473.
     David S, Kalb RG (2005) Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB. FEBS Lett 579:1534-1538.
     Davis HP, Spanis CW, Squire LR (1976) Inhibition of cerebral protein synthesis: performance at different times after passive avoidance training. Pharmacol Biochem Behav 4:13-16.
     Davis HP, Rosenzweig MR, Grove EA, Bennett EL (1984) Investigation of the reported protective effect of cycloheximide on memory. Pharmacol Biochem Behav 20:405-413.
     Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Munster C, Chraibi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O (2001) Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J 20: 7052-7059.
     Delwel GO, Hogervorst F, Sonnenberg A (1996) Cleavage of the alpha6A subunit is essential for activation of the alpha6Abeta1 integrin by phorbol 12-myristate 13-acetate. J Biol Chem 271:7293-7296.
     Durbeej M (2009) Laminins. Cell Tissue Res.
     Evers MR, Salmen B, Bukalo O, Rollenhagen A, Bosl MR, Morellini F, Bartsch U, Dityatev A, Schachner M (2002) Impairment of L-type Ca2+ channel-dependent forms of hippocampal synaptic plasticity in mice deficient in the extracellular matrix glycoprotein tenascin-C. J Neurosci 22:7177-7194.
     Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623 -18632.
     Firestone GL, Giampaolo JR, O`Keeffe BA (2003) Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell Physiol Biochem 13:1-12.
     Fukazawa Y, Saitoh Y, Ozawa F, Ohta Y, Mizuno K, Inokuchi K (2003) Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. Neuron 38:447-460.
     Goelet P, Castellucci VF, Schacher S, Kandel ER (1986) The long and the short of long-term memory--a molecular framework. Nature 322: 419- 422.
     Grewal SS, York RD, Stork PJ (1999) Extracellular-signal-regulated kinase signalling in neurons. Curr Opin Neurobiol 9:544-553.
     Gruenbaum LM, Carew TJ (1999) Growth factor modulation of substrate-specific morphological patterns in Aplysia bag cell neurons. Learn Mem 6:292-306.
     Gubler MC (2008) Inherited diseases of the glomerular basement membrane. Nat Clin Pract Nephrol 4:24-37.
     Hebb DO (1949) The organization of behavior, Wiley, New York.
     Henry MD, Campbell KP (1996) Dystroglycan: an extracellular matrix receptor linked to the cytoskeleton. Curr Opin Cell Biol 8:625-631.
     Hoffman KB, Martinez J, Lynch G (1998) Proteolysis of cell adhesion molecules by serine proteases: a role in long term potentiation? Brain Res 811:29-33.
     Hollister RD, Page KJ, Hyman BT (1997) Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: effects of excitotoxic hippocampal lesions. Neuroscience 79: 1111- 1119.
     Horwood JM, Dufour F, Laroche S, Davis S (2006) Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. Eur J Neurosci 23:3375-3384.
     Hsu WL, Chiu TH, Tai DJ, Ma YL, Lee EH (2009) A novel defense mechanism that is activated on amyloid-beta insult to mediate cell survival: role of SGK1-STAT1/STAT2 signaling. Cell Death Differ 16:1515-1529.
     Huang Z, Shimazu K, Woo NH, Zang K, Muller U, Lu B, Reichardt LF (2006) Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse. J Neurosci 26:11208-11219.
     Indyk JA, Chen ZL, Tsirka SE, Strickland S (2003) Laminin chain expression suggests that laminin-10 is a major isoform in the mouse hippocampus and is degraded by the tissue plasminogen activator/plasmin protease cascade during excitotoxic injury. Neuroscience 116:359-371.
     Ishizuka N, Cowan WM, Amaral DG (1995) A quantitative analysis of the dendritic organization of pyramidal cells in the rat hippocampus. J Comp Neurol 362:17-45.
     Jones PL, Jones FS (2000) Tenascin-C in development and disease: gene regulation and cell function. Matrix Biol 19:581-596.
     Kesner RP, Hardy JD (1983) Long-term memory for contextual attributes: dissociation of amygdala and hippocampus. Behav Brain Res 8:139-149.
