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TitleEvaluating the impact of hippocampal sparing during whole brain radiotherapy on neurocognitive functions: A preliminary report of a prospective phase II study.
Creator楊啟正
Lin, Shinn‑Yn
Yang, Chi‑Cheng
Wu, Yi‑Ming
Tseng, Chen‑Kan
Wei, Kuo‑Chen
Chu, Yi‑Chuan
Hsieh, Hsiang‑Yao
Wu1, Tung‑Ho
Pai, Ping‑Ching
Hsu, Peng‑Wei
Contributor心理系
Date2015-09
Date Issued6-Sep-2017 16:29:07 (UTC+8)
SummaryBACKGROUND: Whole brain radiotherapy (WBRT) is the treatment of choice for patients with brain metastases. However, neurocognitive functions (NCFs) decline due to impaired hippocampal neurogenesis might occur thereafter. It is hypothesized that conformal hippocampal avoidance during the course of WBRT (HA-WBRT) might provide meaningful NCF preservation. Our study aims to demonstrate the impact of delivering HA-WBRT on NCF changes in patients receiving WBRT. METHODS: Twenty-five patients who were referred for prophylactic cranial irradiation (PCI) or treating oligometastatic brain disease were enrolled in the study. Before the HA-WBRT course, all participants should receive baseline neurocognitive assessment, including memory, executive functions, and psychomotor speed. The primary endpoint was delayed recall, as determined by the change/decline in verbal memory [Wechsler Memory Scale - 3rd edition (WMS III)- Word List score] from the baseline assessment to 4 months after the start of HA-WBRT.
RelationBiomedical Journal, Vol.38, No.5, pp.439-449
Typearticle
DOI https://doi.org/10.4103/2319-4170.157440
dc.contributor 心理系zh_TW
dc.creator (作者) 楊啟正zh_TW
dc.creator (作者) Lin, Shinn‑Ynen_US
dc.creator (作者) Yang, Chi‑Chengen_US
dc.creator (作者) Wu, Yi‑Mingen_US
dc.creator (作者) Tseng, Chen‑Kanen_US
dc.creator (作者) Wei, Kuo‑Chenen_US
dc.creator (作者) Chu, Yi‑Chuanen_US
dc.creator (作者) Hsieh, Hsiang‑Yaoen_US
dc.creator (作者) Wu1, Tung‑Hoen_US
dc.creator (作者) Pai, Ping‑Chingen_US
dc.creator (作者) Hsu, Peng‑Weien_US
dc.date (日期) 2015-09
dc.date.accessioned 6-Sep-2017 16:29:07 (UTC+8)-
dc.date.available 6-Sep-2017 16:29:07 (UTC+8)-
dc.date.issued (上傳時間) 6-Sep-2017 16:29:07 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/112529-
dc.description.abstract (摘要) BACKGROUND: Whole brain radiotherapy (WBRT) is the treatment of choice for patients with brain metastases. However, neurocognitive functions (NCFs) decline due to impaired hippocampal neurogenesis might occur thereafter. It is hypothesized that conformal hippocampal avoidance during the course of WBRT (HA-WBRT) might provide meaningful NCF preservation. Our study aims to demonstrate the impact of delivering HA-WBRT on NCF changes in patients receiving WBRT. METHODS: Twenty-five patients who were referred for prophylactic cranial irradiation (PCI) or treating oligometastatic brain disease were enrolled in the study. Before the HA-WBRT course, all participants should receive baseline neurocognitive assessment, including memory, executive functions, and psychomotor speed. The primary endpoint was delayed recall, as determined by the change/decline in verbal memory [Wechsler Memory Scale - 3rd edition (WMS III)- Word List score] from the baseline assessment to 4 months after the start of HA-WBRT.en_US
dc.format.extent 2256900 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) Biomedical Journal, Vol.38, No.5, pp.439-449en_US
dc.title (題名) Evaluating the impact of hippocampal sparing during whole brain radiotherapy on neurocognitive functions: A preliminary report of a prospective phase II study.en_US
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.4103/2319-4170.157440
dc.doi.uri (DOI) https://doi.org/10.4103/2319-4170.157440