1. NCCU Academic Hub
  2. 學術產出
  3. College of Science
  4. Periodical Articles
  5. Item

學術產出-Periodical Articles

Article View/Open

Publication Export

Google ScholarTM

政大圖書館

Citation Infomation

題名 Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants
作者 林志陵
Lin, Chih-Lin
Kao, Jia-Horng
貢獻者 心理系
關鍵詞 Chronic hepatitis B; Hepatitis B virus (HBV); Genotype; HBV mutant; Cirrhosis; Hepatocellular carcinoma
日期 2017-06
上傳時間 22-Nov-2017 15:45:57 (UTC+8)
摘要 Molecular epidemiologic studies reveal remarkable differences in the geographical distribution of hepatitis B virus (HBV) genotypes. The frequency of mutants among HBV genotypes also varies. The role of HBV genotypes/mutants in the pathogenesis of HBV infection and natural history of HBV infection has been extensively investigated. The distribution of HBV genotypes in acute hepatitis B patients reflects the predominant genotypes in a given geographic area. In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B. HBV genotypes C, D and F carry a higher lifetime risk of cirrhosis and HCC development than genotype A and B. HBV pre-S/S gene mutations were associated with immune escape of hepatitis B immunoglobulin or vaccine-induced immunity. Mutations in the pre-S, core promoter and X regions correlate with an increased risk of cirrhosis and HCC. In summary, HBV genotypes and mutants are associated with the disease progression and long-term outcome of HBV infection. They may serve as viral genetic markers for risk stratification of chronic hepatitis B patients in clinical practice.
關聯 Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 3, Pages 249-255
資料類型 article
DOI https://doi.org/10.1016/j.bpg.2017.04.010
dc.contributor 心理系
dc.creator (作者) 林志陵zh_TW
dc.creator (作者) Lin, Chih-Linen_US
dc.creator (作者) Kao, Jia-Horngen_US
dc.date (日期) 2017-06
dc.date.accessioned 22-Nov-2017 15:45:57 (UTC+8)-
dc.date.available 22-Nov-2017 15:45:57 (UTC+8)-
dc.date.issued (上傳時間) 22-Nov-2017 15:45:57 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/114852-
dc.description.abstract (摘要) Molecular epidemiologic studies reveal remarkable differences in the geographical distribution of hepatitis B virus (HBV) genotypes. The frequency of mutants among HBV genotypes also varies. The role of HBV genotypes/mutants in the pathogenesis of HBV infection and natural history of HBV infection has been extensively investigated. The distribution of HBV genotypes in acute hepatitis B patients reflects the predominant genotypes in a given geographic area. In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B. HBV genotypes C, D and F carry a higher lifetime risk of cirrhosis and HCC development than genotype A and B. HBV pre-S/S gene mutations were associated with immune escape of hepatitis B immunoglobulin or vaccine-induced immunity. Mutations in the pre-S, core promoter and X regions correlate with an increased risk of cirrhosis and HCC. In summary, HBV genotypes and mutants are associated with the disease progression and long-term outcome of HBV infection. They may serve as viral genetic markers for risk stratification of chronic hepatitis B patients in clinical practice.en_US
dc.format.extent 563436 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 3, Pages 249-255en_US
dc.subject (關鍵詞) Chronic hepatitis B; Hepatitis B virus (HBV); Genotype; HBV mutant; Cirrhosis; Hepatocellular carcinomaen_US
dc.title (題名) Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutantsen_US
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.1016/j.bpg.2017.04.010
dc.doi.uri (DOI) https://doi.org/10.1016/j.bpg.2017.04.010