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題名 Effect of Pachybasin on General Toxicity and Developmental Toxicity in Vivo
作者 Lin, Yi-Ruu;Peng, Kou-Cheng;Chan, Ming-Huan;Peng, Huan-Lin;Liu, Shu-Ying
詹銘煥
Chan, Ming-Huan
貢獻者 神科所
關鍵詞 Trichoderma harzianum; developmental toxicity; general toxicity; pachybasin
日期 2017-12
上傳時間 17-Sep-2018 18:03:18 (UTC+8)
摘要 To document the safety of pachybasin, a secondary metabolite of Trichoderma harzianum, for use as a bioagricultural agent, it was subjected to general toxicological testing in mice and developmental toxicity in zebrafish. With either 5 or 20 mg kg-1 pachybasin i.p. injection, mice behavioral responses such as motor coordination, spontaneous locomotor activity, or nociceptive pain were not influenced. In long-term effect (daily injection for 14 days), the physiological, hematological, liver, and kidney functions were not altered either. Evidence for the developmental toxicity of pachybasin (10-100 μM) in 72-h exposure period was shown in zebrafish larvae, based on developmental retardation, impairment of chorion, and increase of mortality. In summary, there are no significant general toxicities presented in the pachybasin-treated adult male mice. However, the embryo-toxicity in aquatic biota should be taken into consideration during bioagricultural agent application.
關聯 J. Agric. Food Chem. 65, 48, 10489-10494
PMID: 29111710
資料類型 article
DOI https://doi.org/10.1021/acs.jafc.7b03879
dc.contributor 神科所
dc.creator (作者) Lin, Yi-Ruu;Peng, Kou-Cheng;Chan, Ming-Huan;Peng, Huan-Lin;Liu, Shu-Yingen_US
dc.creator (作者) 詹銘煥zh_TW
dc.creator (作者) Chan, Ming-Huanen_US
dc.date (日期) 2017-12
dc.date.accessioned 17-Sep-2018 18:03:18 (UTC+8)-
dc.date.available 17-Sep-2018 18:03:18 (UTC+8)-
dc.date.issued (上傳時間) 17-Sep-2018 18:03:18 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/120101-
dc.description.abstract (摘要) To document the safety of pachybasin, a secondary metabolite of Trichoderma harzianum, for use as a bioagricultural agent, it was subjected to general toxicological testing in mice and developmental toxicity in zebrafish. With either 5 or 20 mg kg-1 pachybasin i.p. injection, mice behavioral responses such as motor coordination, spontaneous locomotor activity, or nociceptive pain were not influenced. In long-term effect (daily injection for 14 days), the physiological, hematological, liver, and kidney functions were not altered either. Evidence for the developmental toxicity of pachybasin (10-100 μM) in 72-h exposure period was shown in zebrafish larvae, based on developmental retardation, impairment of chorion, and increase of mortality. In summary, there are no significant general toxicities presented in the pachybasin-treated adult male mice. However, the embryo-toxicity in aquatic biota should be taken into consideration during bioagricultural agent application.en_US
dc.format.extent 108 bytes-
dc.format.mimetype text/html-
dc.relation (關聯) J. Agric. Food Chem. 65, 48, 10489-10494
dc.relation (關聯) PMID: 29111710
dc.subject (關鍵詞) Trichoderma harzianum; developmental toxicity; general toxicity; pachybasinen_US
dc.title (題名) Effect of Pachybasin on General Toxicity and Developmental Toxicity in Vivoen_US
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.1021/acs.jafc.7b03879
dc.doi.uri (DOI) https://doi.org/10.1021/acs.jafc.7b03879