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題名 The neurophysiological basis of the discrepancy between objective and subjective sleep during the sleep onset period: an EEG-fMRI study
作者 Hsiao, Fan-Chi;Tsai, Pei-Jung;Wu, Changwei;Yang, Chien-Ming;Lane, Timothy Joseph;Lee, Hsin-Chien;Chen, Ling-Chun;Lee, We-Kang;Lu, Lu-Hsin;Wu, Yu-Zu
Hsiao, Fan-Chi
藍亭
Lane, Timothy Joseph
貢獻者 心理系
日期 2018-06
上傳時間 13-Sep-2018 17:36:46 (UTC+8)
摘要 Subjective perception of sleep is not necessarily consistent with electroencephalography (EEG) indications of sleep. The mismatch between subjective reports and objective measures is often referred to as "sleep state misperception." Previous studies evince that this mismatch is found in both patients with insomnia and in normal sleepers, but the neurophysiological mechanism remains unclear. The aim of the study is to explore the neurophysiological basis of this mechanism, from the perspective of both EEG power and functional magnetic resonance imaging (fMRI) fluctuations. Thirty-six healthy young adults participated in the study. Simultaneous EEG and fMRI recordings were conducted while the participants were trying to fall asleep in an MRI scanner at approximately 9:00 pm. They were awakened after achieving stable N1 or N2 sleep, or after 90 min without falling into stable sleep. Next they were asked to recall their conscious experiences from the moment immediately prior to awakening. Sixty-one instances of scheduled awakenings were collected: 21 of these after having achieved stable stage N2 sleep; 12, during stage N1 sleep; and, 20 during the waking state. Relative to those awakenings without subjective-objective discrepancy (n = 27), these awakenings with discrepancy (n = 14) were associated with lower θ power, as well as higher α, β, and γ power. Moreover, we found that participants who exhibited the discrepancy, compared with those who did not, evinced a higher amplitude of low-frequency fluctuation levels in the prefrontal cortex. These results lend support to the conjecture that the subjective-objective discrepancy is associated with central nervous system hyperarousal.
關聯 Sleep, Volume 41, Issue 6, 1 June 2018, zsy056
資料類型 article
DOI https://doi.org/10.1093/sleep/zsy056
dc.contributor 心理系
dc.creator (作者) Hsiao, Fan-Chi;Tsai, Pei-Jung;Wu, Changwei;Yang, Chien-Ming;Lane, Timothy Joseph;Lee, Hsin-Chien;Chen, Ling-Chun;Lee, We-Kang;Lu, Lu-Hsin;Wu, Yu-Zuen_US
dc.creator (作者) Hsiao, Fan-Chien_US
dc.creator (作者) 藍亭zh_TW
dc.creator (作者) Lane, Timothy Josephen_US
dc.date (日期) 2018-06
dc.date.accessioned 13-Sep-2018 17:36:46 (UTC+8)-
dc.date.available 13-Sep-2018 17:36:46 (UTC+8)-
dc.date.issued (上傳時間) 13-Sep-2018 17:36:46 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/120079-
dc.description.abstract (摘要) Subjective perception of sleep is not necessarily consistent with electroencephalography (EEG) indications of sleep. The mismatch between subjective reports and objective measures is often referred to as "sleep state misperception." Previous studies evince that this mismatch is found in both patients with insomnia and in normal sleepers, but the neurophysiological mechanism remains unclear. The aim of the study is to explore the neurophysiological basis of this mechanism, from the perspective of both EEG power and functional magnetic resonance imaging (fMRI) fluctuations. Thirty-six healthy young adults participated in the study. Simultaneous EEG and fMRI recordings were conducted while the participants were trying to fall asleep in an MRI scanner at approximately 9:00 pm. They were awakened after achieving stable N1 or N2 sleep, or after 90 min without falling into stable sleep. Next they were asked to recall their conscious experiences from the moment immediately prior to awakening. Sixty-one instances of scheduled awakenings were collected: 21 of these after having achieved stable stage N2 sleep; 12, during stage N1 sleep; and, 20 during the waking state. Relative to those awakenings without subjective-objective discrepancy (n = 27), these awakenings with discrepancy (n = 14) were associated with lower θ power, as well as higher α, β, and γ power. Moreover, we found that participants who exhibited the discrepancy, compared with those who did not, evinced a higher amplitude of low-frequency fluctuation levels in the prefrontal cortex. These results lend support to the conjecture that the subjective-objective discrepancy is associated with central nervous system hyperarousal.en_US
dc.format.extent 17419660 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) Sleep, Volume 41, Issue 6, 1 June 2018, zsy056
dc.title (題名) The neurophysiological basis of the discrepancy between objective and subjective sleep during the sleep onset period: an EEG-fMRI studyen_US
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.1093/sleep/zsy056
dc.doi.uri (DOI) https://doi.org/10.1093/sleep/zsy056