| dc.contributor | 神科所 | |
| dc.creator (作者) | 詹銘煥 | zh_TW |
| dc.creator (作者) | Lin, Jen-Cheng;Lee, Mei-Yi;Chan, Ming-Huan;Chen, Yi-Chyan;Chen, Hwei-Hsien | |
| dc.date (日期) | 2016-09 | |
| dc.date.accessioned | 5-Jun-2017 14:45:04 (UTC+8) | - |
| dc.date.available | 5-Jun-2017 14:45:04 (UTC+8) | - |
| dc.date.issued (上傳時間) | 5-Jun-2017 14:45:04 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/110181 | - |
| dc.description.abstract (摘要) | Ketamine is emerging as a new hope against depression, but ketamine-associated psychotomimetic effects limit its clinical use. An adjunct therapy along with ketamine to alleviate its adverse effects and even potentiate the antidepressant effects might be an alternative strategy. Betaine, a methyl derivative of glycine and a dietary supplement, has been shown to have antidepressant-like effects and to act like a partial agonist at the glycine site of N-methyl-D-aspartate receptors (NMDARs). Accordingly, betaine might have potential to be an adjunct to ketamine treatment for depression. The antidepressant-like effects of ketamine and betaine were evaluated by forced swimming test and novelty suppressed feeding test in mice. Both betaine and ketamine produced antidepressant-like effects. Furthermore, we determined the effects of betaine on ketamine-induced antidepressant-like and psychotomimetic behaviors, motor incoordination, hyperlocomotor activity, and anesthesia. The antidepressant-like responses to betaine combined with ketamine were stronger than their individual effects. In contrast, ketamine-induced impairments in prepulse inhibition, novel object recognition test, social interaction, and rotarod test were remarkably attenuated, whereas ketamine-induced hyperlocomotion and loss of righting reflex were not affected by betaine. These findings revealed that betaine could enhance the antidepressant-like effects, yet block the psychotomimetic effects of ketamine, suggesting that betaine can be considered as an add-on therapy to ketamine for treatment-resistant depression and suitable for the treatment of depressive symptoms in patients with schizophrenia. | |
| dc.format.extent | 659600 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | Psychopharmacology, Vol.233, Issue 17, pp.3223-35 | |
| dc.subject (關鍵詞) | Behavior ; NMDA receptor ; Depression ; Schizophrenia ; Prepulse inhibition | |
| dc.title (題名) | Betaine enhances antidepressant-like, but blocks psychotomimetic effects of ketamine in mice | |
| dc.type (資料類型) | article | |
| dc.identifier.doi (DOI) | 10.1007/s00213-016-4359-x | |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1007/s00213-016-4359-x | |
