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題名 1H MR spectroscopy in cervical carcinoma using external phase array body coil at 3.0 Tesla: Prediction of poor prognostic human papillomavirus genotypes
作者 Lin, Gigin;Ng, Koon‐Kwan;Ng, Shu‐Hang
蔡尚岳
Lai, Chyong‐Huey
Tsai, Shang‐Yueh
Lin, Yu‐Chun
Huang, Yu‐Ting
Wu, Ren‐Chin
Yang, Lan‐Yan
Lu, Hsin‐Ying
Chao, Angel
Wang, Chiun‐Chieh
Hung, Ji‐Hong
Yen, Tzu‐Chen
Chou, Hung‐Hsueh
貢獻者 應物所
日期 2017
上傳時間 19-Jul-2017 16:26:20 (UTC+8)
摘要 Purpose: To assess the clinical value of proton (1H) MR spectroscopy in cervical carcinomas, in the prediction of poor prognostic human papillomavirus (HPV) genotypes as well as persistent disease following concurrent chemoradiotherapy (CCRT). Materials and Methods: 1H MR spectroscopy using external phase array coil was performed in 52 consecutive cervical cancer patients at 3 Tesla (T). Poor prognostic HPV genotypes (alpha-7 species or absence of HPV infection) and persistent cervical carcinoma after CCRT were recorded. Statistical significance was calculated with the Mann-Whitney two-sided nonparametric test and areas under the receiver operating characteristics curve (AUC) analysis. Results: A 4.3-fold (P = 0.032) increased level of methyl resonance at 0.9 ppm was found in the poor prognostic HPV genotypes, mainly attributed to the presence of HPV18, with a sensitivity of 75%, a specificity of 81%, and an AUC of 0.76. Poor prognostic HPV genotypes were more frequently observed in patients with adeno-/adenosquamous carcinoma (Chi-square, P < 0.0001). In prediction of the four patients with persistent disease after CCRT, elevated methyl resonance demonstrated a sensitivity of 100%, a specificity of 74%, and an AUC of 0.82. Conclusion: 1H MR spectroscopy at 3T can be used to depict the elevated lipid resonance levels in cervical carcinomas, as well as help to predict the poor prognostic HPV genotypes and persistent disease following CCRT. Further large studies with longer follow up times are warranted to validate our initial findings. Level of Evidence: 1. J. Magn. Reson. Imaging 2017;45:899–907. © 2016 International Society for Magnetic Resonance in Medicine
關聯 Journal of Magnetic Resonance Imaging, 45(3), 899-907
資料類型 article
DOI http://dx.doi.org/10.1002/jmri.25386
dc.contributor 應物所-
dc.creator (作者) Lin, Gigin;Ng, Koon‐Kwan;Ng, Shu‐Hangen-US
dc.creator (作者) 蔡尚岳zh-tw
dc.creator (作者) Lai, Chyong‐Hueyen_US
dc.creator (作者) Tsai, Shang‐Yuehen_US
dc.creator (作者) Lin, Yu‐Chunen_US
dc.creator (作者) Huang, Yu‐Tingen_US
dc.creator (作者) Wu, Ren‐Chinen_US
dc.creator (作者) Yang, Lan‐Yanen_US
dc.creator (作者) Lu, Hsin‐Yingen_US
dc.creator (作者) Chao, Angelen_US
dc.creator (作者) Wang, Chiun‐Chiehen_US
dc.creator (作者) Hung, Ji‐Hongen_US
dc.creator (作者) Yen, Tzu‐Chenen_US
dc.creator (作者) Chou, Hung‐Hsuehen_US
dc.date (日期) 2017-
dc.date.accessioned 19-Jul-2017 16:26:20 (UTC+8)-
dc.date.available 19-Jul-2017 16:26:20 (UTC+8)-
dc.date.issued (上傳時間) 19-Jul-2017 16:26:20 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/111257-
dc.description.abstract (摘要) Purpose: To assess the clinical value of proton (1H) MR spectroscopy in cervical carcinomas, in the prediction of poor prognostic human papillomavirus (HPV) genotypes as well as persistent disease following concurrent chemoradiotherapy (CCRT). Materials and Methods: 1H MR spectroscopy using external phase array coil was performed in 52 consecutive cervical cancer patients at 3 Tesla (T). Poor prognostic HPV genotypes (alpha-7 species or absence of HPV infection) and persistent cervical carcinoma after CCRT were recorded. Statistical significance was calculated with the Mann-Whitney two-sided nonparametric test and areas under the receiver operating characteristics curve (AUC) analysis. Results: A 4.3-fold (P = 0.032) increased level of methyl resonance at 0.9 ppm was found in the poor prognostic HPV genotypes, mainly attributed to the presence of HPV18, with a sensitivity of 75%, a specificity of 81%, and an AUC of 0.76. Poor prognostic HPV genotypes were more frequently observed in patients with adeno-/adenosquamous carcinoma (Chi-square, P < 0.0001). In prediction of the four patients with persistent disease after CCRT, elevated methyl resonance demonstrated a sensitivity of 100%, a specificity of 74%, and an AUC of 0.82. Conclusion: 1H MR spectroscopy at 3T can be used to depict the elevated lipid resonance levels in cervical carcinomas, as well as help to predict the poor prognostic HPV genotypes and persistent disease following CCRT. Further large studies with longer follow up times are warranted to validate our initial findings. Level of Evidence: 1. J. Magn. Reson. Imaging 2017;45:899–907. © 2016 International Society for Magnetic Resonance in Medicine-
dc.format.extent 108 bytes-
dc.format.mimetype text/html-
dc.relation (關聯) Journal of Magnetic Resonance Imaging, 45(3), 899-907-
dc.title (題名) 1H MR spectroscopy in cervical carcinoma using external phase array body coil at 3.0 Tesla: Prediction of poor prognostic human papillomavirus genotypesen-US
dc.type (資料類型) article-
dc.identifier.doi (DOI) 10.1002/jmri.25386-
dc.doi.uri (DOI) http://dx.doi.org/10.1002/jmri.25386-