| dc.contributor | 應用物理所 | |
| dc.creator (作者) | Lin, GG;Lin, YC;Wu, RC;Yang, LY;Lu, HY;Tsai, SY;Huang, YT;Huang, YL;Lu, KY;Ng, KK;Yen, TC;Chao, A;Lai, CH;Hong, JH | |
| dc.creator (作者) | Tsai, Shang‐Yueh | |
| dc.creator (作者) | 蔡尚岳 | |
| dc.date (日期) | 2018-06 | |
| dc.date.accessioned | 26-Oct-2018 17:26:15 (UTC+8) | - |
| dc.date.available | 26-Oct-2018 17:26:15 (UTC+8) | - |
| dc.date.issued (上傳時間) | 26-Oct-2018 17:26:15 (UTC+8) | - |
| dc.identifier.uri (URI) | http://nccur.lib.nccu.edu.tw/handle/140.119/120795 | - |
| dc.description.abstract (摘要) | Background: A triage test to assist clinical decision-making on choosing primary chemoradiation for cervical carcinomas or primary surgery for endometrial carcinomas is important. Purpose or Hypothesis: To develop and validate a multiparametric prediction model based on MR imaging and spectroscopy in distinguishing adenocarcinomas of uterine cervical or endometrial origin. Study Type: Prospective diagnostic accuracy study. Population: Eighty-seven women: 25 cervical and 62 endometrial adenocarcinomas divided into training (n=43; cervical/endometrial adenocarcinomas=11/32) and validation (n=44; 14/30) datasets. Field Strength/Sequence: The 3T diffusion-weighted (DW) MR imaging and MR spectroscopy. Assessment: Morphology, volumetric DW MR imaging and spectroscopy (MDS) scoring system with total points 0-5, based on presence of the following MR features assessed independently by two radiologists: (a) epicenter at the cervix, (b) rim enhancement, (c) disrupted cervical stromal integrity, (d) mean volumetric apparent diffusion coefficient values (ADCmean) higher than 0.98 x 10-3 mm(2)/s, (e) fatty acyl delta 1.3 ppm more than 161.92mM. Histopathology as gold standard. Statistical Tests: Logistic regression and receiver operator characteristic (ROC) curves analysis. Results: For both the training and validation datasets, the MDS score achieved an accuracy of 93.0% and 84.1%, significantly higher than that of morphology (88.4% and 79.5%), ADC value (74.4% and 68.2%), and spectroscopy (81.4% and 68.2%; P<0.05 for all). The performances of the scoring were superior to the morphology in the training dataset (areas under the receiver operating characteristics curve [AUC]=0.95 vs. 0.89; P=0.046), but not in the validation dataset (AUC=0.90 vs. 0.85; P=0.289). Data Conclusion: MDS score has potentials to improve distinguishing adenocarcinomas of cervical or endometrial origin, and warrants large-scale studies for further validation. Technical Efficacy: Stage 3 | en_US |
| dc.format.extent | 662139 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.relation (關聯) | JOURNAL OF MAGNETIC RESONANCE IMAGING, 47(6), 1654-1666 | |
| dc.subject (關鍵詞) | cervical carcinoma; diffusion-weighted imaging; diagnostic accuracy; endometrial carcinoma; magnetic resonance imaging; magnetic resonance spectroscopy | |
| dc.title (題名) | Developing and validating a multivariable prediction model to improve the diagnostic accuracy in determination of cervical versus endometrial origin of uterine adenocarcinomas: A prospective MR study combining diffusion-weighted imaging and spectroscopy | en_US |
| dc.type (資料類型) | article | |
| dc.identifier.doi (DOI) | 10.1002/jmri.25899 | |
| dc.doi.uri (DOI) | http://dx.doi.org/10.1002/jmri.25899 | |
