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題名 Cerebral blood flow autoregulation is impaired in schizophrenia: A pilot study 作者 藍亭
Ku, Hsiao Lun
Wang, Jiunn Kae
Lee, Hsin Chien
Lane, Timothy Joseph
Liu, I. Chao
Chen, Yung Chan
Lee, Yao Tung
Lin, I. Cheng
Lin, Chia Pei
Hu, Chaur Jongh
Chi, Nai Fang貢獻者 心智、大腦與學習研究中心 關鍵詞 Cerebral autoregulation; Cerebral blood flow; Cerebrovascular diseases; Schizophrenia 日期 2017-01 上傳時間 31-Aug-2017 11:23:00 (UTC+8) 摘要 Patients with schizophrenia have a higher risk of cardiovascular diseases and higher mortality from them than does the general population; however, the underlying mechanism remains unclear. Impaired cerebral autoregulation is associated with cerebrovascular diseases and their mortality. Increased or decreased cerebral blood flow in different brain regions has been reported in patients with schizophrenia, which implies impaired cerebral autoregulation. This study investigated the cerebral autoregulation in 21 patients with schizophrenia and 23 age- and sex-matched healthy controls. None of the participants had a history of cardiovascular diseases, hypertension, or diabetes. All participants underwent 10-min blood pressure and cerebral blood flow recording through finger plethysmography and Doppler ultrasonography, respectively. Cerebral autoregulation was assessed by analyzing two autoregulation indices: the mean blood pressure and cerebral blood flow correlation coefficient (Mx), and the phase shift between the waveforms of blood pressure and cerebral blood flow determined using transfer function analysis. Compared with the controls, the patients had a significantly higher Mx (0.257 vs. 0.399, p = 0.036) and lower phase shift (44.3° vs. 38.7° in the 0.07-0.20. Hz frequency band, p = 0.019), which indicated impaired maintenance of constant cerebral blood flow and a delayed cerebrovascular autoregulatory response. Impaired cerebral autoregulation may be caused by schizophrenia and may not be an artifact of coexisting medical conditions. The mechanism underlying impaired cerebral autoregulation in schizophrenia and its probable role in the development of cerebrovascular diseases require further investigation. 關聯 Schizophrenia Research 資料類型 article DOI http://dx.doi.org/10.1016/j.schres.2017.01.015 dc.contributor 心智、大腦與學習研究中心 zh_TW dc.creator (作者) 藍亭 zh_TW dc.creator (作者) Ku, Hsiao Lun en_US dc.creator (作者) Wang, Jiunn Kae en_US dc.creator (作者) Lee, Hsin Chien en_US dc.creator (作者) Lane, Timothy Joseph en_US dc.creator (作者) Liu, I. Chao en_US dc.creator (作者) Chen, Yung Chan en_US dc.creator (作者) Lee, Yao Tung en_US dc.creator (作者) Lin, I. Cheng en_US dc.creator (作者) Lin, Chia Pei en_US dc.creator (作者) Hu, Chaur Jongh en_US dc.creator (作者) Chi, Nai Fang en_US dc.date (日期) 2017-01 dc.date.accessioned 31-Aug-2017 11:23:00 (UTC+8) - dc.date.available 31-Aug-2017 11:23:00 (UTC+8) - dc.date.issued (上傳時間) 31-Aug-2017 11:23:00 (UTC+8) - dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/112327 - dc.description.abstract (摘要) Patients with schizophrenia have a higher risk of cardiovascular diseases and higher mortality from them than does the general population; however, the underlying mechanism remains unclear. Impaired cerebral autoregulation is associated with cerebrovascular diseases and their mortality. Increased or decreased cerebral blood flow in different brain regions has been reported in patients with schizophrenia, which implies impaired cerebral autoregulation. This study investigated the cerebral autoregulation in 21 patients with schizophrenia and 23 age- and sex-matched healthy controls. None of the participants had a history of cardiovascular diseases, hypertension, or diabetes. All participants underwent 10-min blood pressure and cerebral blood flow recording through finger plethysmography and Doppler ultrasonography, respectively. Cerebral autoregulation was assessed by analyzing two autoregulation indices: the mean blood pressure and cerebral blood flow correlation coefficient (Mx), and the phase shift between the waveforms of blood pressure and cerebral blood flow determined using transfer function analysis. Compared with the controls, the patients had a significantly higher Mx (0.257 vs. 0.399, p = 0.036) and lower phase shift (44.3° vs. 38.7° in the 0.07-0.20. Hz frequency band, p = 0.019), which indicated impaired maintenance of constant cerebral blood flow and a delayed cerebrovascular autoregulatory response. Impaired cerebral autoregulation may be caused by schizophrenia and may not be an artifact of coexisting medical conditions. The mechanism underlying impaired cerebral autoregulation in schizophrenia and its probable role in the development of cerebrovascular diseases require further investigation. en_US dc.format.extent 429480 bytes - dc.format.mimetype application/pdf - dc.relation (關聯) Schizophrenia Research en_US dc.subject (關鍵詞) Cerebral autoregulation; Cerebral blood flow; Cerebrovascular diseases; Schizophrenia en_US dc.title (題名) Cerebral blood flow autoregulation is impaired in schizophrenia: A pilot study en_US dc.type (資料類型) article dc.identifier.doi (DOI) 10.1016/j.schres.2017.01.015 dc.doi.uri (DOI) http://dx.doi.org/10.1016/j.schres.2017.01.015
