| dc.contributor | 心理系 | zh_TW |
| dc.creator (作者) | Lin, Chih Lin | en_US |
| dc.creator (作者) | Kao, Jia Horng | en_US |
| dc.date (日期) | 2016-12 | - |
| dc.date.accessioned | 15-Sep-2017 15:19:07 (UTC+8) | - |
| dc.date.available | 15-Sep-2017 15:19:07 (UTC+8) | - |
| dc.date.issued (上傳時間) | 15-Sep-2017 15:19:07 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/113034 | - |
| dc.description.abstract (摘要) | With recent advances in molecular and genomic investigations, the impact of hepatitis B viral and host factors on the progression of chronic HBV infection has been explored. For viral factors, hepatitis B viral load is a strong predictor for liver disease progression. Hepatitis B viral kinetics appear to be important for successful anti-viral therapy. Serum HBsAg level serves as a complementary marker to viral load for the prediction of HBV-related adverse outcomes in patients with low viral load. In those with low viral load, high serum HBsAg level is associated with higher risks of cirrhosis and HCC. Hepatitis B core-related antigen (HBcrAg) induces host immune responses, and the reduction of the HBcrAg level as well as the increment of total anti-HBc level are significantly associated with favorable outcomes. HBV genotypes (genotype C/D) and mutants (basal core promoter and deletion mutation in pre-S genes) are well known viral genetic markers to predict disease progression. For host factors, serum inflammatory biomarkers have been developed to evaluate the HBV-associated hepatic necroinflammation and fibrosis. Host single nucleotide polymorphism on sodium taurocholate cotransporting polypeptide (NTCP, an HBV entry receptor) may be associated with a decreased risk for cirrhosis and HCC. In conclusion, patients with chronic hepatitis B should be evaluated with relevant viral and host markers to identify those who are at a higher risk of liver disease progression and then receive timely antiviral therapy. | en_US |
| dc.format.extent | 766560 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | Clinical and molecular hepatology, 22(4), 423-431 | en_US |
| dc.subject (關鍵詞) | biological marker; cotransporter; hepatitis B surface antigen; hepatitis B(e) antigen; organic anion transporter; sodium-bile acid cotransporter; virus DNA; blood; complication; genetics; Hepatitis B virus; Hepatitis B, Chronic; human; liver cirrhosis; risk factor; single nucleotide polymorphism; Biomarkers; DNA, Viral; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Organic Anion Transporters, Sodium-Dependent; Polymorphism, Single Nucleotide; Risk Factors; Symporters | en_US |
| dc.title (題名) | New perspectives of biomarkers for the management of chronic hepatitis B | en_US |
| dc.type (資料類型) | article | - |
| dc.identifier.doi (DOI) | 10.3350/cmh.2016.0069 | - |
| dc.doi.uri (DOI) | http://dx.doi.org/10.3350/cmh.2016.0069 | - |
