| dc.contributor | 神科所 | |
| dc.creator (作者) | 趙知章 | zh_TW |
| dc.creator (作者) | CC, Chao;EHY, Lee | |
| dc.date (日期) | 1999 | |
| dc.date.accessioned | 13-Jul-2016 14:31:13 (UTC+8) | - |
| dc.date.available | 13-Jul-2016 14:31:13 (UTC+8) | - |
| dc.date.issued (上傳時間) | 13-Jul-2016 14:31:13 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/99016 | - |
| dc.description.abstract (摘要) | Recombinant human GDNF was infused into the rat striatum either acutely or subchronically. Its effects and its interactions with MPP+ on antioxidant enzyme activities were examined. Results indicated that acute GDNF infusion significantly increased glutathione peroxidase, superoxide dismutase and catalase activities. Subchronic GDNF treatment decreased the DA level and enhanced DA turnover. Pre-treatment with GDNF markedly protected DA neurons against MPP+-induced toxicity. These results suggest that GDNF protects DA neurons through its activation of the antioxidant enzyme systems. | |
| dc.format.extent | 56026 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | Neuropharmacol., 38(6), 913-916 | |
| dc.subject (關鍵詞) | Glial cell line-derived neurotrophic factor; Glutathione peroxidase; Superoxide dismutase; Catalase; Dopamine; 1-Methyl-4-phenylpyridinium | |
| dc.title (題名) | Neuroprotective mechanism of glial cell line-derived neurotrophic factor on dopamine neurons: effects on antioxidation. | |
| dc.type (資料類型) | article | |
| dc.identifier.doi (DOI) | 10.1016/S0028-3908(99)00030-1 | |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1016/S0028-3908(99)00030-1 | |