     Kiernan BW, Garcion E, Ferguson J, Frost EE, Torres EM, Dunnett SB, Saga Y, Aizawa S, Faissner A, Kaur R, Franklin RJ, ffrench- Constant C (1999) Myelination and behaviour of tenascin-C null transgenic mice. Eur J Neurosci 11:3082-3092.
     Kobayashi T, Cohen P (1999) Activation of serum- and glucocorticoid- regulated protein kinase by agonists that activate phosphatidy- linositide 3-kinase is mediated by 3-phosphoinositide -dependent protein kinase-1 (PDK1) and PDK2. Biochem J 339 ( Pt 2):319-328.
     Kobayashi T, Deak M, Morrice N, Cohen P (1999) Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Biochem J 344 Pt 1:189-197.
     Korte M, Staiger V, Griesbeck O, Thoenen H, Bonhoeffer T (1996) The involvement of brain-derived neurotrophic factor in hippocampal long-term potentiation revealed by gene targeting experiments. J Physiol Paris 90:157-164.
     Kramar EA, Bernard JA, Gall CM, Lynch G (2002) Alpha3 integrin receptors contribute to the consolidation of long-term potentiation. Neuroscience 110:29-39.
     Krucker T, Siggins GR, Halpain S (2000) Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus. Proc Natl Acad Sci U S A 97:6856-6861.
     Lacourse MG, Orr EL, Cramer SC, Cohen MJ (2005) Brain activation during execution and motor imagery of novel and skilled sequential hand movements. Neuroimage 27:505-519.
     Lang F, Cohen P (2001) Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci STKE 2001: RE17.
     Lauri SE, Kaukinen S, Kinnunen T, Ylinen A, Imai S, Kaila K, Taira T, Rauvala H (1999) Reg1ulatory role and molecular interactions of a cell-surface heparan sulfate proteoglycan (N-syndecan) in hippocampal long-term potentiation. J Neurosci 19:1226-1235.
     Lee CT, Tyan SW, Ma YL, Tsai MC, Yang YC, Lee EH (2006) Serum- and glucocorticoid-inducible kinase (SGK) is a target of the MAPK/ERK signaling pathway that mediates memory formation in rats. Eur J Neurosci 23:1311-1320.
     Lee EH, Hsu WL, Ma YL, Lee PJ, Chao CC (2003) Enrichment enhances the expression of sgk, a glucocorticoid-induced gene, and facilitates spatial learning through glutamate AMPA receptor mediation. Eur J Neurosci 18:2842-2852.
     Legate KR, Wickstrom SA, Fassler R (2009) Genetic and cell biological analysis of integrin outside-in signaling. Genes Dev 23:397-418.
     Leong ML, Maiyar AC, Kim B, O`Keeffe BA, Firestone GL (2003) Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J Biol Chem 278:5871-5882.
     Libby RT, Lavallee CR, Balkema GW, Brunken WJ, Hunter DD (1999) Disruption of laminin beta2 chain production causes alterations in morphology and function in the CNS. J Neurosci 19:9399-9411.
     Liesi P, Dahl D, Vaheri A (1983) Laminin is produced by early rat astrocytes in primary culture. J Cell Biol 96:920-924.
     Liesi P, Fried G, Stewart RR (2001) Neurons and glial cells of the embryonic human brain and spinal cord express multiple and distinct isoforms of laminin. J Neurosci Res 64:144-167.
     Liu SJ, Zhang AH, Li HL, Wang Q, Deng HM, Netzer WJ, Xu H, Wang JZ (2003) Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. J Neurochem 87:1333-1344.
     Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408.
     Lopez-Colome AM, Ortega A (1997) Activation of p42 mitogen-activated protein kinase by glutamate in cultured radial glia. Neurochem Res 22:679-685.
     Luthl A, Laurent JP, Figurov A, Muller D, Schachner M (1994) Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM. Nature 372:777-779.
     Ma YL, Tsai MC, Hsu WL, Lee EH (2006) SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons. Learn Mem 13:114-118.
     Maiyar AC, Phu PT, Huang AJ, Firestone GL (1997) Repression of glucocorticoid receptor transactivation and DNA binding of a glucocorticoid response element within the serum/ glucocorticoid -inducible protein kinase (sgk) gene promoter by the p53 tumor suppressor protein. Mol Endocrinol 11:312-329.
