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題名 Evaluating the impact of hippocampal sparing during whole brain radiotherapy on neurocognitive functions: A preliminary report of a prospective phase II study. 作者 楊啟正
Lin, Shinn‑Yn
Yang, Chi‑Cheng
Wu, Yi‑Ming
Tseng, Chen‑Kan
Wei, Kuo‑Chen
Chu, Yi‑Chuan
Hsieh, Hsiang‑Yao
Wu1, Tung‑Ho
Pai, Ping‑Ching
Hsu, Peng‑Wei貢獻者 心理系 日期 2015-09 上傳時間 6-Sep-2017 16:29:07 (UTC+8) 摘要 BACKGROUND: Whole brain radiotherapy (WBRT) is the treatment of choice for patients with brain metastases. However, neurocognitive functions (NCFs) decline due to impaired hippocampal neurogenesis might occur thereafter. It is hypothesized that conformal hippocampal avoidance during the course of WBRT (HA-WBRT) might provide meaningful NCF preservation. Our study aims to demonstrate the impact of delivering HA-WBRT on NCF changes in patients receiving WBRT. METHODS: Twenty-five patients who were referred for prophylactic cranial irradiation (PCI) or treating oligometastatic brain disease were enrolled in the study. Before the HA-WBRT course, all participants should receive baseline neurocognitive assessment, including memory, executive functions, and psychomotor speed. The primary endpoint was delayed recall, as determined by the change/decline in verbal memory [Wechsler Memory Scale - 3rd edition (WMS III)- Word List score] from the baseline assessment to 4 months after the start of HA-WBRT. 關聯 Biomedical Journal, Vol.38, No.5, pp.439-449 資料類型 article DOI https://doi.org/10.4103/2319-4170.157440 dc.contributor 心理系 zh_TW dc.creator (作者) 楊啟正 zh_TW dc.creator (作者) Lin, Shinn‑Yn en_US dc.creator (作者) Yang, Chi‑Cheng en_US dc.creator (作者) Wu, Yi‑Ming en_US dc.creator (作者) Tseng, Chen‑Kan en_US dc.creator (作者) Wei, Kuo‑Chen en_US dc.creator (作者) Chu, Yi‑Chuan en_US dc.creator (作者) Hsieh, Hsiang‑Yao en_US dc.creator (作者) Wu1, Tung‑Ho en_US dc.creator (作者) Pai, Ping‑Ching en_US dc.creator (作者) Hsu, Peng‑Wei en_US dc.date (日期) 2015-09 dc.date.accessioned 6-Sep-2017 16:29:07 (UTC+8) - dc.date.available 6-Sep-2017 16:29:07 (UTC+8) - dc.date.issued (上傳時間) 6-Sep-2017 16:29:07 (UTC+8) - dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/112529 - dc.description.abstract (摘要) BACKGROUND: Whole brain radiotherapy (WBRT) is the treatment of choice for patients with brain metastases. However, neurocognitive functions (NCFs) decline due to impaired hippocampal neurogenesis might occur thereafter. It is hypothesized that conformal hippocampal avoidance during the course of WBRT (HA-WBRT) might provide meaningful NCF preservation. Our study aims to demonstrate the impact of delivering HA-WBRT on NCF changes in patients receiving WBRT. METHODS: Twenty-five patients who were referred for prophylactic cranial irradiation (PCI) or treating oligometastatic brain disease were enrolled in the study. Before the HA-WBRT course, all participants should receive baseline neurocognitive assessment, including memory, executive functions, and psychomotor speed. The primary endpoint was delayed recall, as determined by the change/decline in verbal memory [Wechsler Memory Scale - 3rd edition (WMS III)- Word List score] from the baseline assessment to 4 months after the start of HA-WBRT. en_US dc.format.extent 2256900 bytes - dc.format.mimetype application/pdf - dc.relation (關聯) Biomedical Journal, Vol.38, No.5, pp.439-449 en_US dc.title (題名) Evaluating the impact of hippocampal sparing during whole brain radiotherapy on neurocognitive functions: A preliminary report of a prospective phase II study. en_US dc.type (資料類型) article dc.identifier.doi (DOI) 10.4103/2319-4170.157440 dc.doi.uri (DOI) https://doi.org/10.4103/2319-4170.157440
