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題名 Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants
作者 Lin, Chih-Lin;Kao, Jia-Horng
林志陵
貢獻者 心理系
日期 2017
上傳時間 20-Jul-2017 15:20:28 (UTC+8)
摘要 Molecular epidemiologic studies reveal remarkable differences in the geographical distribution of hepatitis B virus (HBV) genotypes. The frequency of mutants among HBV genotypes also varies. The role of HBV genotypes/mutants in the pathogenesis of HBV infection and natural history of HBV infection has been extensively investigated. The distribution of HBV genotypes in acute hepatitis B patients reflects the predominant genotypes in a given geographic area. In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B. HBV genotypes C, D and F carry a higher lifetime risk of cirrhosis and HCC development than genotype A and B. HBV pre-S/S gene mutations were associated with immune escape of hepatitis B immunoglobulin or vaccine-induced immunity. Mutations in the pre-S, core promoter and X regions correlate with an increased risk of cirrhosis and HCC. In summary, HBV genotypes and mutants are associated with the disease progression and long-term outcome of HBV infection. They may serve as viral genetic markers for risk stratification of chronic hepatitis B patients in clinical practice. © 2017 Elsevier Ltd.
關聯 Best Practice and Research: Clinical Gastroenterology, Available online 5 May 2017
資料類型 article
DOI http://dx.doi.org/10.1016/j.bpg.2017.04.010
dc.contributor 心理系
dc.creator (作者) Lin, Chih-Lin;Kao, Jia-Horngen-US
dc.creator (作者) 林志陵zh-tw
dc.date (日期) 2017
dc.date.accessioned 20-Jul-2017 15:20:28 (UTC+8)-
dc.date.available 20-Jul-2017 15:20:28 (UTC+8)-
dc.date.issued (上傳時間) 20-Jul-2017 15:20:28 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/111259-
dc.description.abstract (摘要) Molecular epidemiologic studies reveal remarkable differences in the geographical distribution of hepatitis B virus (HBV) genotypes. The frequency of mutants among HBV genotypes also varies. The role of HBV genotypes/mutants in the pathogenesis of HBV infection and natural history of HBV infection has been extensively investigated. The distribution of HBV genotypes in acute hepatitis B patients reflects the predominant genotypes in a given geographic area. In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B. HBV genotypes C, D and F carry a higher lifetime risk of cirrhosis and HCC development than genotype A and B. HBV pre-S/S gene mutations were associated with immune escape of hepatitis B immunoglobulin or vaccine-induced immunity. Mutations in the pre-S, core promoter and X regions correlate with an increased risk of cirrhosis and HCC. In summary, HBV genotypes and mutants are associated with the disease progression and long-term outcome of HBV infection. They may serve as viral genetic markers for risk stratification of chronic hepatitis B patients in clinical practice. © 2017 Elsevier Ltd.
dc.format.extent 590362 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) Best Practice and Research: Clinical Gastroenterology, Available online 5 May 2017
dc.title (題名) Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutantsen-US
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.1016/j.bpg.2017.04.010
dc.doi.uri (DOI) http://dx.doi.org/10.1016/j.bpg.2017.04.010