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題名 1H MR spectroscopy in cervical carcinoma using external phase array body coil at 3.0 Tesla: Prediction of poor prognostic human papillomavirus genotypes 作者 Lin, Gigin;Ng, Koon‐Kwan;Ng, Shu‐Hang
蔡尚岳
Lai, Chyong‐Huey
Tsai, Shang‐Yueh
Lin, Yu‐Chun
Huang, Yu‐Ting
Wu, Ren‐Chin
Yang, Lan‐Yan
Lu, Hsin‐Ying
Chao, Angel
Wang, Chiun‐Chieh
Hung, Ji‐Hong
Yen, Tzu‐Chen
Chou, Hung‐Hsueh貢獻者 應物所 日期 2017 上傳時間 19-Jul-2017 16:26:20 (UTC+8) 摘要 Purpose: To assess the clinical value of proton (1H) MR spectroscopy in cervical carcinomas, in the prediction of poor prognostic human papillomavirus (HPV) genotypes as well as persistent disease following concurrent chemoradiotherapy (CCRT). Materials and Methods: 1H MR spectroscopy using external phase array coil was performed in 52 consecutive cervical cancer patients at 3 Tesla (T). Poor prognostic HPV genotypes (alpha-7 species or absence of HPV infection) and persistent cervical carcinoma after CCRT were recorded. Statistical significance was calculated with the Mann-Whitney two-sided nonparametric test and areas under the receiver operating characteristics curve (AUC) analysis. Results: A 4.3-fold (P = 0.032) increased level of methyl resonance at 0.9 ppm was found in the poor prognostic HPV genotypes, mainly attributed to the presence of HPV18, with a sensitivity of 75%, a specificity of 81%, and an AUC of 0.76. Poor prognostic HPV genotypes were more frequently observed in patients with adeno-/adenosquamous carcinoma (Chi-square, P < 0.0001). In prediction of the four patients with persistent disease after CCRT, elevated methyl resonance demonstrated a sensitivity of 100%, a specificity of 74%, and an AUC of 0.82. Conclusion: 1H MR spectroscopy at 3T can be used to depict the elevated lipid resonance levels in cervical carcinomas, as well as help to predict the poor prognostic HPV genotypes and persistent disease following CCRT. Further large studies with longer follow up times are warranted to validate our initial findings. Level of Evidence: 1. J. Magn. Reson. Imaging 2017;45:899–907. © 2016 International Society for Magnetic Resonance in Medicine 關聯 Journal of Magnetic Resonance Imaging, 45(3), 899-907 資料類型 article DOI http://dx.doi.org/10.1002/jmri.25386 dc.contributor 應物所 - dc.creator (作者) Lin, Gigin;Ng, Koon‐Kwan;Ng, Shu‐Hang en-US dc.creator (作者) 蔡尚岳 zh-tw dc.creator (作者) Lai, Chyong‐Huey en_US dc.creator (作者) Tsai, Shang‐Yueh en_US dc.creator (作者) Lin, Yu‐Chun en_US dc.creator (作者) Huang, Yu‐Ting en_US dc.creator (作者) Wu, Ren‐Chin en_US dc.creator (作者) Yang, Lan‐Yan en_US dc.creator (作者) Lu, Hsin‐Ying en_US dc.creator (作者) Chao, Angel en_US dc.creator (作者) Wang, Chiun‐Chieh en_US dc.creator (作者) Hung, Ji‐Hong en_US dc.creator (作者) Yen, Tzu‐Chen en_US dc.creator (作者) Chou, Hung‐Hsueh en_US dc.date (日期) 2017 - dc.date.accessioned 19-Jul-2017 16:26:20 (UTC+8) - dc.date.available 19-Jul-2017 16:26:20 (UTC+8) - dc.date.issued (上傳時間) 19-Jul-2017 16:26:20 (UTC+8) - dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/111257 - dc.description.abstract (摘要) Purpose: To assess the clinical value of proton (1H) MR spectroscopy in cervical carcinomas, in the prediction of poor prognostic human papillomavirus (HPV) genotypes as well as persistent disease following concurrent chemoradiotherapy (CCRT). Materials and Methods: 1H MR spectroscopy using external phase array coil was performed in 52 consecutive cervical cancer patients at 3 Tesla (T). Poor prognostic HPV genotypes (alpha-7 species or absence of HPV infection) and persistent cervical carcinoma after CCRT were recorded. Statistical significance was calculated with the Mann-Whitney two-sided nonparametric test and areas under the receiver operating characteristics curve (AUC) analysis. Results: A 4.3-fold (P = 0.032) increased level of methyl resonance at 0.9 ppm was found in the poor prognostic HPV genotypes, mainly attributed to the presence of HPV18, with a sensitivity of 75%, a specificity of 81%, and an AUC of 0.76. Poor prognostic HPV genotypes were more frequently observed in patients with adeno-/adenosquamous carcinoma (Chi-square, P < 0.0001). In prediction of the four patients with persistent disease after CCRT, elevated methyl resonance demonstrated a sensitivity of 100%, a specificity of 74%, and an AUC of 0.82. Conclusion: 1H MR spectroscopy at 3T can be used to depict the elevated lipid resonance levels in cervical carcinomas, as well as help to predict the poor prognostic HPV genotypes and persistent disease following CCRT. Further large studies with longer follow up times are warranted to validate our initial findings. Level of Evidence: 1. J. Magn. Reson. Imaging 2017;45:899–907. © 2016 International Society for Magnetic Resonance in Medicine - dc.format.extent 108 bytes - dc.format.mimetype text/html - dc.relation (關聯) Journal of Magnetic Resonance Imaging, 45(3), 899-907 - dc.title (題名) 1H MR spectroscopy in cervical carcinoma using external phase array body coil at 3.0 Tesla: Prediction of poor prognostic human papillomavirus genotypes en-US dc.type (資料類型) article - dc.identifier.doi (DOI) 10.1002/jmri.25386 - dc.doi.uri (DOI) http://dx.doi.org/10.1002/jmri.25386 -