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題名 Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia. 作者 藍亭
Martino, Matteo
Magioncalda, Paola
Yu, Hua
Li, Xiaojing
Wang, Qiang
Meng, Yajing
Deng, Wei
Li, Yinfei
Li, Mingli
Ma, Xiaohong
Lane, Timothy
Duncan, Niall W.
Northoff, Georg
Li, Tao貢獻者 心理學系 關鍵詞 schizophrenia:substantia nigra:resting-state, fMRI:functional connectivity:slow frequency bands:neural synchronization 日期 2018-02 上傳時間 15-Jan-2018 11:39:34 (UTC+8) 摘要 Objective: The dopamine hypothesis is one of the most influential theories of the neurobiological background of schizophrenia (SCZ). However, direct evidence for abnormal dopamine-related subcortical-cortical circuitry disconnectivity is still lacking. The aim of this study was therefore to test dopamine-related substantia nigra (SN)-based striato-thalamo-cortical resting-state functional connectivity (FC) in SCZ. Method: Based on our a priori hypothesis, we analyzed a large sample resting-state functional magnetic resonance imaging (fMRI) dataset from first-episode drug-naïve SCZ patients (n = 112) and healthy controls (n = 82) using the SN as the seed region for an investigation of striato-thalamo-cortical FC. This was done in the standard band of slow frequency oscillations and then in its subfrequency bands (Slow4 and Slow5). Results: The analysis showed in SCZ: (1) reciprocal functional hypo-connectivity between SN and striatum, with differential patterns for Slow5 and Slow4; (2) functional hypo-connectivity between striatum and thalamus, as well as functional hyper-connectivity between thalamus and sensorimotor cortical areas, specifically in Slow4; (3) correlation of thalamo-sensorimotor functional hyper-connectivity with psychopathological symptoms. Conclusions: We demonstrate abnormal dopamine-related SN-based striato-thalamo-cortical FC in slow frequency oscillations in first-episode drug-naive SCZ. This suggests that altered dopaminergic function in the SN leads to abnormal neuronal synchronization (as indexed by FC) within subcortical-cortical circuitry, complementing the dopamine hypothesis in SCZ on the regional level of resting-state activity. 關聯 Schizophrenia Bulletin, Volume 44, Issue 2, Pages 419–431 資料類型 article DOI http://dx.doi.org/10.1093/schbul/sbx067 dc.contributor 心理學系 zh_TW dc.creator (作者) 藍亭 zh_TW dc.creator (作者) Martino, Matteo en_US dc.creator (作者) Magioncalda, Paola en_US dc.creator (作者) Yu, Hua en_US dc.creator (作者) Li, Xiaojing en_US dc.creator (作者) Wang, Qiang en_US dc.creator (作者) Meng, Yajing en_US dc.creator (作者) Deng, Wei en_US dc.creator (作者) Li, Yinfei en_US dc.creator (作者) Li, Mingli en_US dc.creator (作者) Ma, Xiaohong en_US dc.creator (作者) Lane, Timothy en_US dc.creator (作者) Duncan, Niall W. en_US dc.creator (作者) Northoff, Georg en_US dc.creator (作者) Li, Tao en_US dc.date (日期) 2018-02 - dc.date.accessioned 15-Jan-2018 11:39:34 (UTC+8) - dc.date.available 15-Jan-2018 11:39:34 (UTC+8) - dc.date.issued (上傳時間) 15-Jan-2018 11:39:34 (UTC+8) - dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/115565 - dc.description.abstract (摘要) Objective: The dopamine hypothesis is one of the most influential theories of the neurobiological background of schizophrenia (SCZ). However, direct evidence for abnormal dopamine-related subcortical-cortical circuitry disconnectivity is still lacking. The aim of this study was therefore to test dopamine-related substantia nigra (SN)-based striato-thalamo-cortical resting-state functional connectivity (FC) in SCZ. Method: Based on our a priori hypothesis, we analyzed a large sample resting-state functional magnetic resonance imaging (fMRI) dataset from first-episode drug-naïve SCZ patients (n = 112) and healthy controls (n = 82) using the SN as the seed region for an investigation of striato-thalamo-cortical FC. This was done in the standard band of slow frequency oscillations and then in its subfrequency bands (Slow4 and Slow5). Results: The analysis showed in SCZ: (1) reciprocal functional hypo-connectivity between SN and striatum, with differential patterns for Slow5 and Slow4; (2) functional hypo-connectivity between striatum and thalamus, as well as functional hyper-connectivity between thalamus and sensorimotor cortical areas, specifically in Slow4; (3) correlation of thalamo-sensorimotor functional hyper-connectivity with psychopathological symptoms. Conclusions: We demonstrate abnormal dopamine-related SN-based striato-thalamo-cortical FC in slow frequency oscillations in first-episode drug-naive SCZ. This suggests that altered dopaminergic function in the SN leads to abnormal neuronal synchronization (as indexed by FC) within subcortical-cortical circuitry, complementing the dopamine hypothesis in SCZ on the regional level of resting-state activity. en_US dc.format.extent 103 bytes - dc.format.mimetype text/html - dc.relation (關聯) Schizophrenia Bulletin, Volume 44, Issue 2, Pages 419–431 en_US dc.subject (關鍵詞) schizophrenia:substantia nigra:resting-state, fMRI:functional connectivity:slow frequency bands:neural synchronization en_US dc.title (題名) Abnormal Resting-State Connectivity in a Substantia Nigra-Related Striato-Thalamo-Cortical Network in a Large Sample of First-Episode Drug-Naïve Patients With Schizophrenia. en_US dc.type (資料類型) article - dc.identifier.doi (DOI) 10.1093/schbul/sbx067 - dc.doi.uri (DOI) http://dx.doi.org/10.1093/schbul/sbx067 -