     Maiyar AC, Huang AJ, Phu PT, Cha HH, Firestone GL (1996) p53 stimulates promoter activity of the sgk. serum/glucocorticoid -inducible serine/threonine protein kinase gene in rodent mammary epithelial cells. J Biol Chem 271:12414-12422.
     Mazzucchelli C, Vantaggiato C, Ciamei A, Fasano S, Pakhotin P, Krezel W, Welzl H, Wolfer DP, Pages G, Valverde O, Marowsky A, Porrazzo A, Orban PC, Maldonado R, Ehrengruber MU, Cestari V, Lipp HP, Chapman PF, Pouyssegur J, Brambilla R (2002) Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron 34: 807- 820.
     McGaugh JL, Cahill L, Roozendaal B (1996) Involvement of the amygdala in memory storage: interaction with other brain systems. Proc Natl Acad Sci U S A 93:13508-13514.
     McNaughton BL, Barnes CA, Meltzer J, Sutherland RJ (1989) Hippocampal granule cells are necessary for normal spatial learning but not for spatially-selective pyramidal cell discharge. Exp Brain Res 76:485-496.
     Meighan SE, Meighan PC, Choudhury P, Davis CJ, Olson ML, Zornes PA, Wright JW, Harding JW (2006) Effects of extracellular matrix- degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticity. J Neurochem 96:1227-1241.
     Milner B, Squire LR, Kandel ER (1998) Cognitive neuroscience and the study of memory. Neuron 20:445-468.
     Miner JH (2008) Laminins and their roles in mammals. Microsc Res Tech 71:349-356.
     Miner JH, Patton BL, Lentz SI, Gilbert DJ, Snider WD, Jenkins NA, Copeland NG, Sanes JR (1997) The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. J Cell Biol 137:685-701.
     Mizuno H, Nishida E (2001) The ERK MAP kinase pathway mediates induction of SGK (serum- and glucocorticoid-inducible kinase) by growth factors. Genes Cells 6:261-268.
     Mizuno M, Yamada K, He J, Nakajima A, Nabeshima T (2003) Involvement of BDNF receptor TrkB in spatial memory formation. Learn Mem 10:108-115.
     Moore SA, Saito F, Chen J, Michele DE, Henry MD, Messing A, Cohn RD, Ross-Barta SE, Westra S, Williamson RA, Hoshi T, Campbell KP (2002) Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. Nature 418:422-425.
     Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47-60.
     Moser E, Moser MB, Andersen P (1993) Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J Neurosci 13:3916-3925.
     Moser MB, Moser EI, Forrest E, Andersen P, Morris RG (1995) Spatial learning with a minislab in the dorsal hippocampus. Proc Natl Acad Sci U S A 92:9697-9701.
     Muller D, Wang C, Skibo G, Toni N, Cremer H, Calaora V, Rougon G, Kiss JZ (1996) PSA-NCAM is required for activity-induced synaptic plasticity. Neuron 17:413-422.
     Nakagami Y, Abe K, Nishiyama N, Matsuki N (2000) Laminin degradation by plasmin regulates long-term potentiation. J Neurosci 20: 2003- 2010.
     Noakes PG, Miner JH, Gautam M, Cunningham JM, Sanes JR, Merlie JP (1995) The renal glomerulus of mice lacking s-laminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1. Nat Genet 10:400-406.
     O`Keefe J, Dostrovsky J (1971) The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res 34:171-175.
     Oitzl MS, Reichardt HM, Joels M, de Kloet ER (2001) Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory. Proc Natl Acad Sci U S A 98:12790-12795.
     Packard MG, Hirsh R, White NM (1989) Differential effects of fornix and caudate nucleus lesions on two radial maze tasks: evidence for multiple memory systems. J Neurosci 9:1465-1472.
     Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA (1999) Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 18:3024-3033.
     Parsons MJ, Pollard SM, Saude L, Feldman B, Coutinho P, Hirst EM, Stemple DL (2002) Zebrafish mutants identify an essential role for laminins in notochord formation. Development 129:3137-3146.
