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題名 Long-lived Indy and calorie restriction interact to extend life span
作者 Wang, Pei-Yu;Neretti, Nicola;Whitaker, Rachel;Hosier, Suzanne;Chang, Chengyi;Lu, Daniel;Rogina, Blanka;Helfand, Stephen L.
王培育
Wang, Pei-Yu
貢獻者 神科所
關鍵詞 Drosophila; insulin; physical activity; triglyceride
日期 2009-06
上傳時間 21-Nov-2018 16:22:42 (UTC+8)
摘要 Calorie restriction (CR) improves health and extends life span in a variety of species. Despite many downstream molecules and physiological systems having been identified as being regulated by CR, the mechanism by which CR extends life span remains unclear. The Drosophila gene Indy (for I`m not dead yet), involved in the transport and storage of Krebs cycle intermediates in tissues important in fly metabolism, was proposed to regulate life span via an effect on metabolism that could overlap with CR. In this study, we report that CR down regulates Indy mRNA expression, and that CR and the level of Indy expression interact to affect longevity. Optimal life span extension is seen when Indy expression is decreased between 25 and 75% of normal. Indy long-lived flies show several phenotypes that are shared by long-lived CR flies, including decreased insulin-like signaling, lipid storage, weight gain, and resistance to starvation as well as an increase in spontaneous physical activity. We conclude that Indy and CR interact to affect longevity and that a decrease in Indy may induce a CR-like status that confers life span extension.
關聯 Proceedings of the National Academy of Sciences of the United States of America, 106(23), 9262-7
PMID: 19470468
資料類型 article
DOI https://doi.org/10.1073/pnas.0904115106
dc.contributor 神科所
dc.creator (作者) Wang, Pei-Yu;Neretti, Nicola;Whitaker, Rachel;Hosier, Suzanne;Chang, Chengyi;Lu, Daniel;Rogina, Blanka;Helfand, Stephen L.
dc.creator (作者) 王培育
dc.creator (作者) Wang, Pei-Yu
dc.date (日期) 2009-06
dc.date.accessioned 21-Nov-2018 16:22:42 (UTC+8)-
dc.date.available 21-Nov-2018 16:22:42 (UTC+8)-
dc.date.issued (上傳時間) 21-Nov-2018 16:22:42 (UTC+8)-
dc.identifier.uri (URI) http://nccur.lib.nccu.edu.tw/handle/140.119/120971-
dc.description.abstract (摘要) Calorie restriction (CR) improves health and extends life span in a variety of species. Despite many downstream molecules and physiological systems having been identified as being regulated by CR, the mechanism by which CR extends life span remains unclear. The Drosophila gene Indy (for I`m not dead yet), involved in the transport and storage of Krebs cycle intermediates in tissues important in fly metabolism, was proposed to regulate life span via an effect on metabolism that could overlap with CR. In this study, we report that CR down regulates Indy mRNA expression, and that CR and the level of Indy expression interact to affect longevity. Optimal life span extension is seen when Indy expression is decreased between 25 and 75% of normal. Indy long-lived flies show several phenotypes that are shared by long-lived CR flies, including decreased insulin-like signaling, lipid storage, weight gain, and resistance to starvation as well as an increase in spontaneous physical activity. We conclude that Indy and CR interact to affect longevity and that a decrease in Indy may induce a CR-like status that confers life span extension.en_US
dc.format.extent 885978 bytes-
dc.format.mimetype application/pdf-
dc.relation (關聯) Proceedings of the National Academy of Sciences of the United States of America, 106(23), 9262-7
dc.relation (關聯) PMID: 19470468
dc.subject (關鍵詞) Drosophila; insulin; physical activity; triglycerideen_US
dc.title (題名) Long-lived Indy and calorie restriction interact to extend life spanen_US
dc.type (資料類型) article
dc.identifier.doi (DOI) 10.1073/pnas.0904115106
dc.doi.uri (DOI) https://doi.org/10.1073/pnas.0904115106