     Patterson SL, Grover LM, Schwartzkroin PA, Bothwell M (1992) Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9:1081-1088.
     Patton BL (2000) Laminins of the neuromuscular system. Microsc Res Tech 51:247-261.
     Patton BL, Miner JH, Chiu AY, Sanes JR (1997) Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice. J Cell Biol 139:1507-1521.
     Pavlov I, Voikar V, Kaksonen M, Lauri SE, Hienola A, Taira T, Rauvala H (2002) Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice. Mol Cell Neurosci 20:330-342.
     Paxinos G, Watson CR, Emson PC (1980) AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. J Neurosci Methods 3:129-149.
     Richards JS, Fitzpatrick SL, Clemens JW, Morris JK, Alliston T, Sirois J (1995) Ovarian cell differentiation: a cascade of multiple hormones, cellular signals, and regulated genes. Recent Prog Horm Res 50:223-254.
     Roozendaal B, Portillo-Marquez G, McGaugh JL (1996) Basolateral amygdala lesions block glucocorticoid-induced modulation of memory for spatial learning. Behav Neurosci 110:1074-1083.
     Rousse I, Beaulieu S, Rowe W, Meaney MJ, Barden N, Rochford J (1997) Spatial memory in transgenic mice with impaired glucocorticoid receptor function. Neuroreport 8:841-845.
     Sandi C, Merino JJ, Cordero MI, Kruyt ND, Murphy KJ, Regan CM (2003) Modulation of hippocampal NCAM polysialylation and spatial memory consolidation by fear conditioning. Biol Psychiatry 54:599-607.
     Sandi C, Cordero MI, Merino JJ, Kruyt ND, Regan CM, Murphy KJ (2004) Neurobiological and endocrine correlates of individual differences in spatial learning ability. Learn Mem 11:244-252.
     Sarazin M, Deweer B, Merkl A, Von Poser N, Pillon B, Dubois B (2002) Procedural learning and striatofrontal dysfunction in Parkinson`s disease. Mov Disord 17:265-273.
     Schlaepfer DD, Hunter T (1998) Integrin signalling and tyrosine phosphorylation: just the FAKs? Trends Cell Biol 8:151-157.
     Schubert D (1991) The possible role of adhesion in synaptic modification. Trends Neurosci 14:127-130.
     Scoville WB, Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20:11-21.
     Selcher JC, Atkins CM, Trzaskos JM, Paylor R, Sweatt JD (1999) A necessity for MAP kinase activation in mammalian spatial learning. Learn Mem 6:478-490.
     Selcher JC, Weeber EJ, Christian J, Nekrasova T, Landreth GE, Sweatt JD (2003) A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1. Learn Mem 10:26-39.
     Sharif KA, Baker H, Gudas LJ (2004a) Differential regulation of laminin b1 transgene expression in the neonatal and adult mouse brain. Neuroscience 126:967-978.
     Sharif KA, Baker H, Gudas LJ (2004b) Differential regulation of laminin b1 transgene expression in the neonatal and adult mouse brain. In: Neuroscience, 2004/06/23 Edition, pp 967-978.
     Staubli U, Chun D, Lynch G (1998) Time-dependent reversal of long-term potentiation by an integrin antagonist. J Neurosci 18:3460-3469.
     Sunada Y, Bernier SM, Kozak CA, Yamada Y, Campbell KP (1994) Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus. J Biol Chem 269:13729-13732.
     Tai DJ, Su CC, Ma YL, Lee EH (2009) SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression. J Biol Chem 284:4073-4089.
     Talts JF, Andac Z, Gohring W, Brancaccio A, Timpl R (1999) Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins. EMBO J 18:863-870.
     Thomas KL, Hunt SP (1993) The regional distribution of extracellularly regulated kinase-1 and -2 messenger RNA in the adult rat central nervous system. Neuroscience 56:741-757.
     Thompson RF, Krupa DJ (1994) Organization of memory traces in the mammalian brain. Annu Rev Neurosci 17:519-549.
     Timpl R, Rohde H, Robey PG, Rennard SI, Foidart JM, Martin GR (1979) Laminin--a glycoprotein from basement membranes. J Biol Chem 254:9933-9937.
     Tsai KJ, Chen SK, Ma YL, Hsu WL, Lee EH (2002) sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats. Proc Natl Acad Sci U S A 99:3990-3995.
     Tunggal P, Smyth N, Paulsson M, Ott MC (2000) Laminins: structure and genetic regulation. Microsc Res Tech 51:214-227.
     Tyan SW, Tsai MC, Lin CL, Ma YL, Lee EH (2008) Serum- and glucocorticoid-inducible kinase 1 enhances zif268 expression through the mediation of SRF and CREB1 associated with spatial memory formation. J Neurochem 105:820-832.
     Venero C, Herrero AI, Touyarot K, Cambon K, Lopez-Fernandez MA, Berezin V, Bock E, Sandi C (2006) Hippocampal up-regulation of NCAM expression and polysialylation plays a key role on spatial memory. Eur J Neurosci 23:1585-1595.
     Waldegger S, Gabrysch S, Barth P, Fillon S, Lang F (2000) h-sgk serine-threonine protein kinase as transcriptional target of p38/MAP kinase pathway in HepG2 human hepatoma cells. Cell Physiol Biochem 10:203-208.
     Waldegger S, Klingel K, Barth P, Sauter M, Rfer ML, Kandolf R, Lang F (1999) h-sgk serine-threonine protein kinase gene as transcriptional target of transforming growth factor beta in human intestine. Gastroenterology 116:1081-1088.
     Warrington EK, Weiskrantz L (1968) New method of testing long-term retention with special reference to amnesic patients. Nature 217:972-974.
     Webster MK, Goya L, Firestone GL (1993a) Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine/threonine protein kinase. J Biol Chem 268:11482-11485.
     Webster MK, Goya L, Ge Y, Maiyar AC, Firestone GL (1993b) Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol Cell Biol 13:2031-2040.
     Weeber EJ, Beffert U, Jones C, Christian JM, Forster E, Sweatt JD, Herz J (2002) Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem 277: 39944-39952.
     Wiksten M, Vaananen AJ, Liebkind R, Liesi P (2004a) Regeneration of adult rat spinal cord is promoted by the soluble KDI domain of gamma1 laminin. J Neurosci Res 78:403-410.
     Wiksten M, Vaananen A, Liebkind R, Rauhala P, Liesi P (2004b) Soluble KDI domain of gamma1 laminin protects adult hippocampus from excitotoxicity of kainic acid. J Neurosci Res 78:411-419.
     Wright JW, Kramar EA, Meighan SE, Harding JW (2002) Extracellular matrix molecules, long-term potentiation, memory consolidation and the brain angiotensin system. Peptides 23:221-246.
     Wu W, Chaudhuri S, Brickley DR, Pang D, Karrison T, Conzen SD (2004) Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res 64:1757-1764.
     Yang YC, Lin CH, Lee EH (2006) Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau. Mol Cell Biol 26:8357-8370.
     Yin Y, Kikkawa Y, Mudd JL, Skarnes WC, Sanes JR, Miner JH (2003) Expression of laminin chains by central neurons: analysis with gene and protein trapping techniques. Genesis 36:114-127.
     Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22:1532-1540.
     Yurchenco PD, Cheng YS (1994) Laminin self-assembly: a three-arm interaction hypothesis for the formation of a network in basement membranes. Contrib Nephrol 107:47-56.
     Zaccaria ML, Di Tommaso F, Brancaccio A, Paggi P, Petrucci TC (2001) Dystroglycan distribution in adult mouse brain: a light and electron microscopy study. Neuroscience 104:311-324.
     Zhang BH, Tang ED, Zhu T, Greenberg ME, Vojtek AB, Guan KL (2001) Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. J Biol Chem 276:31620-31626.
     Zhou R, Snyder PM (2005) Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation. J Biol Chem 280:4518-4523.
     Zhou XH, Brakebusch C, Matthies H, Oohashi T, Hirsch E, Moser M, Krug M, Seidenbecher CI, Boeckers TM, Rauch U, Buettner R, Gundelfinger ED, Fassler R (2001) Neurocan is dispensable for brain development. Mol Cell Biol 21:5970-5978.		zh_TW